Influence of age and gender on the 28-joint Disease Activity Score (DAS28) in rheumatoid arthritis

Abstract

A high DAS28 was found to perform equally in all age groups, in men and women, despite the elevating effect of age on ESR. In elderly men with low disease activity, remission rate could be underestimated by an elevated ESR.

Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis

“…Radovits et al showed that age had no influence on the DAS28-ESR in RA patients with moderate-to-high disease activity. They also suggested that EULAR response categories were not altered in elderly patients [25]. We used the DAS28 score because it is the most widely used in clinical practice even though another method of evaluation of the response, excluding ESR or CRP (CDAI) would be more relevant with TCZ [26].…”

La polyarthrite rhumatoïde du sujet âgé

“…Le traitement est rendu plus difficile par la présence de pathologies associées (comorbidité) et par l'augmentation des effets secondaires médi-camenteux. La pertinence du Disease activity score (DAS), pour suivre l'évolution de la PR du sujet âgé a été soulevée, en raison de l'augmentation de la vitesse de sédimentation avec l'âge [12]. À partir d'une cohorte de 553 patients suivis pendant 20 ans, Radovits et al ont étudié l'influence de l'âge, du sexe et la part de la vitesse de sédimentation dans les variations du DAS chez les sujets de moins de 45 ans, de 45 à 65 ans et de plus de 65 ans.…”

Influence of age and sex on functional outcome over time in a cohort of patients with recent‐onset inflammatory polyarthritis: Results from the Norfolk arthritis register

“…However, of growing concern in an aging population are findings that patients with late-onset RA have a worse prognosis than early-onset patients, in terms of DAS28 score, HAQ score, and degree of radiographic damage (3,5). On the other hand, there has also been a number of reports that early-onset and lateonset RA patients have a comparable prognosis in terms of radiographic damage, inflammation (as measured by C-reactive protein [CRP] level), disability (as measured by HAQ score), and disease activity (as measured by DAS28 score) (2,17,18).…”