Abstract:OBJECTIVEIt is unclear whether ACE gene polymorphisms influence the therapeutic outcome of a ACE‐inhibitor therapy. We therefore investigated the role of the ACE I/D polymorphism on 24‐hour blood pressure (ABPM), left ventricular mass index (LVMI) an proteinuria in children following ramipril monotherapy.METHODSSixty children (age 14.4±3.8 years) with various chronic nephropathies and hypertension received ramipril monotherapy (mean maximum dose 5.3±1.6 mg/m2). Their ACE I/D genotype was correlated to results … Show more
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