Influence analysis of glycerol in fumaric acid co-fermentation process by Rhizopus arrhizus

Liu, Huan; Xiao, Qi; Yu, Yue; Zhang, Yakun; Deng, Li; Wang, Fang

doi:10.1016/j.jece.2020.104750

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…The ratio of saturated and unsaturated fatty acids directly determines the permeability of the membrane. Glycerol has been proven to increase saturated fatty acids of cell membrane 36 . Fatty acid saturation determines the overall stability of the membrane to some extent, while an increase in fatty acid saturation can cause a decrease in membrane fluidity and thus its permeability 37 , and it blocks the secretion of ergosterol, the precursor of EP, and promotes the synthesis of EP.…”

Section: Resultsmentioning

confidence: 99%

Optimization of the nutritional constituents for ergosterol peroxide production by Paecilomyces cicadae based on the uniform design and mathematical model

Fenhui

Qian

et al. 2022

Sci Rep

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Abstractwe optimized medium components for the production of ergosterol peroxide (EP) by Paecilomyces cicadae based on a mono-factor experiment, a uniform design, and a non-linear regression analysis. The maximum EP yield achieved was 256 μg/L, which was increased by 5 folds compared with that before the optimization. Structured Monod model, Andrews model, Contois model, and Aibe model were developed to describe the effects of viscosity inhibition, substrate, and production on biomass growth. The results showed that the Monod model could predict biomass growth, and the effects of viscosity and substrate on the EP concentration were significantly higher compared with the effect of production. The addition of water and glycerol could decrease the viscosity inhibition and glycerol inhibition, and further increase the EP yield. The newly developed structured model was demonstrated for batch growth of P.cicadae.

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Section: Resultsmentioning

confidence: 99%

Optimization of the nutritional constituents for ergosterol peroxide production by Paecilomyces cicadae based on the uniform design and mathematical model

Fenhui

Qian

et al. 2022

Sci Rep

View full text Add to dashboard Cite

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Recent Advances on the Production of Itaconic Acid via the Fermentation and Metabolic Engineering

et al. 2023

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Itaconic acid (ITA) is one of the top 12 platform chemicals. The global ITA market is expanding due to the rising demand for bio-based unsaturated polyester resin and its non-toxic qualities. Although bioconversion using microbes is the main approach in the current industrial production of ITA, ecological production of bio-based ITA faces several issues due to: low production efficiency, the difficulty to employ inexpensive raw materials, and high manufacturing costs. As metabolic engineering advances, the engineering of microorganisms offers a novel strategy for the promotion of ITA bio-production. In this review, the most recent developments in the production of ITA through fermentation and metabolic engineering are compiled from a variety of perspectives, including the identification of the ITA synthesis pathway, the metabolic engineering of natural ITA producers, the design and construction of the ITA synthesis pathway in model chassis, and the creation, as well as application, of new metabolic engineering strategies in ITA production. The challenges encountered in the bio-production of ITA in microbial cell factories are discussed, and some suggestions for future study are also proposed, which it is hoped offers insightful views to promote the cost-efficient and sustainable industrial production of ITA.

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Influence analysis of glycerol in fumaric acid co-fermentation process by Rhizopus arrhizus

Cited by 2 publications

References 28 publications

Optimization of the nutritional constituents for ergosterol peroxide production by Paecilomyces cicadae based on the uniform design and mathematical model

Optimization of the nutritional constituents for ergosterol peroxide production by Paecilomyces cicadae based on the uniform design and mathematical model

Recent Advances on the Production of Itaconic Acid via the Fermentation and Metabolic Engineering

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