Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Mostafavi, Sayed Abolfazl; Lewanczuk, Richard; Foster, Robert T.

doi:10.1002/1099-081x(200005)21:4<121::aid-bdd216>3.0.co;2-y

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…There was no significant difference in hepatic arterial and portal blood flow between rats with and without the ileal and hepatic portal vein catheterizations. These blood flow values are in the range of those reported by others (23,24,29,34,46). Furthermore, hepatic portal blood flow increased in response to intraduodenal glucose infusion at increments that were similar between rats with and without the ileal and hepatic portal vein catheterizations.…”

Section: Resultssupporting

confidence: 84%

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

Chu¹,

Fujimoto²,

Igawa³

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

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The rate of liver glucokinase (GK) translocation from the nucleus to the cytoplasm in response to intraduodenal glucose infusion and the effect of physiological rises of plasma glucose and/or insulin on GK translocation were examined in 6-h-fasted conscious rats. Intraduodenal glucose infusion (28 mg.kg(-1).min(-1) after a priming dose at 500 mg/kg) elevated blood glucose levels (mg/dl) in the artery and portal vein from 90 +/- 3 and 87 +/- 3 to 154 +/- 4 and 185 +/- 4, respectively, at 10 min. At 120 min, the levels had decreased to 133 +/- 6 and 156 +/- 5, respectively. Plasma insulin levels (ng/ml) in the artery and the portal vein rose from 0.7 +/- 0.1 and 1.8 +/- 0.3 to 11.8 +/- 1.5 and 20.2 +/- 2.0 at 10 min, respectively, and 12.4 +/- 3.1 and 18.0 +/- 4.8 at 30 min, respectively. GK was rapidly exported from the nucleus as determined by measuring the ratio of the nuclear to the cytoplasmic immunofluorescence (N/C) of GK (2.9 +/- 0.3 at 0 min to 1.7 +/- 0.2 at 10 min, 1.5 +/- 0.1 at 20 min, 1.3 +/- 0.1 at 30 min, and 1.3 +/- 0.1 at 120 min). When plasma glucose (arterial; mg/dl) and insulin (arterial; ng/ml) levels were clamped for 30 min at 93 +/- 7 and 0.7 +/- 0.1, 81 +/- 5 and 8.9 +/- 1.3, 175 +/- 5 and 0.7 +/- 0.1, or 162 +/- 5 and 9.2 +/- 1.5, the N/C of GK was 3.0 +/- 0.5, 1.8 +/- 0.1, 1.5 +/- 0.1, and 1.2 +/- 0.1, respectively. The N/C of GK regulatory protein (GKRP) did not change in response to the intraduodenal glucose infusion or the rise in plasma glucose and/or insulin levels. The results suggest that GK but not GKRP translocates rapidly in a manner that corresponds with changes in the hepatic glucose balance in response to glucose ingestion in vivo. Additionally, the translocation of GK is induced by the postprandial rise in plasma glucose and insulin.

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Section: Resultssupporting

confidence: 84%

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

Chu¹,

Fujimoto²,

Igawa³

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Radiopharmaceuticals based on selective β 1 ‐AR are expected to show high heart uptake . Acebutolol (Figure ) is a chiral β 1 ‐AR blocking agent . The aim of the present approach is to build up simple and efficient method for radioiodination of acebutolol by studying the factors that will affect radioiodination process in details and to evaluate biologically the radioiodinated acebutolol as a radiotracer for MPI.…”

Section: Introductionmentioning

confidence: 99%

Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging

Swidan

Sakr

Motaleb

et al. 2014

Labelled Comp Radiopharmac

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Acebutolol was successfully labeled with (125) I via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 ± 0.3% and in vitro stability up to 72 h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 ± 0.14% injected activity/g organ with low lungs and liver uptakes at 5 min post-injection. In vivo receptor blocking study was carried out in mice to evaluate its selectivity to heart. Radioiodinated acebutolol showed fast heart accumulation with high heart/liver ratio, which provides the ability for fast myocardial imaging with significant decrease in the radiation hazards risk on patients. So, radioiodinated acebutolol could be displayed as a radiotracer drug of choice in case of emergency patients for myocardial perfusion imaging.

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Enantiomeric separation of β-blockers by HPLC using (R)-1-naphthylglycine and 3,5-dinitrobenzoic acid as chiral stationary phase

Zhang

Ouyang

Baeyens

et al. 2003

Journal of Pharmaceutical and Biomedical Analysis

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Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Cited by 3 publications

References 31 publications

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging

Enantiomeric separation of β-blockers by HPLC using (R)-1-naphthylglycine and 3,5-dinitrobenzoic acid as chiral stationary phase

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