Influence of a new surface modification of intraocular lenses with fluoroalkylsilan on the adherence of endophthalmitis-causing bacteria in vitro

Kienast, Antonia; Kämmerer, Regine; Weiß, Claudia; Klinger, Matthias; Menz, Dirk–Henning; Dresp, J.; Ohgke, H; Solbach, Werner; Laqua, H.; Hoerauf, Hans

doi:10.1007/s00417-005-0242-x

Cited by 6 publications

(4 citation statements)

References 20 publications

(40 reference statements)

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“…7 In this respect, both highly hydrophobic as well as highly hydrophilic surfaces have shown to induce decreased cell adhesion and proliferation. To improve biocompatibility of IOLs, researchers have resorted to surface functionalization with either hydrophilic [8][9][10][11][12][13] or hydrophobic 14,15 moieties. However, all these approaches need elaborate post production processes thus limiting their applicability.…”

Section: Introductionmentioning

confidence: 99%

“Cell adhesion resistant, UV curable, polymer zinc oxide nanocomposite materials for intraocular lens application”

Hussain

Shailaja

Tammishetti

et al. 2017

Polymers for Advanced Techs

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Foldable acrylic lenses are used for surgical replacement of diseased intraocular lens in treatment of cataract. One of the main postsurgical complications of this treatment method is postcapsular opacification caused by proliferating epithelial cells. The most common approach taken by research community to address this issue has been modification of lens surface with hydrophobic or hydrophilic moieties to manipulate surface cell interaction. In the present study, inherently cell repellent photopolymer resins are presented. Taking advantage of zinc oxide antiproliferative properties, its nanocomposite resins were made and investigated. Hydrophobically modified zinc oxide nanoparticles and poly(phenylethylacrylate‐co‐phenylethyl methacrylate) were made, and their nanocomposite films were prepared by UV polymerization. Films made with 5 wt% ZnO nanoparticles in them resisted fibroblast attachment substantially. In addition, these films filtered harmful UV light and showed other necessary properties like visible light transparency, glass transition temperatures, mechanical strength, and biocompatibility necessary for making intraocular lenses.

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Section: Introductionmentioning

confidence: 99%

“Cell adhesion resistant, UV curable, polymer zinc oxide nanocomposite materials for intraocular lens application”

Hussain

Shailaja

Tammishetti

et al. 2017

Polymers for Advanced Techs

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“…Surface-initiated chemical reactions, graft polymerization on SAM interfaces, and functionalization are all employed to promote SAM formation on the surfaces of biomaterials. SAMs have been found to be very useful for achieving controlled cell responses [3,8,[15][16][17], anti-fouling surfaces [9,18,19], and improved surface biocompatibility [12,[20][21][22][23]. A large number of studies [2,10,20] have been directed toward this goal.…”

Section: Introductionmentioning

confidence: 99%

“…With the aim of improving the biocompatibility of biomaterials, surface modification with established materials has recently been extensively studied [2][3][4][5][6][7][8][9][10][11][12][13][14]. Self-assembled monolayer (SAM) interfaces have gained wide acceptance, so this surface modification method has experienced rapid progress.…”

Section: Introductionmentioning

confidence: 99%

The biocompatibility of self-assembled brush polymers bearing glycine derivatives

et al. 2010

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“…Hydrophobic, flexible lenses are most commonly used in surgery nowadays. Surface treatment of these commercial lenses to render them hydrophilic or even more hydrophobic is being investigated by several research groups as a method of improving their biocompatibility. This often involves either plasma or chemical treatment of lenses followed by treatment with modifying agents, and thus, involves elaborate post production processes.…”

Section: Introductionmentioning

confidence: 99%

Interpenetrating photopolymers for intraocular lens application

Shaik

Shailaja

Tammishetti

et al. 2016

J of Applied Polymer Sci

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Interpenetrating photopolymer network materials suitable for intraocular lens application are presented. A rapidly curable, transparent, hydrophobic material with appropriate optical and thermomechanical properties has been prepared from Benzyl acrylate and Benzyl methacrylate. To improve its biocompatibility and optimize surface-cell interactions, this material was modified with respect to its hydrophobicity. Materials which are more hydrophobic, and more hydrophilic, than the base resin were prepared by copolymerization with either a fluoroacrylate or a PEG acrylate respectively. All materials were characterized for their optical and thermomechanical properties. Their in-vitro cytotoxicity and interaction with mouse fibroblast cells were also studied. It was shown that all materials of the study were biocompatible and more hydrophilic materials resisted cell attachment and may be more suitable for IOL application than their more hydrophobic counter parts of the study. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44496.

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Influence of a new surface modification of intraocular lenses with fluoroalkylsilan on the adherence of endophthalmitis-causing bacteria in vitro

Abstract: The presented in vitro results indicate that Dynasilan surface modification is able to reduce the adherence of S. epidermidis and P. acnes on all IOL materials tested. Further studies regarding the stability of this modification and its biocompatibility must be performed.

Cited by 6 publications

References 20 publications

“Cell adhesion resistant, UV curable, polymer zinc oxide nanocomposite materials for intraocular lens application”

“Cell adhesion resistant, UV curable, polymer zinc oxide nanocomposite materials for intraocular lens application”

The biocompatibility of self-assembled brush polymers bearing glycine derivatives

Interpenetrating photopolymers for intraocular lens application

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