Influence of age and regional differences on skin elasticity as measured by the Cutometer<sup>®</sup>

Ryu, Hyo Sub; Joo, Young Chang; Kim, Sun Ok; Park, Kyoung Chan; Youn, Sang Woong

doi:10.1111/j.1600-0846.2008.00302.x

Cited by 239 publications

(249 citation statements)

References 14 publications

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“…To analyse skin elasticity, the R5 value (Ur/Ue, immediate recovery/elastic deformation) was recorded. This parameter has proven to be most suitable in detecting age-related skin alterations [19,20]. The measurement of each test area was repeated 3 times.…”

Section: Methodsmentioning

confidence: 99%

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Proksch¹,

Segger²,

Degwert³

et al. 2013

Skin Pharmacol Physiol

185

147

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Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging. In this double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application (t0) and after 4 (t1) and 8 weeks (t2) of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH (t3, 4-week regression phase). At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance. No side effects were noted throughout the study.

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Section: Methodsmentioning

confidence: 99%

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Proksch¹,

Segger²,

Degwert³

et al. 2013

Skin Pharmacol Physiol

185

147

View full text Add to dashboard Cite

show abstract

“…9,11 Cutometer has been used as a tool in the research of normal skin and skin diseases that affect skin mechanics, such as psoriasis, scleroderma and diabetes mellitus. [12][13][14][15] However, to our knowledge, no study has systematically examined skin affected by SCI with the intention to define the precise biomechanical features and to elucidate which nervous systems are directly associated with skin alterations.…”

Section: Introductionmentioning

confidence: 99%

Sympathetic influence on biomechanical skin properties after spinal cord injury

et al. 2010

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Study design: Case-control study. Objectives: To investigate changes of biomechanical skin properties and their relationship with paralysis following spinal cord injury (SCI). Setting: South Korea. Methods: A total of 48 male subjects with chronic SCI and 48 age-matched healthy controls were enrolled into this study. The C4 shoulder group and L2 thigh group were prescribed by two measured anatomical regions that represented the C4 and L2 American Spinal Injury Association sensory dermatomes. Each anatomical group was comprised of one control subgroup and three SCI subgroups determined by sympathetic paralysis at the measured region and somatic completeness. The following biomechanical skin properties were compared between the subgroups in each anatomical group by using Cutometer, a non-invasive suction device: distensibility (Uf), elasticity (Ua/Uf and Ur/Uf) and viscoelasticity (Uv/Ue and H). The impact of sympathetic and somatic sensory paralysis, somatic completeness, age, smoking, body mass index and duration of injury on the indices of skin properties were analyzed. Results: In each anatomical group, sympathetic paralyzed subgroups regardless of somatic sensory completeness showed lower value of skin distensibility (Uf), and higher values of elasticity (Ua/Uf and Ur/Uf) and viscoelasticity (Uv/Ue and H), compared with other subgroups. Age and duration of injury had significant impact on biomechanical skin properties. Conclusion: The non-invasive suction method is useful for quantitative evaluation of skin affected by SCI. In chronic SCI patients, biomechanical skin properties are significantly altered in the skin with sympathetic paralysis rather than somatic sensory paralysis.

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“…relaxed for 1.0 s. The following elastic parameters were used for the evaluation of elasticity: gross elasticity (R2), net elasticity (R5), and the ratio of elastic recovery to the total deformation (R7). These parameters are known to be important indicators of skin elastic changes with aging (24). The forearm skin colors were measured using a CM-2600d to determine a* (red), b* (yellow), and L* (brightness) color values.…”

Section: Clinical Trialmentioning

confidence: 99%

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

Yui

Fujiwara

Harada

et al. 2017

J Nutr Sci Vitaminol

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Summary Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine. Rosmarinic acid (RA), a typical polyphenol in Lamiaceae plants, was identified as a major active component in LB extract (LBE). Furthermore, LBE or RA dose-dependently suppressed glycation-associated reactions such as increased fluorescence, yellowing of collagen fiber sheets, and degeneration of the fibrous structure of elastin fiber sheets. An open-label, parallel-group comparative trial was conducted in 28 healthy Japanese subjects aged 31-65 y who consumed LB tea (LB group) or barley tea (Control group) for 6 wk. The LB group showed significant reductions in brachial-ankle pulse wave velocity, reflecting arterial stiffness, and b* (yellow) color values in forearm skin compared with the Control group. A gender-stratified analysis revealed that cheek skin elasticity was significantly improved in the LB group compared with the Control group only in female subjects. It is concluded that the hot water extract of LB leaf has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults. Key Words lemon balm, glycation, pentosidine, arterial stiffness, skin elasticity Glycation, the non-enzymatic glycosylation of proteins, is known to be involved in the onset of various diseases and conditions of aging. The substances generated by this reaction are known as advanced glycation endproducts (AGEs). Since the tissue contents of AGEs in diabetic patients (1, 2) and diabetic animals (3) are known to be much higher than in their healthy counterparts, AGEs are considered to be involved in the progression of complications of diabetes such as diabetic nephropathy (4) and cataracts (5). Involvement of the accumulation of AGEs in cardiovascular diseases (6, 7) and Alzheimer's disease (8) has also been reported.However, the stiffness of tissues such as arteries and skin is known to increase with age (9, 10) and is especially high in patients with diabetes compared to healthy subjects (9, 11). Pentosidine, one of the crosslinking AGEs, has a structure in which the lysine and arginine residues of tissue protein are cross-linked by a pentose such as ribose (12). It has been reported that pentosidine content increases with age (2, 9, 12) and positively correlates with the degree of tissue stiffness (7,13,14). One of the causes of the deterioration of tissue elasticity in elderly or diabetic patients is considered to be the accumulation of crosslinking AGEs su...

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Influence of age and regional differences on skin elasticity as measured by the Cutometer^®

Abstract: The viscoelastic properties were significantly influenced by aging. Also, significant regional variations in the viscoelastic properties were observed. Skin elasticity measurement is useful for the quantitative evaluation of age-related changes.

Cited by 239 publications

References 14 publications

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Sympathetic influence on biomechanical skin properties after spinal cord injury

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

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Influence of age and regional differences on skin elasticity as measured by the Cutometer®

Abstract: The viscoelastic properties were significantly influenced by aging. Also, significant regional variations in the viscoelastic properties were observed. Skin elasticity measurement is useful for the quantitative evaluation of age-related changes.

Cited by 239 publications

References 14 publications

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Sympathetic influence on biomechanical skin properties after spinal cord injury

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

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Product

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Influence of age and regional differences on skin elasticity as measured by the Cutometer^®