Influence of a cellulosic ether carrier on the structure of biphasic calcium phosphate ceramic particles in an injectable composite material

Dupraz, A.; Nguyen, T.P.; Richard, M.; Daculsi, G.; Passuti, N.

doi:10.1016/s0142-9612(98)00222-1

Cited by 92 publications

(62 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histological observation of the disintegration of BCP particles (also in composites) has been reported previously (Benahmed et al, 1996;Dupraz et al, 1998;Dupraz et al, 1999;Gauthier et al, 1999;Fellah et al, 2010). Dupraz et al developed a composite of BCP and a degradable cellulosic ether (Dupraz et al, 1998).…”

Section: Ac Van Leeuwen Et Alsupporting

confidence: 56%

Poly(trimethylene carbonate) and biphasic calcium phosphate composites for orbital floor reconstruction: a feasibility study in sheep

Leeuwen¹,

Yuan²,

Passanisi³

et al. 2014

eCM

View full text Add to dashboard Cite

In the treatment of orbital floor fractures, bone is ideally regenerated. The materials currently used for orbital floor reconstruction do not lead to the regeneration of bone. Our objective was to render polymeric materials based on poly(trimethylene carbonate) (PTMC) osteoinductive, and to evaluate their suitability for use in orbital floor reconstruction. For this purpose, osteoinductive biphasic calcium phosphate (BCP) particles were introduced into a polymeric PTMC matrix. Composite sheets containing 50 wt% BCP particles were prepared. Also laminates with poly(D,L-lactide) (PDLLA) were prepared by compression moulding PDLLA films onto the composite sheets. After sterilisation by gamma irradiation, the sheets were used to reconstruct surgically-created orbital floor defects in sheep. The bone inducing potential of the different implants was assessed upon intramuscular implantation.The performance of the implants in orbital floor reconstruction was assessed by cone beam computed tomography (CBCT). Histological evaluation revealed that in the orbital and intramuscular implantations of BCP containing specimens, bone formation could be seen after 3 and 9 months. Analysis of the CBCT scans showed that the composite PTMC sheets and the laminated composite sheets performed well in orbital floor reconstruction. It is concluded that PTMC/BCP composites and PTMC/BCP composites laminated with PDLLA have osteoinductive properties and seem suitable for use in orbital floor reconstruction.

show abstract

Section: Ac Van Leeuwen Et Alsupporting

confidence: 56%

Poly(trimethylene carbonate) and biphasic calcium phosphate composites for orbital floor reconstruction: a feasibility study in sheep

Leeuwen¹,

Yuan²,

Passanisi³

et al. 2014

eCM

View full text Add to dashboard Cite

show abstract

“…33 The absorption bands observed at 1045, 972, and 606 cm Ϫ1 correspond to a phosphate group while the shoulders at 553 and 1119 cm Ϫ1 were characteristic peaks of ␤-TCP. 34,35 The spectrum of CS-Gel HPN shows significant peaks at 1552 and 1655 cm…”

Section: Preliminary Biocompatibilitymentioning

confidence: 99%

Preparation and characterization of macroporous chitosan–gelatin/β‐tricalcium phosphate composite scaffolds for bone tissue engineering

Yin

Cui

et al. 2003

J Biomedical Materials Res

220

109

View full text Add to dashboard Cite

A biodegradable composite scaffold was developed using ␤-tricalcium phosphate (␤-TCP) with chitosan (CS) and gelatin (Gel) in the form of a hybrid polymer network (HPN) via co-crosslinking with glutaraldehyde. Various types of scaffolds were prepared by freezing and lyophilizing. These scaffolds were characterized by Fourier transform infrared, X-ray diffractometer, and scanning electron microscopy. The macroporous composite scaffolds exhibited different pore structures. Compressive properties were improved, especially compressive modulus from 3.9 -10.9 MPa. Biocompatibility was evaluated subcutaneously on rabbits. A mild inflammatory response was observed over 12 weeks. The results suggest that the scaffolds can be utilized in nonloading bone regeneration.

show abstract

“…A v ariety of injectable materials, both ceramic-and polymer-based, have been developed for use in multiple orthopaedic applications [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The combination of ceramic particles with polymeric matrices has also been extensiv ely inv estigated, in an attempt to mimic bone tissue, which may itself be seen as a complex composite material made of organic and inorganic components.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of ceramic particles with polymeric matrices has also been extensiv ely inv estigated, in an attempt to mimic bone tissue, which may itself be seen as a complex composite material made of organic and inorganic components. Different ceramic phases have been used, hydroxyapatite and tricalcium phosphate being the most common [4][5][6][7][8][9], as well as several polymeric matrices, both from synthetic [10][11][12][13][14] or natural origin, the latter including collagen, chitosan, gelatine and alginate, among others [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate-alginate microspheres as enzyme delivery matrices

2004

View full text Add to dashboard Cite

The present study concerns the preparation and initial characterisation of nov el calcium titanium phosphate-alginate (CTPalginate) and hydroxyapatite-alginate (HAp-alginate) microspheres, which are intended to be used as enzyme delivery matrices and bone regeneration templates. Microspheres were prepared using different concentrations of polymer solution (1% and 3% w/v) and different ceramic-to-polymer solution ratios (0.1, 0.2 and 0.4 w/w). Ceramic powders were characterised using X-ray diffraction, laser granulometry, Brunauer, Emmel and Teller (BET) method for the determination of surface area, zeta potential and Fourier transform infrared spectroscopy (FT-IR). Alginate was characterised using high performance size exclusion chromatography. The methodology followed in this investigation enabled the preparation of homogeneous microspheres with a uniform size. Studies on the immobilisation and release of the therapeutic enzyme glucocerebrosidase, employed in the treatment of Gaucher disease, were also performed. The enzyme was incorporated into the ceramic-alginate matrix before gel formation in two different ways: preadsorbed onto the ceramic particles or dispersed in the polymeric matrix. The two strategies resulted in distinct release profiles. Slow release was obtained after adsorption of the enzyme to the ceramic powders, prior to preparation of the microspheres. An initial fast release was achiev ed when the enzyme and the ceramic particles were dispersed in the alginate solution before producing the microspheres. The latter profile is very similar to that of alginate microspheres. The different patterns of enzyme release increase the range of possible applications of the system inv estigated in this work.

show abstract

Influence of a cellulosic ether carrier on the structure of biphasic calcium phosphate ceramic particles in an injectable composite material

Cited by 92 publications

References 0 publications

Poly(trimethylene carbonate) and biphasic calcium phosphate composites for orbital floor reconstruction: a feasibility study in sheep

Poly(trimethylene carbonate) and biphasic calcium phosphate composites for orbital floor reconstruction: a feasibility study in sheep

Preparation and characterization of macroporous chitosan–gelatin/β‐tricalcium phosphate composite scaffolds for bone tissue engineering

Calcium phosphate-alginate microspheres as enzyme delivery matrices

Contact Info

Product

Resources

About