Influence des comorbidités sur l´évolution et le pronostic des patients porteurs de broncho-pneumopathie chronique obstructive dans un centre tunisien

Saad, A. Ben; Loued, L.; Joobeur, S.; Migaou, A.; Mhamed, S. Cheikh; Rouatbi, N.; Fahem, N.

doi:10.11604/pamj.2020.36.76.21511

Cited by 1 publication

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An observational study of the valuation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) concluded that the prevalence of comorbidities is higher in COPD patients, reaching up to 38%, compared to smokers with normal lung function and non-smokers [ 35 ]. In addition, a recent study conducted on COPD patients in a Tunisian Hospital established that comorbidities in COPD patients result in poorer prognosis and higher severity of symptoms [ 36 ].…”

Section: Reviewmentioning

confidence: 99%

“…However, many confounding factors also play a role in the pathophysiology of anemia in COPD patients like cardiovascular disorders, old age, malnutrition, occult blood loss, drugs such as angiotensin-converting enzyme inhibitors or theophylline, endocrine abnormality, and oxygen therapy [36,[44][45][46]. Therefore, screening for other types of anemias, such as iron, folate, or vitamin B12 deficiency, is also necessary for COPD patients [36,45].…”

Section: Copd and Anemiamentioning

confidence: 99%

See 1 more Smart Citation

Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices

Tariq¹,

Ismail²,

Thapa³

et al. 2023

Cureus

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) constitutes a set of heterogeneous symptoms affecting millions of people worldwide. The associated comorbidities developing in COPD involve dysregulation in physiological pathways resulting from systemic inflammation in respiratory airways. In addition to mentioning the pathophysiology, stages, and consequences of COPD, this paper also defines red blood cell (RBC) indices such as hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, red blood cell distribution width, and RBC count. It explains the role of RBC indices and RBC structural abnormalities with disease severity and exacerbations in COPD patients. Although many factors have been studied as a marker of morbidity and mortality for COPD patients, RBC indices have emerged as revolutionary evidence. Therefore, the effectiveness of evaluating RBC indices in COPD patients and their importance as a negative predictor of survival, mortality, and clinical outcomes have been debated through rigorous literature reviews. Furthermore, the prevalence, mechanisms of development, and prognosis of underlying anemia and polycythemia in COPD have also been evaluated, with anemia most significantly associated with COPD. Therefore, more studies should be conducted to address underlying anemia in COPD patients to lessen the severity and disease burden. Correcting the RBC indices in COPD patients remarkably impacts the quality of life and reduces in-patient admissions, healthcare resource utilization, and costs. Hence, it is noteworthy to understand the significance of considering RBC indices while dealing with COPD patients.

show abstract

Section: Reviewmentioning

confidence: 99%