Influence of age at disease onset in the outcome of paediatric systemic lupus erythematosus

Descloux, Élodie; Durieu, I.; Cochat, Pierre; Vital-Durand, D; Ninet, J.; Fabien, Nicole; Cimaz, Rolando

doi:10.1093/rheumatology/kep067

Cited by 69 publications

(59 citation statements)

References 41 publications

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“…In other conditions that accompany SS, the rampant tooth decay that occurs as a consequence of the xerostomia is very difficult to manage but several recent studies have now shown that oral glandular secretions and sicca complaints can be improved with HCQ (Dawson et al 2005;Descloux et al 2009;Cankaya et al 2010).…”

Section: Sjögren's Syndromementioning

confidence: 99%

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

et al. 2015

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HCQ and CQ have a good reputation for being effective and relatively safe treatments in SLE, mild-moderate RA and Sjøgren's syndrome. There is need for (a) more information on their mode of action in relation to the control of these diseases, (b) scope for developing formulations that have improved pharmacokinetic and therapeutic properties and safety, and (c) further exploring their use in drug combinations not only with other disease modifying agents but also with biologics.

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Section: Sjögren's Syndromementioning

confidence: 99%

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

et al. 2015

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“…[16][17][18] Studies have reported that juvenile-onset SLE patients tend to have more aggressive presentation and course, with higher rates of organ involvement and lower life expectancy than adult-onset SLE patients. [19][20][21][22][23][24] Late-onset SLE patients tend to have more insidious onset of disease and tend to have less major organ involvement and more benign disease course. 25 However, they have a poorer prognosis than patients who developed SLE before the age of 50 years, because of the generally higher frequency of comorbid diseases and higher organ damage, due to aging and longer exposure to ''classical'' vascular risk factors.…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients

Choi

Park

Kang

et al. 2015

Lupus

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“…[10][11][12][13][14] Although cSLE may be associated with more frequent use of corticosteroids and other immunosuppressive agents than adult-onset SLE, which may in turn relate to disease damage, 3,6,15 limited data regarding therapies in early versus later onset cSLE are available. 10 The objective of this study was to examine differences between early and later onset cSLE patients followed at one academic center. The early onset cohort consisted of pre-pubertal patients diagnosed with cSLE prior to their 12th birthday, and was compared with a race and ethnicity matched cohort of cSLE patients who were pubertal at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Early versus later onset childhood-onset systemic lupus erythematosus: Clinical features, treatment and outcome

Hui-Yuen

Imundo

Avitabile

et al. 2011

Lupus

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The objective of the study was to compare clinical features, treatment and disease outcome in patients with early versus later onset of childhood-onset systemic lupus erythematosus (cSLE). A retrospective matched cohort study of cSLE patients diagnosed between 1988 and 2008 and followed for a minimum of one year was conducted. Thirty-four pre-pubertal cSLE patients with disease onset prior to their 12th birthday were matched by ethnicity and year of diagnosis to 34 pubertal cSLE patients. The most common criteria at diagnosis in both groups were malar rash, arthritis, hematologic manifestations, and renal disease. After a mean follow-up of more than six years, a similar proportion of patients in the two groups were still prescribed corticosteroids (47% and 41%); patients in the early onset group required a significantly higher daily dose (0.6 mg/kg prednisone-equivalent versus 0.2 mg/kg, p < 0.05). There were no significant differences in organ involvement, disease activity and disease damage between the two groups, and severe complications occurred at similar rates. There were a greater number of admissions to the pediatric intensive care unit (PICU) in the early onset group (18 versus 5, p = 0.01), with time-to-event analysis demonstrating a significantly shorter disease duration from diagnosis to first PICU admission in the early onset group (p < 0.001). While a similar proportion of patients in the early and later onset groups required treatment with cyclophosphamide, patients in the early onset group received treatment earlier in their disease course (mean 13.7 versus 19.9 months, p < 0.001). Early onset cSLE leads to earlier and more frequent PICU admission, earlier use of cyclophosphamide, and higher corticosteroid dose at long-term follow-up.

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Influence of age at disease onset in the outcome of paediatric systemic lupus erythematosus

Cited by 69 publications

References 41 publications

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients

Early versus later onset childhood-onset systemic lupus erythematosus: Clinical features, treatment and outcome

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