Influence of Aerosol Mask Design on Fugitive Aerosol Concentrations During Nebulization

Chiang, Chen-En; Li, Hsin-Hsien; Rowley, Daniel D; Fang, Tien-Pei; Lin, Hui-Ling

doi:10.4187/respcare.10578

Cited by 2 publications

(1 citation statement)

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“…In the single head-to-head radio scintigraphy study reported in humans, Dugernier et al [ 16 ] reported superior delivery with an in-line VMN over an in-line JN, 3.6% versus 1%. Furthermore, JN themselves are contraindicated against by the largest HFNO therapy system manufacturers for reasons including interference with both oxygen FiO2 and gas flow rates, and require the circuit to broken for JN refilling, which may lead to lung derecruitment, a reduction in the applied PEEP and release of fugitive medical and bioaerosols [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

In-Line Aerosol Therapy via Nasal Cannula during Adult and Paediatric Normal, Obstructive, and Restrictive Breathing

Mac Giolla Eain,

MacLoughlin

2023

Pharmaceutics

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High-flow nasal oxygen therapy is being increasingly adopted in intensive and home care settings. The concurrent delivery of aerosolised therapeutics allows for the targeted treatment of respiratory illnesses. This study examined in-line aerosol therapy via a nasal cannula to simulated adult and paediatric models with healthy, obstructive and restrictive lung types. The Aerogen Solo vibrating mesh nebuliser was used in combination with the InspiredTM O2FLO high-flow therapy system. Representative adult and paediatric head models were connected to a breathing simulator, which replicated several different states of lung health. The aerosol delivery was quantified at the tracheal level using UV-spectrophotometry. Testing was performed at a range of supplemental gas flow rates applicable to both models. Positive end-expiratory pressure was measured pre-, during and post-nebulisation. The increases in supplemental gas flow rates resulted in a decrease in aerosol delivery, irrespective of lung health. Large tidal volumes and extended inspiratory phases were associated with the greatest aerosol delivery. Gas flow to inspiratory flow ratios of 0.29–0.5 were found to be optimum for aerosol delivery. To enhance aerosol delivery to patients receiving high-flow nasal oxygen therapy, respiratory therapists should keep supplemental gas-flow rates below the inspiratory flow of the patient.

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