Influence of Acetylated Annealed Starch on the Release of β-Escin from the Anionic and Non-Ionic Hydrophilic Gels

Kobryń, Justyna; Zięba, Tomasz; Sowa, Sandra Karolina; Musiał, Witold

doi:10.3390/pharmaceutics12010084

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…Because the number of parameters was not identical for each model, and R 2 increases with increasing numbers of parameters, for the selection of the mathematical model which fits best on the experimental data, it was necessary to use the adjusted correlation coefficient (R 2 adj ) [ 56 , 57 ]. This formula was used: R 2 adjusted = 1 − (( n − 1) × (1 − R2))/( n p − 1), where “p” is the number of parameters in the model and “ n ” is the number of experimental data points [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Some preview studies confirm that the Higuchi model best fits the release profile of the Curcumin from microemulsion [ 55 , 56 ]. According to the Higuchi model, the active principle is homogeneously dispersed and the release, from these three selected samples, is achieved by pure diffusion and without erosion or swelling of the matrix [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

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Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

et al. 2021

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Gel microemulsion combines the advantages of the microemulsion, which can encapsulate, protect and deliver large quantities of active ingredients, and the gel, which is so appreciated in the cosmetic industry. This study aimed to develop and characterize new gel microemulsions suitable for topical cosmetic applications, using grape seed oil as the oily phase, which is often employed in pharmaceuticals, especially in cosmetics. The optimized microemulsion was formulated using Tween 80 and Plurol® Diisostearique CG as a surfactant mix and ethanol as a co-solvent. Three different water-soluble polymers were selected in order to increase the viscosity of the microemulsion: Carbopol® 980 NF, chitosan, and sodium hyaluronate salt. All used ingredients are safe, biocompatible and biodegradable. Curcumin was chosen as a model drug. The obtained systems were physico-chemically characterized by means of electrical conductivity, dynamic light scattering, polarized microscopy and rheometric measurements. Evaluation of the cytotoxicity was accomplished by MTT assay. In the final phase of the study, the release behavior of Curcumin from the optimized microemulsion and two gel microemulsions was evaluated. Additionally, mathematical models were applied to establish the kinetic release mechanism. The obtained gel microemulsions could be effective systems for incorporation and controlled release of the hydrophobic active ingredients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

et al. 2021

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“…9.0, 20903 (01/2016)]. The released drug amount was assessed via spectrophotometry (Spectrophotometer UV/VIS Jasco V-530, Tokyo, Japan) according to the available bibliography [ 42 , 43 ].…”

Section: Methodsmentioning

confidence: 99%

The Annealing of Acetylated Potato Starch with Various Substitution Degrees

et al. 2021

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This study aimed to determine the effect of “annealing” acetylated potato starch with a homogenous granule size and various degrees of substitution on the thermal pasting characteristics (DSC), resistance to amylases, rheology of the prepared pastes, swelling power and dynamics of drug release. A fraction of large granules was separated from native starch with the sedimentation method and acetylated with various doses of acetic anhydride (6.5, 13.0 or 26.0 26 cm3/100 g starch). The starch acetates were then annealed at slightly lower temperatures than their pasting temperatures. The annealing process caused an almost twofold increase in the resistance to amylolysis and a threefold increase in the swelling power of the modified starch preparations. The heat of phase transition decreased almost two times and the range of starch pasting temperatures over two times, but the pasting temperature itself increased by ca. 10 °C. The 40 g/100 g addition of the modified starch preparation decreased the rate of drug release from a hydrogel by ca. one-fourth compared to the control sample.

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“…Then, the zero-order model, First-order model, Higuchi model, Ritger-Peppas model, and Weibull model were used to model the Rhy and Rhy-SLNs release kinetics as previously described [25,26].…”

Section: Rhy-slns/rhy Release and Release Kineticsmentioning

confidence: 99%

Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway

Li²,

Cui

et al. 2021

Bioengineered

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Allergic asthma is one of the most common chronic airway diseases, and there is still a lack of effective drugs for the treatment of allergic asthma. The purpose of this work is to formulate rhynchophylline (Rhy)-solid lipid nanoparticles (SLNs) to improve their therapeutic efficacy in a mice allergic model of asthma. A solvent injection method was employed to prepare the Rhy-SLNs. Physicochemical characterization of Rhy-SLNs was measured, and the release assessment was investigated, followed by the release kinetics. Next, a model of murine experimental asthma was established. Mice were subcutaneously injected with 20 μg ovalbumin mixed with 1 mg aluminum hydroxide on days 0, 14, 28, and 42 and administrated aerosolized 1% ovalbumin (w/v) by inhalation from day 21 to day 42. Mice were intraperitoneally injected with 20 mg/kg Rhy-SLNs or Rhy at one hour before the airway challenge with ovalbumin. The results showed that Rhy-SLNs revealed a mean particle size of 62.06 ± 1.62 nm with a zeta potential value of -6.53 ± 0.04 mV and 82.6 ± 1.8% drug entrapment efficiency.The release curve of Rhy-SLNs was much higher than the drug released in phosphate buffer saline at 0, 1, 1.5, 2, 4, or 6 h. Moreover, Rhy-SLNs exerted better effects on inhibiting ovalbumin-induced airway inflammation, oxidative stress, airway remodeling (including collagen deposition and mucus gland hyperplasia) than Rhy in murine experimental asthma. Subsequently, we found that Rhy-SLNs relieved allergic asthma via the upregulation of the suppressor of cytokine signaling 1 by repressing the p38 signaling pathway.

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Influence of Acetylated Annealed Starch on the Release of β-Escin from the Anionic and Non-Ionic Hydrophilic Gels

Cited by 13 publications

References 33 publications

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

The Annealing of Acetylated Potato Starch with Various Substitution Degrees

Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway

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