Influence of a 5-year serial infection control and antibiotic stewardship intervention on cardiac surgical site infections

Frenette, Charles; Sperlea, David; Tesolin, Joey; Patterson, C. Richard; Thirion, Daniel J. G.

doi:10.1016/j.ajic.2016.02.029

Cited by 12 publications

(15 citation statements)

References 21 publications

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“…Many protocols have also been instituted for SSI; however, these have had mixed results. 17,18 This study further demonstrates the potential secondary complications after SSI.…”

Section: Discussionsupporting

confidence: 56%

Index complications predict secondary complications after infrainguinal lower extremity bypass for critical limb ischemia

Peacock

Shah

Farber

et al. 2017

Journal of Vascular Surgery

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“…Many protocols have also been instituted for SSI; however, these have had mixed results. 17,18 This study further demonstrates the potential secondary complications after SSI.…”

Section: Discussionsupporting

confidence: 56%

Index complications predict secondary complications after infrainguinal lower extremity bypass for critical limb ischemia

Peacock

Shah

Farber

et al. 2017

Journal of Vascular Surgery

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“…Four studies met the eligibility criteria of a cardiac surgery study population, included SSI as an outcome measurement, and used a bundled decolonization treatment strategy with intranasal mupirocin, chlorhexidine, and glycopeptide preoperative antibiotics. The relative risk of SSI for UD was estimated to be 0.35 (95% confidence interval [CI]: 0.26 to 0.46) [11,19]. This relative risk UD variable was derived from two studies that approximated our UD strategy whereby all patients were treated with mupirocin but only MRSA carriers were given vancomycin.…”

Section: Data Sourcesmentioning

confidence: 99%

Staphylococcus Aureus Prevention Strategies in Cardiac Surgery: A Cost-Effectiveness Analysis

Hong

Saraswat

Ellison

et al. 2018

The Annals of Thoracic Surgery

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“…The incidence of SSI in cardiac surgery is across a broad range. This complication is associated with an increase in the duration of hospitalization, mortality, and economic burden (Frenette et al, 2016;Gudbjartsson et al, 2016;Schimmer et al, 2017;Kachel et al, 2020;Liu et al, 2021). The incidence of readmission and mortality for SSI patients is about 46% and 1-14%, respectively, and the cost of treatment is 2.5 times higher than for non-SSI patients (Frenette et al, 2016;Gudbjartsson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery

Ding²,

Qin³

et al. 2023

Front. Cell. Infect. Microbiol.

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Background and aimsSurgical site infection is a common complication after surgery. Periprocedural antibiotics are necessary to prescribe for preventing or treating infections. The present study aimed to explore the effect of intravenous antibiotics on gut microbiota and menaquinone biosynthesis in patients, especially in elderly patients undergoing cardiac surgery.MethodsA total of 388 fecal samples were collected from 154 cardiac surgery patients. The V3–V4 hypervariable region of the bacterial 16S rRNA gene was amplified and sequenced on a MiSeq PE300. The gut microbiota diversity of samples was analyzed in terms of α- and β-diversity at the OTU level. The different groups were classified according to antibiotics in combinations and single antibiotics. PICRUSt2 was used for preliminary prediction of the gut microbiota function for menaquinone biosynthesis.ResultsThe intravenously administered antibiotics which are excreted via bile represents the main antibiotics that could disturb the gut microbiota’s composition in cardiac surgery patients, especially for elderly patients. The effect of antibiotics on gut microbiota is produced after antibiotics treatments over one week. The recovery of gut microbiota to the state of pre-antibiotics may require over two weeks of antibiotics withdrawal. Sex factor doesn’t represent as an influencer in gut microbiota composition. Long-term use of cefoperazone-sulbactam may affect coagulation function.ConclusionsThe composition of the gut microbiota had a significant change post-intravenous antibiotics treatment in cardiac surgery patients. The richness and diversity of gut microbiota are increased in elderly patients.

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Influence of a 5-year serial infection control and antibiotic stewardship intervention on cardiac surgical site infections

Cited by 12 publications

References 21 publications

Index complications predict secondary complications after infrainguinal lower extremity bypass for critical limb ischemia

Index complications predict secondary complications after infrainguinal lower extremity bypass for critical limb ischemia

Staphylococcus Aureus Prevention Strategies in Cardiac Surgery: A Cost-Effectiveness Analysis

Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery

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