Influence of Adipokines and Ghrelin on Bone Mineral Density and Fracture Risk: A Systematic Review and Meta-Analysis

Biver, Emmanuel; Salliot, Carine; Combescure, Christophe; Gossec, Laure; Hardouin, Pierre; Legroux-Gérot, Isabelle; Cortet, Bernard

doi:10.1210/jc.2011-0047

Cited by 210 publications

(189 citation statements)

References 95 publications

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“…Evidence from a systemic review and meta-analysis showed that adiponectin is the most relevant adipokine negatively associated to BMD, independent of gender, menopausal status, and fat mass parameters [48]. Therefore, human studies suggest adiponectin as a negative factor for BMD.…”

Section: Discussionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β =−0.11, p= 0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

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Section: Discussionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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show abstract

“…Indeed, general obesity and body weight are the strongest protectors against bone loss by exercising greater load on the lower limbs and trunk [32]. Other mechanisms related to obesity may also explain its protective effect such as higher 17β-estradiol [33][34][35] and insulin [36] levels, and some adipokines especially lower adiponectin and higher leptin [37][38][39]. Also, it seems that visceral obesity is influencing mainly trabecular bone [40].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Bone Mineral Density in Post Menopausal Women: Is There Any Link?

Abourazzak¹

2016

JRAD

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“…Previous studies have described various cytokines that are implicated in bone and adipose tissue crosstalk [17,18].…”

Section: Discussionmentioning

confidence: 99%

Serum Omentin-1 Concentrations are Significantly and Independently related to Carotid Intima:Media Thickness in Postmenopausal Saudi Women

Alissa

2015

Journal of Bone Biology and Osteoporosis

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Purpose: Cytokines and hormones derived from adipose tissue are implicated in bone metabolism and atherogenesis. There is little data on the relationship between serum omentin-1 and vascular disease. We aimed to investigate the relationship between levels of serum omentin-1 and bone profile parameters in Saudi postmenopausal females with and without subclinical atherosclerosis.Methods: 126 postmenopausal women were recruited from the King Abdulaziz University Hospital in a casecontrol study design. Measurements were made of clinical biomarkers, including carotid intima: media thickness (CIMT) for all subjects.Results: Serum omentin-1 levels were higher amongst postmenopausal women with subclinical carotid atherosclerosis than their age-matched controls (p<0.05). Only body weight and mean CIMT were shown to be independent predictors of serum omentin-1 levels by explaining 10.6% of the total variance according to the multiple regression model. Conclusion:Serum omentin-1 levels are higher in postmenopausal women with evidence of early carotid atherosclerosis as assessed by CIMT and negatively associated with body weight.

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Influence of Adipokines and Ghrelin on Bone Mineral Density and Fracture Risk: A Systematic Review and Meta-Analysis

Abstract: Adiponectin is the most relevant adipokine negatively associated with BMD, independent of gender and menopausal status. Inconsistent associations between adipokines and BMD are probably confounded by body composition, in particular fat mass parameters.

Cited by 210 publications

References 95 publications

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Metabolic Syndrome and Bone Mineral Density in Post Menopausal Women: Is There Any Link?

Serum Omentin-1 Concentrations are Significantly and Independently related to Carotid Intima:Media Thickness in Postmenopausal Saudi Women

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