Influence du syndrome des ovaires polykystiques sur la qualité ovocytaire et embryonnaire

Sermondade, Nathalie; Dupont, Charlotte; Massart, Pascal; Cédrin‐Durnerin, Isabelle; Levy, Ronaldo; Sifer, C.

doi:10.1016/j.gyobfe.2012.11.003

Cited by 9 publications

(3 citation statements)

References 47 publications

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“…Furthermore, the criteria used to diagnose PCOM were extremely heterogeneous because of a lack of consensus. The results provided by these studies are thus conflicting, finding either a better oocyte/embryo quality and pregnancy rate or vice versa (18). Moreover, in most of these studies, the oocyte quality evaluation was only based on the evaluation of the nuclear stage (i.e., the mean number of metaphase II [MII] oocytes) (12,14,16).…”

mentioning

confidence: 99%

Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Sigala

Sifer

Dewailly

et al. 2015

Fertility and Sterility

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mentioning

confidence: 99%

Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Sigala

Sifer

Dewailly

et al. 2015

Fertility and Sterility

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“…In our study, while samples coming from endometriosis patients presented calcium-signaling upregulated, the PCOS samples showed it downregulated. In spite of most of publication find similar clinical outcomes after IVF in PCOS patients, it is related to alterations in oocyte quality and consequently in embryo quality, may be due to endocrine and intra-ovarian environment (Sermondade et al ., 2013). The calcium metabolism downregulated in the PCOS embryos might reflect the poorer oocyte quality observed in those patients.…”

Section: Discussionmentioning

confidence: 99%

Expressed proteins and activated pathways in conditioned embryo culture media from IVF patients are diverse according to infertility factors

Bonetti

Haddad

Domingues

et al. 2019

JBRA Assisted Reproduction

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Objective:Given that the embryo culture medium secretome reflects the embryo development, we hypothesize that protein profiles are affected according to infertility factors, which can be responsible for detrimental embryonic developmental competence. The aim of this study was to screen the protein profile of conditioned embryo culture media in patients presenting deep infiltrating endometriosis (ENDO) and polycystic ovarian syndrome (PCOS) undergoing IVF, by proteomics approaches. The control group was constituted by tubal factor patients.Methods:Patients underwent in vitro fertilization (IVF) treatment as routine and oocytes were fertilized by ICSI. The embryos were group cultured until day 3 of development, and after transfer the culture media were collected. For the proteomics analysis, two pools of samples were prepared for groups CONTROL and PCOS, and 4 pools of samples for group DIE. Samples were prepared to deplete high abundant proteins and followed evaluated by high throughput proteomics approach.Results:The embryonic organ and tissue development were physiological functions activated, based on proteins identified in the 3 study groups of samples. The samples coming from DIE patients presented a high calcium activity and on the other hand, embryos coming from PCOS patients showed a decreased calcium action. Other pathways as grow factors through the EGF signaling pathway overexpressed in ENDO culture medium and protein kinase A in PCOS were also observed.Conclusions:Proteomic embryonic secretome will advance our knowledge of early embryogenesis and additionally could lead to improved selection of embryos for transfer warrants further investigation.

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“…Differential expression of genes in oocytes from PCOS women indicative of defects in meiosis or early embryonic development (Wood, et al 2007) provide further support for this premise. Additionally, fertilization rates in PCOS women in IVF settings have yielded variable results ranging from no effect to higher rates of fertilization (Sermondade, et al 2013). While the pregnancy rates among PCOS women undergoing IVF have been found to be similar to the non-PCOS women undergoing IVF (Heijnen, et al 2006), various meta-analysis have shown that infants born to women with PCOS are at higher risk for preterm birth, low birth weight, perinatal mortality, congenital abnormalities, and likelihood of birth by Caesarean section, (Boomsma et al 2006; Qin et al 2013).…”

Section: Mediators Of Pcosmentioning

confidence: 99%

Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome

Puttabyatappa

Padmanabhan

2018

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting women of reproductive age. The origin of PCOS is still not clear and appears to be a function of gene x environment interactions. This review addresses the current knowledge of the genetic and developmental contributions to the etiology of PCOS, the ovarian and extra-ovarian mediators of PCOS and the gaps and key challenges that need to be addressed in the diagnosis, treatment and prevention of PCOS.

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Influence du syndrome des ovaires polykystiques sur la qualité ovocytaire et embryonnaire

Cited by 9 publications

References 47 publications

Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study

Expressed proteins and activated pathways in conditioned embryo culture media from IVF patients are diverse according to infertility factors

Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome

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