Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head

Li, Guangyi; Zheng, Qiujian; Landao-Bassonga, Euphemie; Cheng, Tak Sum; Pavlos, Nathan J.; Ma, Yuanfang; Zhang, Changqing; Zheng, Ming

doi:10.1016/j.bone.2015.04.019

Cited by 31 publications

(25 citation statements)

References 60 publications

(73 reference statements)

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“…Then the sections were polished to 20 to 30 μm with the abrasive paper and conducted with Goldner trichrome staining to distinguish between the mineralized bone and osteoid bone . The subchondral bone remodeling parameters were measured by Bioquant Osteo Imaging Toolkit Plug‐in (Bioquant, Nashville, TN, USA): the osteoid thickness (O.Th, μm), osteoid surface percentage (OS/BS, %), eroded surface percentage (ES/BS, %), and ratio of osteoid surface to eroded surface (OS/ES) . Five sequential sections in each specimen were stained, and five areas in each section were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis

Chu

Liu

et al. 2019

Journal of Bone and Mineral Research

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Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP changes on OA progression in patients with osteoporotic OA (OP‐OA) has not been reported, especially the potential association between subchondral bone and articular cartilage. Thus we investigated the alterations in the microstructure, biomechanical properties, and remodeling of subchondral bone as well as their association with cartilage damage in the hip joint of patients with OP‐OA. Thirty‐nine femoral head specimens were obtained from patients who underwent total hip arthroplasty (OA group, n = 19; OP‐OA group, n = 20), and healthy specimens from cadaver donors were used (control group, n = 10). The microstructure and biomechanical properties of subchondral bone were evaluated by micro–computed tomography and micro–finite‐element analysis. Histology, histomorphometric measurements, and immunohistochemistry were used to assess subchondral bone remodeling and cartilage damage. Linear regression analysis was performed to elucidate the relationship between subchondral bone and articular cartilage. In the subchondral bone of the OP‐OA group, compared with that of the OA group, aberrant bone remodeling leads to an inferior microstructure and worsening biomechanical properties, potentially affecting transmission of loading stress from the cartilage to the subchondral bone, and then resulting in accelerated OA progression in patients with OP‐OA. The results indicate that changes in subchondral bone could affect OA development and the improvement in subchondral bone with bone‐metabolism agents may help mitigate OA progression when OP and OA coexist in the same patients. © 2019 American Society for Bone and Mineral Research.

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Section: Methodsmentioning

confidence: 99%

Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis

Chu

Liu

et al. 2019

Journal of Bone and Mineral Research

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“…The sites were chosen specifically to represent regions subjected to different amounts of in vivo loading. Li, et al 25 explored subchondral bone changes with respect to the depth of bone relative to the loading surface, showing a distinct difference in micro architecture and bone remodelling between the deeper and more superior regions of subchondral bone. However, both studies were restricted to excised cores of trabecular bone at discrete locations.…”

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confidence: 99%

A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

Ryan

Barnett

Rochester

et al. 2020

Sci Rep

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Osteoarthritis affects the morphological properties of the femoral head. The goal of this study was to develop a method to elucidate whether these changes are localised to discrete regions, or if the reported trends in microstructural changes may be identified throughout the subchondral bone of the human femoral head. Whole femoral heads extracted from osteoarthritic (n = 5) and healthy controls (n = 5) underwent microCT imaging 39 μm voxel size. the subchondral bone plate was virtually isolated to evaluate the plate thickness and plate porosity. The trabecular bone region was divided into 37 volumes of interest spatially distributed in the femoral head, and bone morphometric properties were determined in each region. the study showed how the developed approach can be used to study the heterogeneous properties of the human femoral head affected by a disease such as osteoarthritis. As example, in the superior femoral head osteoarthritic specimens exhibited a more heterogeneous micro-architecture, with trends towards thicker cortical bone plate, higher trabecular connectivity density, higher trabecular bone density and thicker structures, something that could only be observed with the newly developed approach. Bone cysts were mostly confined to the postero-lateral quadrants extending from the subchondral region into the mid trabecular region. Nevertheless, in order to generalise these findings, a larger sample size should be analysed in the future. This novel method allowed a comprehensive evaluation of the heterogeneous micro-architectural properties of the human femoral head, highlighting effects of OA in the superior subchondral cortical and trabecular bone. Further investigations on different stages of OA would be needed to identify early changes in the bone.

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“…23 After fixation, all tissue blocks were examined using a micro-CT scanner (Skyscan 1174, Bruker, Kontich, Belgium) according to previous publication. 24 25 The following parameters were calculated: bone volume fraction (BV/TV, %), trabecular thickness (Tb.Th, μm), trabecular separation (Tb.Sp, μm), trabecular number (Tb.N, 1/mm), structure model index (SMI), degree of anisotropy (DA) and connectively density (Conn.Dn, 1/mm 3 ). Bone mineralised density (BMD, mg/cm 3 ) of subchondral bone (SCB) was calibrated by using the attenuation coefficient of two defined BMD phantoms of 0.25 and 0.75 g/cm 3 .…”

Section: Micro-ctmentioning

confidence: 99%

Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis

et al. 2020

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ObjectivesObesity is a well-recognised risk factor for osteoarthritis (OA). Our aim is to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity is the major causal antecedent of early joint replacement in patients with OA.MethodsWe analysed the correlation between BMI and the age at which patients undergo total knee replacement (TKR) in 41 023 patients from the Australian Orthopaedic Association National Joint Replacement Registry. We then investigated the effect of BMI on pathological changes of the tibia plateau of knee joint in a representative subset of the registry.Results57.58% of patients in Australia who had TKR were obese. Patients with overweight, obese class I & II or obese class III received a TKR 1.89, 4.48 and 8.08 years earlier than patients with normal weight, respectively. Microscopic examination revealed that horizontal fissuring at the osteochondral interface was the major pathological feature of obesity-related OA. The frequency of horizontal fissure was strongly associated with increased BMI in the predominant compartment. An increase in one unit of BMI (1 kg/m2) increased the odds of horizontal fissures by 14.7%. 84.4% of the horizontal fissures were attributable to obesity. Reduced cartilage degradation and alteration of subchondral bone microstructure were also associated with increased BMI.ConclusionsThe key pathological feature in OA patients with obesity is horizontal fissuring at the osteochondral unit interface. Obesity is strongly associated with a younger age of first TKR, which may be a result of horizontal fissures.

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Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head

Cited by 31 publications

References 60 publications

Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis

Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis

A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis

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