Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice

Tong, Haiyan; McGee, John K.; Saxena, Rajiv K.; Kodavanti, Urmila P.; Devlin, Robert B.; Gilmour, M. Ian

doi:10.1016/j.taap.2009.05.019

Cited by 98 publications

(68 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been proposed that the type of carbon nanomaterial (i.e., SW-CNT, MW-CNT, and fullerene), method of production (i.e., chemical vapor deposition, arc discharge, and laser ablation), extent of purity (i.e., refined or unrefined), presence of residual transition metal catalysts, functionality of different reactive groups, dimension, and method of administration can influence the health effects observed with these nanomaterials (Lam et al 2004;Muller et al 2005;Dumortier et al 2006;Magrez et al 2006;Tian et al 2006;Sayes et al 2007;Muller et al 2008;Poland et al 2008;Shvedova et al 2008;Tong et al 2009). One novel characteristic, however, that has gained some consideration is the potential role of carbon bond defects and acid functional groups in eliciting inflammatory and fibrotic responses with exposure to MW-CNTs .…”

Section: Discussionmentioning

confidence: 99%

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Madl

Teague²,

et al. 2012

Aerosol Science and Technology

View full text Add to dashboard Cite

Assessing the human health risks associated with engineered nanomaterials is challenging because of the wide range of plausible exposure scenarios. While exposure to nanomaterials may occur through a number of pathways, inhalation is likely one of the most significant potential routes of exposure in industrial settings. An aerosolization system was developed to administer carbon nanomaterials from a dry bulk medium into airborne particles for delivery into a nose-only inhalation system. Utilization of a cannula-based feed system, diamond-coated wheel, aerosolization chamber, and krypton-85 source allows for delivery of otherwise difficult to produce respirable-sized particles. The particle size distribution (aerodynamic and actual) and morphology were characterized for different aerosolized carbon-based nanomaterials (e.g., single-walled carbon nanotubes and ultrafine carbon black). Airborne particles represented a range of size and morphological characteristics, all of which were agglomerated particles spanning in actual size from the nanosize range (<0.1 µm) to sizes greater than 5 and 10 µm for the particle's largest dimension. At a mass concentration of 1000 µg/m 3 , the size distribution as measured by the inertial impactor ranged from 1.3 to 1.7 µm with a σ g between 1.2 and 1.4 for all nanomaterial types. Because the aerodynamic size distribution is similar across different particle types, this system offers an opportunity to explore mechanisms by which different nanomaterial physicochemical characteristics impart different health effects while theoretically maintaining comparable deposition patterns in the lungs. This sys-

show abstract

Section: Discussionmentioning

confidence: 99%

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Madl

Teague²,

et al. 2012

Aerosol Science and Technology

View full text Add to dashboard Cite

show abstract

“…For that reason, we have decided to study the inflammatory response to pristine DWCNT in general, rather than that of a specific functionalization. On a related note, it may be mentioned that COOH-functionalized SWCNTs have been shown to be even less biocompatible and more toxic than the corresponding pristine specimen [32][33][34].…”

Section: Dwcnt Cause Persistent Alveolar Inflammationmentioning

confidence: 99%

Pulmonary DWCNT exposure causes sustained local and low-level systemic inflammatory changes in mice

Tian¹,

Habel²,

Yin³

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

“…Such approaches are essential for the further development and safe use of CNTs at the occupational level as well as at the level of the general user. From various studies of the toxicity of CNTs, it is clear that surface modifications are important to minimize CNT toxicity [163][164][165][166][167]. A coating could be a useful tool, as it allows modification of the external surface environment of CNTs without affecting their intrinsic structure or basic properties.…”

Section: Toxicity Of Cnts and Its Controlmentioning

confidence: 99%

Carbon nanotubes-properties and applications: a review

Ibrahim¹

2013

Carbon letters

372

122

View full text Add to dashboard Cite

The carbon nanotube (CNT) represents one of the most unique inventions in the field of nanotechnology. CNTs have been studied closely over the last two decades by many researchers around the world due to their great potential in different fields. CNTs are rolled graphene with SP 2 hybridization. The important aspects of CNTs are their light weight, small size with a high aspect ratio, good tensile strength, and good conducting characteristics, which make them useful as fillers in different materials such as polymers, metallic surfaces and ceramics. CNTs also have potential applications in the field of nanotechnology, nanomedicine, transistors, actuators, sensors, membranes, and capacitors. There are various techniques which can be used for the synthesis of CNTs. These include the arc-discharge method, chemical vaporize deposition (CVD), the laser ablation method, and the sol gel method. CNTs can be single-walled, double-walled and multi-walled. CNTs have unique mechanical, electrical and optical properties, all of which have been extensively studied. The present review is focused on the synthesis, functionalization, properties and applications of CNTs. The toxic effect of CNTs is also presented in a summarized form.

show abstract

Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice

Cited by 98 publications

References 30 publications

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Pulmonary DWCNT exposure causes sustained local and low-level systemic inflammatory changes in mice

Carbon nanotubes-properties and applications: a review

Contact Info

Product

Resources

About