Influence of Adiponectin and Resistin Gene Polymorphisms on Quantitative Traits Related to Metabolic Syndrome Among Malay, Chinese, and Indian Men in Malaysia

Lau, Cia-Hin; Muniandy, Sekaran

doi:10.1007/s10528-012-9552-y

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Several studies with conflicting results have examined the relationship of resistin gene ( RETN ) variation with MS and circulating resistin levels ( 3 , 7 – 8 ). In the present study, RETN −420C>G (rs1862513) and +299G>A (rs3745367) polymorphisms were chosen as tags because the G allele of single nucleotide polymorphism (SNP) −420C>G and the A allele of SNP +299G>A, in haplotype and separately, were related with increased risk of impaired beta-cell function and insulin sensitivity ( 9 ); SNP −420C>G effect on resistin expression may be due to its effect on transcription factor binding to RETN promoter ( 10 ). Thus, the present study has been interested in investigating the knowledge on the association between RETN polymorphisms and resistin levels that may represent one of the several etiological mechanisms connecting RETN and MS.…”

Section: Introductionmentioning

confidence: 99%

Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais / Asocijacija Nivoa Rezistina Sa Polimorfizmom Gena Za Rezistin I Metaboličkim Sindromom Kod Tajlanđana

Suriyaprom¹,

Tungtrongchitr²,

Namjuntra³

2015

Journal of Medical Biochemistry

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SummaryBackgroundMetabolic syndrome (MS) is a clinical constellation comprising risk factors associated with developing cardiovascular disease and type 2 diabetes. Resistin has been suggested as a linkage between obesity, inflammation and type 2 diabetes. This study aimed to investigate resistin concentrations and hematological-biochemical parameters in MS subjects and controls, and to determine whether two resistin gene (RETN) polymorphisms (−420C>G & +299G>A) are linked to resistin levels and MS among Thais.MethodsThis case-control study was performed with 322 Thai volunteers: 160 MS subjects and 162 controls. Anthropometric parameters and hematological-biochemical variables were determined. The RETN −420C>G (rs1862513) and +299G>A (rs3745367) polymorphisms were genotyped by PCR-RFLP technique.ResultsThe resistin levels of the MS group were significantly higher than those of the control group. Resistin levels were positively correlated with anthropometric parameters and WBC count in the MS group. According to RETN −420C>G polymorphism, MS subjects with the G allele (CG/GG) (3.9 μg/L) had significantly higher resistin concentrations than in subjects with the CC genotype (2.4 μg/L); with regard to RETN +299G>A polymorphism, carriers with the A allele (GA/AA) (3.8 μg/L) had significantly higher resistin levels than subjects with the GG genotype (2.7 μg/L), after adjusting for potential covariates. However, the RETN −420C>G and +299G>A polymorphisms were not found to be associated with MS, hematological-biochemical parameters and anthropometric variables.ConclusionsThese findings suggest resistin levels are linked with MS and the RETN −420C>G and +299G>A polymorphisms have impacted the circulating resistin concentrations. However, these two RETN polymorphisms probably do not influence susceptibility to MS among Thais.

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Section: Introductionmentioning

confidence: 99%

Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais / Asocijacija Nivoa Rezistina Sa Polimorfizmom Gena Za Rezistin I Metaboličkim Sindromom Kod Tajlanđana

Suriyaprom¹,

Tungtrongchitr²,

Namjuntra³

2015

Journal of Medical Biochemistry

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Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects

et al. 2019

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Biomarkers of Metabolic Syndrome: Biochemical Background and Clinical Significance

Robberecht

Hermans

2016

Metabolic Syndrome and Related Disorders

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Biomarkers of the metabolic syndrome are divided into four subgroups. Although dividing them in groups has some limitations, it can be used to draw some conclusions. In a first part, the dyslipidemias and markers of oxidative stress are discussed, while inflammatory markers and cardiometabolic biomarkers are reviewed in a second part. For most of them, the biochemical background and clinical significance are discussed, although here also a well-cut separation cannot always be made. Altered levels cannot always be claimed as the cause, risk, or consequence of the syndrome. Several factors are interrelated to each other and act in a concerted, antagonistic, synergistic, or modulating way. Most important conclusions are summarized at the end of every reviewed subgroup. Genetic biomarkers or influences of various food components on concentration levels are not included in this review article.

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Influence of Adiponectin and Resistin Gene Polymorphisms on Quantitative Traits Related to Metabolic Syndrome Among Malay, Chinese, and Indian Men in Malaysia

Cited by 4 publications

References 24 publications

Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais / Asocijacija Nivoa Rezistina Sa Polimorfizmom Gena Za Rezistin I Metaboličkim Sindromom Kod Tajlanđana

Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais / Asocijacija Nivoa Rezistina Sa Polimorfizmom Gena Za Rezistin I Metaboličkim Sindromom Kod Tajlanđana

Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects

Biomarkers of Metabolic Syndrome: Biochemical Background and Clinical Significance

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