Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint

Kawai, Nobuhiko; Tanaka, Eiji; Takata, Takashi; Miyauchi, Mutsumi; Tanaka, Masao; Todoh, Masahiro; Eijden, Theo van; Tanne, Kazuo

doi:10.1002/jbm.a.30078

Cited by 43 publications

(48 citation statements)

References 22 publications

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“…38,88,182 In synovial fluid, HA with high molecular weight released by type B synovial cells is generally believed to be essential for lubrication of joints by reducing friction. 22,129 Meanwhile, in joints afflicted with OA, the synovial fluid has reduced viscosity due to the decrease in both concentration and molecular weight of HA 84,110 (see Part 2).…”

Section: Synovial Fluidmentioning

confidence: 99%

“…This fluid acts as a lubricant in the upper and lower compartments of the TMJ as well as acting as a vehicle for nutrients as it passes through the surface layers of the disc and articular cartilage layers. 84,165 The collagen and proteoglycans are dispersed in the fluid, making the cartilage a microporous material with a certain permeability. The mechanical response of the disc to compression depends on the permeability.…”

Section: Synovial Fluidmentioning

confidence: 99%

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Lubrication of the Temporomandibular Joint

et al. 2007

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Although tissue engineering of the temporomandibular joint (TMJ) structures is in its infancy, tissue engineering provides the revolutionary possibility for treatment of temporomandibular disorders (TMDs). Recently, several reviews have provided a summary of knowledge of TMJ structure and function at the biochemical, cellular, or mechanical level for tissue engineering of mandibular cartilage, bone and the TMJ disc. As the TMJ enables large relative movements, joint lubrication can be considered of great importance for an understanding of the dynamics of the TMJ. The tribological characteristics of the TMJ are essential for reconstruction and tissue engineering of the joint. The purpose of this review is to provide a summary of advances relevant to the tribological characteristics of the TMJ and to serve as a reference for future research in this field. This review consists of four parts. Part 1 is a brief review of the anatomy and function of the TMJ articular components. In Part 2, the biomechanical and biochemical factors associated with joint lubrication are described: the articular surface topology with microscopic surface roughness and the biomechanical loading during jaw movements. Part 3 includes lubrication theories and possible mechanisms for breakdown of joint lubrication. Finally, in Part 4, the requirement and possibility of tissue engineering for treatment of TMDs with degenerative changes as a future treatment regimen will be discussed in a tribological context.

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Section: Synovial Fluidmentioning

confidence: 99%

Section: Synovial Fluidmentioning

confidence: 99%

Lubrication of the Temporomandibular Joint

et al. 2007

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“…1a, b;Kawai et al 2004). Twenty mandibular condyles obtained from 20 pigs were randomly divided into two groups: the control and experimental groups (n=10 in each).…”

Section: Measurement Of Friction Coefficient Of Mandibular Condylar Cmentioning

confidence: 97%

Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage

et al. 2011

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We examined the localization and boundary lubricating function of superficial zone protein (SZP) on the surface of mandibular condylar cartilage. Chondrocytes were separated from the surface layer of mandibular condylar cartilage of 6- to 9-month-old female pigs. A cyclic tensile strain of 7% or 21% cell elongation was applied to the cultured chondrocytes. Gene expression levels of cartilage matrix proteins and secretory phospholipase A(2) (sPLA(2)) were quantified by real-time polymerase chain reaction analysis. The friction coefficient of the mandibular condylar surface was measured by a friction tester before and after treatment with 0.1 U/ml sPLA(2). Significantly higher mRNA levels of SZP and type I collagen were found in chondrocytes from the superficial layer than in those in the other layers. The SZP mRNA level was up-regulated by cyclic tensile strain of 7% and 21% cell elongation. Cyclic tensile strain of 21% cell elongation up-regulated the sPLA(2) mRNA level. The friction coefficient of the condylar surface was increased significantly by treatment with sPLA(2). The removal of SZP from the surface layer of mandibular condylar cartilage by sPLA(2) resulted in a significant increase in the friction coefficient on the surface of articular cartilage.

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“…L'AI, che rappresenta il principale componente del liquido sinoviale (LS), possiede un ruolo importante nell'omeostasi articolare, sia per le importanti proprietà visco-elastiche che conferisce al LS, sia per il suo effetto analgesico ed antinfiammatorio (5)(6)(7). L'AI, infatti, è in grado di ridurre la produzione di sostanze pro-infiammatorie (8) e la permeabilità vascolare (9), di inibire la migrazione di cellule infiammatorie e di proteggere dal danno cellulare mediato dai radicali liberi (10).…”

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Influence of intra-articular injections of sodium hyaluronate on clinical features and synovial fluid nitric oxide levels of temporomandibular osteoarthritis

Guarda-Nardini¹,

Oliviero²,

Ramonda³

et al. 2011

Reumatismo

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artrosi od osteoartrosi (OA) rappresenta l'artropatia più comune dell'articolazione temporo-mandibolare (ATM) (1). Come per le altre localizzazioni, anche l'OA dell'ATM riconosce una patogenesi multifattoriale, caratterizzata dalla degradazione progressiva della cartilagine articolare e da alterazioni dell'osso subcondrale. A differenza di altre articolazioni, le manifestazioni degenerative a carico dell'ATM si riscontrano prevalentemente nel sesso femminile (2). La sintomatologia è frequentemente caratterizzata da dolorabilità alla palpazione, rumori articolari, in particolare crepitii, riduzione della motilità mandibolare e dolore nell'esecuzione dei normali movimenti. La terapia dell'OA dell'ATM è tutt'oggi controversa soprattutto quando la gravità della malattia non è tale da giustificare interventi aggressivi. Fra le terapie locali più efficaci, soprattutto quando vi è un interessamento monoarticolare, vi sono le infiltrazioni intra-articolari. I farmaci più comunemente utilizzati a tale scopo sono i cortisonici che, tuttavia, non sempre sono efficaci e, secondo alcuni (3), possono essere condrolesivi nel tempo. La LAVORO ORIGINALE Reumatismo, 2004; 56(4):272-277 Indirizzo per la corrispondenza: Dott. Luca Guarda Nardini Cattedra e Divisione di Chirurgia Maxillo-facciale Azienda Università di Padova Via Giustiniani 2, 35128 Padova E-mail: luca.guarda@unipd.it Reumatismo, 2004; 56(4):272-277 SUMMARY Objective: This study was designed to assess the effect of intra-articular injection of sodium hyaluronate (SH) on clinical findings of temporomandibular osteoarthritis (OA) and on synovial fluid (SF) levels of nitric oxide (NO). Methods: Twenty seven patients (7 men, 20 women, mean (SD) age 53.9 (11.8) years) with OA of the temporomandibular joint were randomly allocated to receive an injection of either SH (2ml, Hyalgan®

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Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint

Cited by 43 publications

References 22 publications

Lubrication of the Temporomandibular Joint

Lubrication of the Temporomandibular Joint

Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage

Influence of intra-articular injections of sodium hyaluronate on clinical features and synovial fluid nitric oxide levels of temporomandibular osteoarthritis

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