Influence of age and hematocrit on the coagulation of blood

Ujiié, Hiroshi; Kawasaki, Mineo; Suzuki, Yoshiaki; Kaibara, Makoto

doi:10.1007/s12573-010-0015-y

Cited by 8 publications

(3 citation statements)

References 23 publications

(28 reference statements)

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“…Recent studies have revealed that blood coagulation is HCT dependent in which patients with an abnormally lower HCT might interfere with the capability of blood coagulation for bleeding, and that with an abnormally higher HCT of the blood is more likely to be associated with the increasing risk with the formation of thrombosis or embolism. 36 Our results demonstrate that it is possible to recognize abnormality in the coagulation rate by OCT detection.…”

Section: Resultsmentioning

confidence: 53%

Optical coherence tomography to investigate optical properties of blood during coagulation

Lin

2011

J. Biomed. Opt.

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Abstract. This study investigates the optical properties of human blood during the coagulation process under statics using optical coherence tomography (OCT). OCT signal slope (OCTSS) and 1/e light penetration depth (d 1/e ) were obtained from the profiles of reflectance versus depth. Results showed that both OCTSS and d 1/e were able to sensitively differentiate various stages of blood properties during coagulating. After 1 h clotting, OCTSS decreased by 47.0%, 15.0%, 13.7%, and 8.5% and d 1/e increased by 34.7%, 29.4%, 24.3%, and 22.9% for the blood samples at HCT of 25%, 35%, 45%, and 55%, respectively. The slope of d 1/e versus time (S r , ×10 − 4 mm/s), associated with clot formation rate decreased from 6.0 ± 0.3, 3.7 ± 0.5 to 2.3 ± 0.4 with the increasing of HCT from 35%, 45%, to 55%. The clotting time (t c ) from the d 1/e evolution curves was estimated to be 1969 ± 92 s, 375 ± 12 s, 455 ± 11 s, and 865 ± 47 s for the blood of 25%, 35%, 45%, and 55%. This study demonstrates that the parameters (t c and S r ) from the variations in d 1/e had better sensitivity and smaller standard deviation. Furthermore, blood hematocrit affecting backscattering properties of blood during coagulation was capable of being discerned by OCT parameters. It is concluded that OCT is a potential technique to quantify and follow the liquid-gel transition of blood during clotting. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Resultsmentioning

confidence: 53%

Optical coherence tomography to investigate optical properties of blood during coagulation

Lin

2011

J. Biomed. Opt.

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“…The Ti value for the type II group was somewhat smaller than that for the type I group. It has been reported that coagulation of blood occurs faster in the elderly than in young adults, although Ti values are dependent on individuals [7,14], and hematocrit [15]. It is known that an increase in the fibrinogen concentration often leads to enhanced erythrocyte sedimentation [16], and blood coagulation is also enhanced by an increase in fibrinogen concentration [17].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous measurement of blood coagulation and erythrocyte sedimentation by means of a rheological technique

et al. 2010

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With a damped-oscillation rheometer, changes in the rheological properties, i.e., logarithmic damping factor (LDF) and period, as obtained from a damped-oscillation curve, were monitored during the coagulation of blood. In our earlier studies, the time of onset of coagulation (Ti) of the blood sample was only determined from the change in LDF. When coagulation of the blood and sedimentation of erythrocytes occurred together, the Ti value could not be determined from the change in LDF. In this paper, a method for determining the Ti value from the change in the period of the damped-oscillation curve was investigated. It was found that the period increased and leveled off as blood coagulation progressed, and the Ti value was determined from the middle point between the minimum and maximum values of the period. In addition, it was suggested that the level of erythrocyte sedimentation could be estimated from the initial decrease in LDF. In blood obtained from diabetic patients, a good correlation between the initial decrease in the LDF and the concentration of fibrinogen was observed. Our study demonstrates that when erythrocyte sedimentation and blood coagulation occur simultaneously, this rheological technique makes it possible to measure the Ti value and erythrocyte sedimentation.

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“…Dehydration may also be linked to hematocrit increase and to an increased risk of thrombogenesis [8].…”

Section: Physiology Including Response To Tissue Damagementioning

confidence: 99%

Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation

Ramadori

2021

IJMS

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Hypercoagulation is one of the major risk factors for ICU treatment, mechanical ventilation, and death in critically ill patients infected with SARS-CoV-2. At the same time, hypoalbuminemia is one risk factor in such patients, independent of age and comorbidities. Especially in patients with severe SARS-CoV-2-infection, albumin infusion may be essential to improve hemodynamics and to reduce the plasma level of the main marker of thromboembolism, namely, the D-dimer plasma level, as suggested by a recent report. Albumin is responsible for 80% of the oncotic pressure in the vessels. This is necessary to keep enough water within the systemic circulatory system and for the maintenance of sufficient blood pressure, as well as for sufficient blood supply for vital organs like the brain, lungs, heart, and kidney. The liver reacts to a decrease in oncotic pressure with an increase in albumin synthesis. This is normally possible through the use of amino acids from the proteins introduced with the nutrients reaching the portal blood. If these are not sufficiently provided with the diet, amino acids are delivered to the liver from muscular proteins by systemic circulation. The liver is also the source of coagulation proteins, such as fibrinogen, fibronectin, and most of the v WF VIII, which are physiological components of the extracellular matrix of the vessel wall. While albumin is the main negative acute-phase protein, fibrinogen, fibronectin, and v WF VIII are positive acute-phase proteins. Acute illnesses cause the activation of defense mechanisms (acute-phase reaction) that may lead to an increase of fibrinolysis and an increase of plasma level of fibrinogen breakdown products, mainly fibrin and D-dimer. The measurement of the plasma level of the D-dimer has been used as a marker for venous thromboembolism, where a fourfold increase of the D-dimer plasma level was used as a negative prognostic marker in critically ill SARS-CoV-2 hospitalized patients. Increased fibrinolysis can take place in ischemic peripheral sites, where the mentioned coagulation proteins can become part of the provisional clot (e.g., in the lungs). Although critically ill SARS-CoV-2-infected patients are considered septic shock patients, albumin infusions have not been considered for hemodynamic resuscitation and as anticoagulants. The role of coagulation factors as provisional components of the extracellular matrix in case of generalized peripheral ischemia due to hypoalbuminemia and hypovolemia is discussed in this review.

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Influence of age and hematocrit on the coagulation of blood

Cited by 8 publications

References 23 publications

Optical coherence tomography to investigate optical properties of blood during coagulation

Optical coherence tomography to investigate optical properties of blood during coagulation

Simultaneous measurement of blood coagulation and erythrocyte sedimentation by means of a rheological technique

Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation

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