Influence factors of extra-articular manifestations in rheumatoid arthritis

Abstract

Background and objectiveExtra-articular manifestations (EAMs) are serious outcomes or complications of rheumatoid arthritis (RA) with increasing mortality and morbidity. The purpose was to explore the factors influencing EAMs, tissue-specific/systemic EAMs, and the concurrence of several EAMs.Patients and methodsIn total, 519 inpatients with RA were enrolled. The clinical characteristics, laboratory parameters, and medications of RA patients and the details of EAMs were recorded carefully. Differences between groups were examined by a Chi-square test, independent samples t test, one-way analysis of variance, Mann–Whitney U test, and Kruskal–Wallis H test. Binary and ordinal logistic regression analyses were performed to determine the relationship between influential factors and EAMs, tissue-specific/systemic EAMs, and the concurrence of several EAMs.ResultsThe morbidity of EAMs was 44.70%. Male sex, age, and traditional Chinese medicine (TCM) were independent influential factors of EAMs, and a number of statistically significant influence factors were found in the multivariate analysis of tissue-specific/systemic EAMs. Finally, age, CRP levels, number of RA-affected types of joints, and TCM were the factors that independently influenced the concurrence of several EAMs.ConclusionInfluential factors identified in this study could be recommended in clinical work, which is hopeful to decrease the morbidity and mortality of EAMs in RA.

Traditional Chinese Medicine Compound Preparations Are Associated with Low Disease-Related Complication Rates in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study of 11,074 Patients

“…Consistent with our results, these classic complications increased the risk of recurrence of RA inflammation [41], potentially contributing to increased readmission of RA patients. Advanced age and hypertension were shown to be significantly associated with the extraarticular manifestations of RA [42,43], which is consistent with our findings. An analysis based on British electronic medical records showed that the incidence of joint replacement increased with age [12].…”

Treating Rheumatoid Arthritis by Genetically Engineered Biological Drugs: A Case Study.

“…21,22,24,29 Scientists prove the RA patients' complication developments. 7,9,14,15,27 In the conditions of a prolonged inflammatory process and ineffective pharmacological therapy, the patient developed secondary amyloidosis. The other specialists from abroad also underlines the secondary amyloidosis-forming while the prolonged inflammatory process.…”

“…The other specialists from abroad also underlines the secondary amyloidosis-forming while the prolonged inflammatory process. [14][15][16][17][18][19] However, against the background of adequate therapy, the activity of the inflammatory process decreased. During the repeated diagnostic biopsy of the rectum, we found out amyloid elements.…”

“…The incidence of amyloidosis in RA patients varies from 11% to 29%, depending on the population and diagnostic strategy. [13][14][15][16] It is necessary to screen for amyloidosis in systemic connective tissue diseases. In amyloidosis dynamics, there are latent (hidden); proteinuric, nephrotic and azotemic stages.…”

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

“…In addition, patients with strongly positive ACPAs and RF positivity in the absence of joint symptoms may have significant extra-articular involvement, including recurrent scleritis, pleuropericarditis, or interstitial lung disease ( 53 ). Moreover, high levels of ACPAs are associated with greater susceptibility to ocular diseases ( 54 ).…”