Influence of adsorption on structure formation in eutectic systems

Podolinsky, V.V.; Taran, Yu. N.

doi:10.1016/0022-0248(81)90173-1

Cited by 19 publications

(10 citation statements)

References 2 publications

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“…According to the Tamman's rule, the lower melting component (PEG) is the major phase in the eutectic mixture and PEG-drug eutectic crystallization will have a well defined microstructure with a reduction in drug particle size. 14,28) The complete miscibility of ibuprofen and PEG in the liquid phase indicates polymer-drug interaction at elevated temperatures, and the recognition that there would be negligible polymer-drug interaction in the solid state (due to lattice mismatch) imposes a significant constraint on drug loading at the solid solution limit. 14) As the melt of any composition other than that corresponding to the eutectic is cooled, one component will progressively solidify, thereby rendering the remaining liquor richer in the other component until the eutectic composition is reached, and at that point, the remaining liquid will solidify as a fine dispersion.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems

et al. 2008

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To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C max , and a significant decrease in T max over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.

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Section: Resultsmentioning

confidence: 99%

Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems

et al. 2008

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“…As the melt of any composition other than that corresponding to the eutectic is cooled, one component will progressively solidify, thereby rendering the remaining liquor richer in the other component until the eutectic composition is reached, and at that point, the remaining liquid will solidify as a fine dispersion. According to the Tamman's rule, poloxamer (the lower melting component -the major phase) -ibuprofen eutectic crystallization have well defined microstructure with a reduction in drug particle size (Podolinsky and Taran 1981;Passerini et al, 2002). The DSCs of 1:1 w/w dispersions and physical mixtures (PMs) exhibited two endothermic events.…”

Section: Differential Scanning Calorimetry and Fourier Transform Infmentioning

confidence: 99%

Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407

Newa

Bhandari

et al. 2008

Arch. Pharm. Res.

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To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C(max) of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.

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“…According to Jackson and Hunt2 the entropy of melting (Δ S f ) of the pure components determines if the two components of a eutectic mixture crystallize simultaneously, and thus dictates the solid‐state microstructure of the eutectic mixture. Finally, Podolinsky and Taran3 reported that when the two components of a eutectic mixture crystallize simultaneously, size reduction of the minor component occurs. Therefore, through the choice of an appropriate carrier, it is possible to take advantage of this microstructure to improve the of dissolution rate of poorly soluble compounds.…”

Section: Introductionmentioning

confidence: 99%