Influence of a Single Parenteral Application of a 10% Fish Oil Emulsion on Plasma Fatty Acid Pattern and the Function of Thrombocytes in Young Adult Men

Abstract

50 ml of a 10% fish oil emulsion (41% ω-3 fatty acids of total fatty acids) were infused for 1 h into the arm vein of young, healthy, male volunteers. The fatty acid composition of the plasma, aggregation of the blood platelets as well as the thromboxane synthesis, were measured before the beginning of infusion, 20, 60, 120, 360 and 1,440 min after the start of the fat infusion. In the first 60 min, the fatty acid composition of the plasma changed in correspondence with the supplied fatty acid pattern. At the end of the investigation it was again within the normal range. As a result of fat application thromboxane synthesis was reduced and the aggregation of the platelets was inhibited but it was normalized by the 1,440-min value. Fish oil emulsions might be beneficial for parenterally fed patients with a high risk of thrombosis. Therefore the performance of further investigations using a varying dosage and multiple application can be recommended.

Effect of Intravenous ω‐3 Fatty Acid Infusion and Hemodialysis on Fatty Acid Composition of Free Fatty Acids and Phospholipids in Patients With End‐Stage Renal Disease

“…This rapid incorporation of ω‐3 PUFAs into phospholipids after a single modest dose is in agreement with the results from 2 small studies in healthy volunteers 39 , 40 . In one study, 50 mL of an FO emulsion similar to the one used in our study was infused for 1 hour 39 . At the end of infusion, plasma fatty acids had changed in correspondence with the supplied fatty acid pattern.…”

Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions

“…However, the effects of LEs on coagulation have not been extensively assessed. In one study, platelet aggregation was inhibited immediately following intravenous infusion of a fish-oil-based LE to healthy volunteers, but had returned to normal at 24 h [76]. In surgical patients receiving PN, the latency to collagen-induced platelet aggregation and time to maximal platelet aggregation were significantly longer for a soybean-oil-based LE than for a fish-oil-enriched LE; however, adenosine-diphosphate-induced platelet aggregation and bleeding time were unchanged [77].…”

ω‐3 Fatty Acids Have No Impact on Serum Lactate Levels After Major Gastric Cancer Surgery

“…Data from numerous human studies of parenteral ω‐3 FA supplementation in stressed patients have shown that ω‐3 FAs have a major role in decreasing inflammatory response, 18 , 32 have immunomodulatory effects, 17 , 33 have positive effects on hemostatic parameters, 15 , 34 , 35 reverse preexisting PN‐associated liver disease, 36 and reduce systemic inflammatory response and length of hospital stay in patients undergoing gastrointestinal cancer surgery 16 …”

“…It would be valuable to study the effect of ω-3 FAs under conditions of ongoing stress, malperfusion, or impaired lactate clearance. Data from numerous human studies of parenteral ω-3 FA supplementation in stressed patients have shown that ω-3 FAs have a major role in decreasing inflammatory response, 18,32 have immunomodulatory effects, 17,33 have positive effects on hemostatic parameters, 15,34,35 reverse preexisting PN-associated liver disease, 36 and reduce systemic inflammatory response and length of hospital stay in patients undergoing gastrointestinal cancer surgery. 16 Interestingly, a recent study by Bisschop et al 37 demonstrated that major upper gastrointestinal surgery elicits a catabolic response characterized by increased inflammation, glucose production, and protein breakdown.…”