Influence of Acute Exercise on Urinary Protein, Creatinine, Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 Concentrations in Children

Abstract

Insulin-like growth factor-I (IGF-I) is a polypeptide hormone and present in human urine. Insulin-like growth factor binding protein-3 (IGFBP-3) is the major form of binding protein in human circulation and functions as a carrier for IGF-I. Our goal was to determine the effects of volleyball exercise on the concentrations of urine protein, creatinine, IGF-I, and IGFBP-3 in children and to find out whether these effects differ between boys and girls. Volunteer children (13 females and 14 males), aged 10-13 years old were included in this work. Weight and height of the subjects were measured, and urine samples of their were collected before and after 2 hours of exercise. Urinary protein, creatinine, IGF-I and IGFBP-3 levels were analysed. Urinary protein, creatinine and IGF-I concentrations were increased after two hours of exercise wheres urinary IGFBP-3 concentrations did not change. In addition, no statistically significant difference in all parameters analysed was observed between boys and girls of similar age and body mass index.

Increased Plasma Levels of Growth Hormone, Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein 3 in Pregnant Rats with Exercise

“…Plasma IGF-I response to physical exercise has not been demonstrated consistently; some research groups have observed increments, while others showed no variations (Di Luigi et al 1997;Nguyen et al 1998;Wallace et al 1999;Turgut et al 2003). This may be due to the different type and duration of the performance and training conducted.…”

Nível de desidratação após treinamento de ciclismo indoor

“…Se os sujeitos se encontram em um estado hipohidratado, a proteína é excretada devido à diminuição do volume plasmático. A proteína presente na urina também acontece devido ao estresse causado pelo exercício e parece ser induzida por um aumento no sangue de ácidos, que levam a alterações na molécula de albumina 14 . Talvez a intensidade do treinamento de ciclismo indoor não tenha provocado um grande estresse fisiológico, pois a FC e a PSE apresentaram um comportamento em níveis moderados até 30-35 minutos de treinamento, só após este tempo apresentaram elevações significativas (FC: >85%; PSE: >13).…”

“…Existe uma relação do nível de proteinúria e o estado de hidratação do indivíduo, sendo que a presença de proteínas na urina tende a ser maior de acordo com o aumento do grau de desidratação 14 .…”

Usefulness of the Thyrotropin-Releasing Hormone Test in Pre-Clinical Acromegaly

“…The serum IGF-I level would be a better reliable indicator for screening of acromegaly, because it reflects overall GH secretion during the previous 24 h ( Thorner et al 1998). However, the normal range for serum IGF-I levels varies with age and gender, and should be corrected for them (Turgut et al 2003). Furthermore, IGF-I level also reflects the liver function and the nutrition status.…”