Influence of age, gender, hormonal status and smoking habits on colonic transit time

Meier, Rémy; Beglinger, Christoph; Dederding, J. P.; Meyer-Wyss, B; Fumagalli, M; Rowedder, A; Turberg, Y; Brignoli, Reto

doi:10.1111/j.1365-2982.1995.tb00231.x

Cited by 135 publications

(99 citation statements)

References 11 publications

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“…This is perhaps in contrast to what we might expect, given that DD is an age-related phenomenon, and studies of transit time in the aged show either a slower rate of passage through the colon amongst the elderly [29][30][31] , or no differences with ageing [27,[32][33][34] . In addition, Evans et al [27] observed longer transit times in females, in whom the evidence points towards a higher risk for developing DD.…”

Section: Colonic Transit Timescontrasting

confidence: 50%

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

116

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Diverticular disease (DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK. This high prevalence ranks it as one of the most common bowel disorders in western nations. The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum. Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality. In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber. In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development. We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal. We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.

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Section: Colonic Transit Timescontrasting

confidence: 50%

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Commane¹,

Arasaradnam²,

Mills³

et al. 2009

WJG

116

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“…Similar, but yet not statistically significant findings were found when comparing female and male patients. Surprisingly women showed better tagging results in our trial, although mean bowel transit times in female subjects are known to be higher than in male subjects (10,31). Thus, the argument of longer transit times does not seem to be conclusive for gender-related differences or there must be other factors influencing the effectiveness of fecal tagging.…”

Section: Discussioncontrasting

confidence: 65%

“…It is well established that average colonic transit times are increased in older persons (10,31). Thus, it should be considered to exceed the administration time of tagging solutions from 48 to 72 hours or even longer time ranges in older patients.…”

Section: Discussionmentioning

confidence: 99%

MR colonography with fecal tagging: Do individual patient characteristics influence image quality?

Kinner¹,

Kuehle²,

Langhorst³

et al. 2007

Magnetic Resonance Imaging

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Purpose:To evaluate if different patient characteristics influence performance of fecal tagging (a new MR colonography (MRC) technique to label stool to avoid bowel cleansing) and, consecutively, MR image quality. Materials and Methods:A total of 333 patients (mean age ϭ 61 years) underwent MRC with fecal tagging. Four segments of the large bowel (ascending, transverse, descending, and sigmoid colon) were assessed as for the presence of nontagged stool particles, which can impede an assessment of the colonic wall. Ratings were correlated with patients' characteristics including patient age (Ͻ55 vs. Ն55 years), body mass index (BMI) (Ͻ25 vs. Ն25), gender, and acceptance levels for fecal tagging. Statistical analysis was performed using a Mann-Whitney U-test.Results: A total of 1332 colonic segments were evaluated. Among them, 327 segments (25%) did not contain any visible stool particles. Considerably reduced image quality was found in 61 segments (5%). Best image quality was found in the sigmoid colon (mean value ϭ 1.9), while image quality of the ascending colon turned out to be worst (mean value ϭ 2.6). Fecal tagging effectiveness showed a reverse correlation with patient age. However, all other characteristics did not have a statistically significant influence on fecal tagging outcome.Conclusion: MRC in conjunction with barium-based fecal tagging led to diagnostic image quality in 95% of all colonic segments. Since tagging results were significantly decreased in patients Ն55 years, tagging protocols should to be modified in this group, i.e., by increasing the time interval of tagging administration.

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“…Anecdotal evidence suggests that females show more gastrointestinal symptoms than males, and there is evidence for such differences in irritable bowel syndrome (Chang et al, 2001). In healthy subjects, colonic intestinal transit times are slower in women than in men, with some data also influenced by body mass, hormonal, and smoking status (Meier et al, 1995;Graff et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Tachykinin NK₂Receptor and Functional Mechanisms in Human Colon: Changes with Indomethacin and in Diverticular Disease and Ulcerative Colitis

Burcher

Shang²,

Warner³

et al. 2007

J Pharmacol Exp Ther

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Neurokinin A (NKA) is an important spasmogen in human colon. We examined inflammatory disease-related changes in the tachykinin NK 2 receptor system in human sigmoid colon circular muscle, using functional, radioligand binding, and quantitative reverse transcription-polymerase chain reaction methods. In circular muscle strips, indomethacin enhanced contractile responses to NKA (p Ͻ 0.01) and to the NK 2 receptor-selective agonist [Lys 5 ,MeLeu 9 ,Nle 10 ]-NKA(4 -10) (p Ͻ 0.05) in both normal and acute diverticular disease (DD) specimens, indicating NK 2 receptor-mediated release of relaxant prostanoids. Contractile responses to both tachykinins were reduced in strips from DD (p Ͻ 0.001) and ulcerative colitis (UC) (p Ͻ 0.05) specimens. Responses to acetylcholine were no different in other strips from the same disease patients, demonstrating that the change in responsiveness to tachykinins in disease is specifically mediated by the NK 2 receptor. In membranes from UC specimens, receptor affinity for 125 I-NKA (median K D 0.91 nM, n ϭ 16) was lower (p Ͻ 0.01) than that in age-matched control specimens (K D 0.55 nM, n ϭ 40), whereas K D (0.65 nM, n ϭ 28) in DD was no different from control. No disease-related changes in receptor number (B max ) were found (mean, 2.0 -2.5 fmol/mg of wet weight tissue), suggesting that the reduced contractile responses in disease are not due to a loss of receptor number. Different mechanisms may account for the reduced contractility in DD compared with UC. A gender-related difference in receptor density was seen in controls, with B max lower in females (1.77 fmol/mg, n ϭ 15) than in males (2.60 fmol/mg, n ϭ 25, p ϭ 0.01). In contrast, no gender-related differences were seen in NK 2 receptor mRNA in control colonic muscle, indicating that the gender difference is a post-translational event.

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Influence of age, gender, hormonal status and smoking habits on colonic transit time

Cited by 135 publications

References 11 publications

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

MR colonography with fecal tagging: Do individual patient characteristics influence image quality?

Tachykinin NK₂Receptor and Functional Mechanisms in Human Colon: Changes with Indomethacin and in Diverticular Disease and Ulcerative Colitis

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Influence of age, gender, hormonal status and smoking habits on colonic transit time

Cited by 135 publications

References 11 publications

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

MR colonography with fecal tagging: Do individual patient characteristics influence image quality?

Tachykinin NK2Receptor and Functional Mechanisms in Human Colon: Changes with Indomethacin and in Diverticular Disease and Ulcerative Colitis

Contact Info

Product

Resources

About

Tachykinin NK₂Receptor and Functional Mechanisms in Human Colon: Changes with Indomethacin and in Diverticular Disease and Ulcerative Colitis