Influence of Acute Multispecies and Multistrain Probiotic Supplementation on Cardiovascular Function and Reactivity to Psychological Stress in Young Adults: A Double-Blind, Randomized, Placebo-Controlled Trial

Möller, Clara; Olsa, Eamon J.A.; Ginty, Annie T.; Rapelje, Alyssa L.; Tindall, Christina L.; Holesh, Laura A.; Petersen, Karen L.; Conklin, Sarah M.

doi:10.1097/psy.0000000000000489

Cited by 23 publications

(28 citation statements)

References 47 publications

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“…alpha-amylase) markers. The cardiovascular, hormonal, and psychological measures of stress indicated that stress was reliably induced, but were themselves not influenced by the probiotics, which is in line with previous studies (Mohammadi et al, 2016; Kelly et al, 2017; Moller et al, 2017) but see (Allen et al, 2016). If the current multi-species probiotic product indeed strengthened epithelial barrier function, as demonstrated in vitro (Van Hemert 2014), then other mechanisms could underlie the currently observed effects.…”

Section: Discussionsupporting

confidence: 90%

Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

Papalini

Michels

Kohn

et al. 2019

Neurobiology of Stress

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Probiotics are microorganisms that provide health benefits when consumed. In animals, probiotics reverse gut microbiome-related alterations in depression-like symptoms, in cognition, and in hormonal stress response. However, in humans, a causal understanding of the gut-brain link in emotion and cognition is lacking. Additionally, whether the effects of probiotics on neurocognition are visible only in presence of stress, remains unclear. We investigated the effects of a multispecies probiotic (Ecologic®Barrier) on specific neurocognitive measures of emotion reactivity, emotion regulation, and cognitive control using fMRI. Critically, we also tested whether probiotics can buffer against the detrimental effects of acute stress on working memory. In a double blind, randomized, placebo-controlled, between-subjects intervention study, 58 healthy participants were tested once before and once after a 28-day intervention.Without stress induction, probiotics did not affect brain, behavioral, or related self-report measures. However, relative to placebo, the probiotics group did show a significant stress-related increase in working memory performance after supplementation. This change was associated with intervention-related neural changes in frontal cortex during cognitive control exclusively in the probiotics group. Overall, our results show neurocognitive effects of a multispecies probiotic in healthy women only under challenging situations, buffering against the detrimental effects of stress on cognition.

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Section: Discussionsupporting

confidence: 90%

Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

Papalini

Michels

Kohn

et al. 2019

Neurobiology of Stress

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“…the socially evaluated cold pressor test (SECPT), fewer self-reported anxiety symptoms were observed after 4 weeks of Bifidobacterium longum 1714 use than after placebo 21 . In contrast, in two other RTCs in healthy volunteers, no alterations in stress-related measures were observed after two-weeks supplementation of Lactobacilli, Bifidobacteria and Streptococci strains 22 or after eight-week Lactobacillus rhamnosus supplementation 23 . Thus, although probiotics have been shown to affect human stress-related measures in some studies, the effects are not always replicated and more research is needed to understand the mechanisms behind these effects.…”

Section: Introductionmentioning

confidence: 58%

Probiotics-induced changes in gut microbial composition and its effects on cognitive performance after stress

Bloemendaal

Belzer

Boverhoff

et al. 2020

Preprint

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Stress negatively affects cognitive performance. Probiotics remediate somatic and behavioral stress responses, hypothetically by acting on the gut microbiota. Here, we assessed gut microbial alterations after 28-days supplementation of multi-strain probiotics (EcologicBarrier consisting of Lactobacilli, Lactococci and Bifidobacteria in healthy, female subjects (probiotics group n=27, placebo group n=29). In an identical pre- and post-session, subjects performed a working memory task before and after an acute stress intervention. One-month supplementation of probiotics changed the gut microbial community (within probiotics group Pweighted unifrac=0.008). This change was driven by a nominal increase in eight genera in the probiotics group relative to the placebo group: Butyricimonas, Parabacteroides, Alistipes, Christensenellaceae_R-7_group, Family_XIII_AD3011_group, Ruminococcaceae_UCG-003, Ruminococcaceae_UCG-005 and Ruminococcaceae_UCG-010. Of these, the probiotics-induced change in genus Ruminococcaceae_UCG-003 was significantly associated with probiotics’ effect on stress-induced working memory changes (rspearman(27) = 0.565; pFDR = 0.014) in the probiotics group only and independent of potential confounders (i.e., age, BMI, and baseline dietary fibre intake). That is, subjects with a higher increase in Ruminococcaceae_UCG-003 abundance after probiotics were also more protected from negative effects of stress on working memory after probiotic supplementation. The bacterial taxa showing an increase in relative abundance in the probiotics group are plant fibre degrading bacteria and produce short-chain fatty acids that are known for their beneficial effect on gut and brain health, e.g. maintaining intestinal- and blood-brain-barrier integrity. This study shows that gut microbial alterations, modulated through probiotics use, are related to improved cognitive performance in acute stress circumstances.

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“…Other trials have not shown howbeit a positive effect of probiotics in the stressmodulation. Thus, the daily administration of a multistrain and multispecies probiotics probiotic ((B. breve, B.longum, B. infantis, L. acidophilus, L. plantarum, L. paracasei, L. bulgaricus, and S. thermophilus)) during 2 weeks have not shown an influence on psychological reactions to acute psychological stress during post stress recovery in young adults (Möller et al, 2017).…”

Section: Insert Table 2 Around Here Probioticsmentioning

confidence: 95%

Stress and the gut microbiota-brain axis

Molina-Torres

Rodriguez‐Arrastia²,

Román³

et al. 2019

Behavioural Pharmacology

114

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Stress is a nonspecific response of the body to any demand imposed upon it, disrupting the body homeostasis and that manifests with symptoms such as anxiety, depression or even headache. Response, which is quite frequent in the present competitive world. The aim of this review is to explore the impact of stress on gut-microbiota. Firstly, we summarize evidences in which the microbiota composition has changed as response of a stress situation, thus microbiota impact by stress-response. Likewise, we summarize the different interventions that can modulate microbiota and so then could modulate the stress according to the underlying mechanisms that involved the gut-brain axis on the stress. Finally, we show evidence through the gut modulation impact on stress, both preclinical and clinical studies. In conclusion, the influence of stress on gut-microbiota and gutmicrobiota on stress modulation is clear through different stressors, although the preclinical evidence is so extended, the clinical evidence is more limited. A better understanding of the mechanism underlying the stress modulation through the microbiota may open new avenues for the design of therapeutics that could enhance the clinical benefits pursued. Not only on stress, but also on stress-related disorders such as anxiety and depression, both in healthy subjects and in different populations.

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Influence of Acute Multispecies and Multistrain Probiotic Supplementation on Cardiovascular Function and Reactivity to Psychological Stress in Young Adults: A Double-Blind, Randomized, Placebo-Controlled Trial

Cited by 23 publications

References 47 publications

Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

Probiotics-induced changes in gut microbial composition and its effects on cognitive performance after stress

Stress and the gut microbiota-brain axis

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