Influence of Acute Administration of Human Growth Hormone and Alpha-MSH on Plasma Concentrations of Aldosterone, Cortisol, Corticosterone and Growth Hormone in Man

Birkhäuser, Martin; Gaillard, Rolf C.; Riondel, A. M.; Zahnd, G

doi:10.1530/acta.0.0790016

Cited by 22 publications

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“…Nevertheless such changes do also occur. However, no changes in basal or insulin-induced hypoglycaemia stimulated cortisol have been reported after short-term GH treatment in normal volunteers, hypopituitary patients or adults during nutritional repletion (Abrams et al, 1971;Birkhauser et al, 1975;Ziegler et al, 1991). GH has a synergistic effect on ACTH action on the biosynthesis of cortisol in the adrenal (Castro-Magana et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

guez-Arnao¹,

Perry²,

Besser³

et al. 1996

Clin Endocrinol

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OBJECTIVES Patlents wlth GH deficlency frequently have multiple hormone deficiencies and require hydrocortisone replacement. We have investigated whether GH treatment alters circulating cortisol levels in hypopituitary patients recelving stable replacement therapy. DESIGN SubJects were studied during 6 or 12 months of S.C. GH at a dose of 0.25 IUlkglweek (0.125 IUlkglweek for the first 4 weeks), and efter a wash-out period of at least 2 months off GH (range 2-5 months). PATIENTS Fourteen hypopituitary patients (2F:12M) receivlng stable hydrocortisone replacement and thyroxlne, gonadal steroids and bromocriptlne therapy as required. MEASUREMENTS Serum cortisol values were measured throughout the day over 105 hours. Thyrold hormones and cortlsol binding globulin (CBG) were measured in the baseline sample. Comparisons of the serum cortlsol peak after receiving the flrst dose of hydrocortlsone, the tlme when the serum cortlsol peak was obtained, the area under the curve (AUC) for the cortlsol values and the levels of unbound cortisol on and off OH therapy were made. The results are expressed as mean * SEM.Comparisons were carried out within lndivlduals, uslng the Wilcoxon signed rank test. A P-value less than 0.05 was consldered statistically signlflcant. RESULTS During OH therapy, there was a significant reductlon in the mean cortisol peak (662.2f 61.1 vs 848.0 f 58.6 nmol/l; P = 0.001), and In the AUC for cortisol t (185.3 f 18.3 vs 230 * 17.9 nmol/l/l0~5h; P = 0.03), but there was no signlflcant change in the tlme of the cortisol peak (55.7 f 7.6 vs 57.8 f 4.9 minutes; P = NS). Durlng GH therapy there was a significant reductlon In CBG levels (33.64 i 1-16 vs 40-86 f 1-34mg/l; P = 0.001); however, no changes were found In the levels of calculated unbound cortlsol on and off GH (2.87f0.38 vs 2.90 f 0.30 nmol/l; P = NS). Durlng OH therapy, there was a slgnificant increase In serum trilodothyronlne (T3) (1.88 f 0.15 vs 1-44 i 0.11 nmol/l; P = 0-Ol), and a significant decrease in thyroxlne (T4) levels (74.9 * 11.1 vs 97.6 + i 10.9 nmol/l; P = 0.02) but levels remained within the normal range. No change was observed in serum TSH levels (0.29 f 0.13 vs 0.83 & 0.71 mU/I;CONCLUSIONS These results suggest that OH therapy In GH deflclent adults produces an alteration in the measured serum cortisol proflle, with a reduction in concentration of total cortisol in blood after rrally admlnlstered hydrocortisone. These changes in circulatlng cortlsol probably depend primarily on the fall in CBG levels, as no changes were found in the levels of calculated unbound cortisol on and off GH. Our data show that when measuring circulating cortisol levels, the results should be interpreted with caution in OH deflclent patients on GH replacement, and different criteria may have to be applied to the circulating cortlsol profile of these patients. The results hlghllght the importance of ensuring adequate cortlcosteroid replacement in patients starilng GH therapy. P = NS).

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Section: Discussionmentioning

confidence: 99%

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

guez-Arnao¹,

Perry²,

Besser³

et al. 1996

Clin Endocrinol

View full text Add to dashboard Cite

show abstract

“…GH has a synergistic effect on ACTH action on the biosynthesis of cortisol in the adrenal (Castro-Magana et al, 1983). However, no changes in basal or insulin-induced hypoglycaemia stimulated cortisol have been reported after short-term GH treatment in normal volunteers, hypopituitary patients or adults during nutritional repletion (Abrams et al, 1971;Birkhauser et al, 1975;Ziegler et al, 1991). The effect on cortisol metabolism has been less well studied.…”

Section: Discussionmentioning

confidence: 99%

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

Rodriguez-Arnao

Perry

Besser

et al. 1996

Clinical Endocrinology

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These results suggest that GH therapy in GH deficient adults produces an alteration in the measured serum cortisol profile, with a reduction in concentration of total cortisol in blood after orally administered hydrocortisone. These changes in circulating cortisol probably depend primarily on the fall in CBG levels, as no changes were found in the levels of calculated unbound cortisol on and off GH. Our data show that when measuring circulating cortisol levels, the results should be interpreted with caution in GH deficient patients on GH replacement, and different criteria may have to be applied to the circulating cortisol profile of these patients. The results highlight the importance of ensuring adequate corticosteroid replacement in patients starting GH therapy.

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“…The regulation of lipogenesis of sebaceous glands seems to be mediated by a-MSH in the intermediate lobe of the pituitary (16,17). However, the increased turnover of serotonin in the cerebral cortex of the rat after chronic sc treatment with a-MSH (18), the increased rate of protein synthesis in certain brain regions after ip injection of peptides with melanosome-dispersing activity in the mouse (19), and the stimulating effect of iv injected a-MSH on secretion of GH in human subjects (20)(21)(22) may be mediated by a-MSH in the brain. The radioautographic localization of [ 125 I]iodo-MSH in the rat brain has indicated the presence of a-MSH receptors in the striatum and in the reticular nucleus of the hypothalamus (23).…”

Section: Discussionmentioning

confidence: 99%

Localization of α-Melanocyte-Stimulating Hormone in Rat Brain and Pituitary

et al. 1978

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The distribution of alpha-melanocyte-stimulating hormone (alpha-MSH) was studied in the rat brain with an immunoperoxidase technique. alpha-MSH-containing cells were found in the arcuate nucleus of the hypothalamus. Cells staining for alpha-MSH were also localized in the intermediate lobe of the pituitary. alpha-MSH-containing nerve fibers extended throughout regions of the hypothalamus, thalamus, and midbrain. Two weeks after hypophysectomy, alpha-MSH-positive cells anf fibers were still present in the brain. These results indicate that alpha-MSH of non-pituitary origin is synthesized and stored by neural structures in the rat brain. The detection of alpha-MSH by radioimmunoassay in the rat brain and pituitary supports these observations.

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Influence of Acute Administration of Human Growth Hormone and Alpha-MSH on Plasma Concentrations of Aldosterone, Cortisol, Corticosterone and Growth Hormone in Man

Cited by 22 publications

References 0 publications

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

Growth hormone treatment in hypopituitary GH deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy

Localization of α-Melanocyte-Stimulating Hormone in Rat Brain and Pituitary

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