Influence of 6% Hydroxyethyl Starch 130/0.4 Versus Crystalloid Solution on Structural Renal Damage Markers After Coronary Artery Bypass Grafting: A Post Hoc Subgroup Analysis of a Prospective Trial

Datzmann, Thomas; Hoenicka, Markus; Reinelt, Helmut; Liebold, Andreas; Gorki, Hagen

doi:10.1053/j.jvca.2017.05.041

Cited by 16 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…174 Two small trials further confirmed the lack of renal injury from HES. 175,176 A retrospective cohort study found a lower dose of HES was significantly associated with a reduced incidence of acute renal injury and recommended that the cumulative dose of modern HES in cardiac surgery should be kept less than 30 mL/kg. 177 MASSIVE TRANSFUSION.…”

Section: Iia Level Of Evidence A)mentioning

confidence: 99%

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

Tibi

McClure

Huang

et al. 2021

The Annals of Thoracic Surgery

126

View full text Add to dashboard Cite

O wing to the constantly evolving nature of the medical literature, The Society of Thoracic Surgeons (STS) clinical practice guidelines periodically undergo evaluation and updating. A multidisciplinary panel of experts was convened by STS, which includes members of the Society of Cardiovascular Anesthesiologists (SCA), the American Society of ExtraCorporeal Technology (AmSECT), and the Society for the Advancement of Blood Management (SABM), to review the latest data on patient blood management and to update the 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines.

show abstract

Section: Iia Level Of Evidence A)mentioning

confidence: 99%

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

Tibi

McClure

Huang

et al. 2021

The Annals of Thoracic Surgery

126

View full text Add to dashboard Cite

show abstract

Section: Fluid Managementmentioning

confidence: 99%

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

Tibi

McClure

Huang

et al. 2021

Journal of Cardiothoracic and Vascular Anesthesia

131

View full text Add to dashboard Cite

“…Among various studies, the volume regimens, HES dosages, investigated parameters, and observation periods differed. 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

“…One possible mechanism of damage is the increased colloid osmotic pressure, described in an experimental animal model. 8 , 10 – 12 …”

Section: Introductionmentioning

confidence: 99%

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Güneş

Süngü

Kılıçarslan

et al. 2018

DDDT

View full text Add to dashboard Cite

ObjectiveThis study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch (Voluven) on the kidney tissue of rats with late renal failure due to ureteral obstruction.Materials and methodsRats were divided into four groups: Group C, control; Group HES, hydroxyethyl starch solution (HES) 130/0.4 (Voluven®); Group UUO, unilateral ureteral obstruction (UUO); and Group UUO-HES, UUO-HES 130/0.4 (Voluven®). In the groups with ureteral obstruction, the distal part of the right ureter was accessed and sutured through a lower abdominal incision under ketamine anesthesia. Any signs of late-stage renal failure were evaluated after three weeks. Rats in the HES group and the renal failure-HES group were administered with HES 130/0.4 as a single intravenous dose of 20 mL/kg. After a follow-up of 24 hours, intra-abdominal blood sample was collected, and the rats were sacrificed. Biochemical and histopathological parameters were then evaluated.ResultsUreteral obstruction significantly increased urea and creatinine levels. In addition, when the UUO-HES and HES groups were compared, the administration of HES increased urea and creatinine levels in the UUO-HES group. Nitric oxide enzyme activity and malondialdehyde levels have significantly increased in the UUO groups. In addition, HES significantly increased nitric oxide activity and malondialdehyde levels in the UUO-HES group, in comparison with the HES group. The activity of caspases 3 and 8 was significantly increased in the UUO groups. In addition, HES significantly increased the activity of caspases 3 and 8 in the UUO-HES group, in comparison with the HES group. Light microscopy revealed significant changes in the UUO groups, especially in the obstructed kidneys.ConclusionIf indicated, HES should be used with caution in cases of UUO, but not in the cases of bilateral ureteral obstruction. Other aspects of these findings, including the clinical significance and practical applications, merit further experimental and clinical investigation.

show abstract

Influence of 6% Hydroxyethyl Starch 130/0.4 Versus Crystalloid Solution on Structural Renal Damage Markers After Coronary Artery Bypass Grafting: A Post Hoc Subgroup Analysis of a Prospective Trial

Cited by 16 publications

References 37 publications

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Contact Info

Product

Resources

About