Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease

Domingo, Alberto; Cano-Martínez, D.; Lobo, M.V. Toledo; Fernández‐Moreno, María Dolores; Hernández-Breijo, Borja; Sacristán, Silvia; Sanmartín-Salinas, Patricia; Monserrat, Jorge; Gisbert, Javier P.; Guijarro, Luis

doi:10.1080/1354750x.2016.1252950

Cited by 23 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in a study of 47 IBD patients in various stages of disease (e.g. active vs. remission), it was reported that colonic Iba-1 expression was higher in the patients with active disease 33 . There are reports that Iba-1 expression was increased following addition of the pro-inflammatory cytokines IL-1β and TNF-α in a rat macrophage cell line as well as in mice with bleomycin-induced acute lung injury 34,35 .…”

Section: Discussionmentioning

confidence: 99%

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice

Martin

Blomquist

Henare

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Detection of cytoplasmic DNA by the host’s innate immune system is essential for microbial and endogenous pathogen recognition. In mammalian cells, an important sensor is the stimulator of interferon genes (STING) protein, which upon activation by bacterially-derived cyclic dinucleotides (cDNs) or cytosolic dsDNA (dsDNA), triggers type I interferons and pro-inflammatory cytokine production. Given the abundance of bacterially-derived cDNs in the gut, we determined whether STING deletion, or stimulation, acts to modulate the severity of intestinal inflammation in the dextran sodium sulphate (DSS) model of colitis. DSS was administered to Tmem173gt (STING-mutant) mice and to wild-type mice co-treated with DSS and a STING agonist. Colitis severity was markedly reduced in the DSS-treated Tmem173gt mice and greatly exacerbated in wild-type mice co-treated with the STING agonist. STING expression levels were also assessed in colonic tissues, murine bone marrow derived macrophages (BMDMs), and human THP-1 cells. M1 and M2 polarized THP-1 and murine BMDMs were also stimulated with STING agonists and ligands to assess their responses. STING expression was increased in both murine and human M1 polarized macrophages and a STING agonist repolarized M2 macrophages towards an M1-like subtype. Our results suggest that STING is involved in the host’s response to acutely-induced colitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice

Martin

Blomquist

Henare

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…A limitation of the present study is that the potential serum biomarkers (MARCKS, SPINT2, and APOB) of NTDs in the rats were not examined in human maternal serum. Given that there are genetic and environmental differences between animal models and human diseases, while many biomarkers found in animal models have been further confirmed in patients with a variety of different diseases including neurodegenerative, cancer, and inflammatory diseases [36][37][38][39], there are also a few reports that animal biomarkers are not or partly consistent with those in patients [40,41]. Thus, in the future it is necessary to Fig.…”

Section: Discussionmentioning

confidence: 99%

CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects

et al. 2017

View full text Add to dashboard Cite

The protein composition of cerebrospinal fluid (CSF) in neural tube defects (NTDs) remains unknown. We investigated the protein composition of CSF from 9 infants with NTDs using isobaric tags for relative and absolute quantitation (iTRAQ). We identified 568 proteins in the CSF of infants with spina bifida, which is the most common type of NTD. Among these, 18 proteins were associated with neural tube closure in the CSF during human embryonic neurulation and 5 were involved in NTDs. Based on these results, an animal model was further utilized to investigate early serum biomarkers for NTDs. We found that the myristoylated alanine-rich C-kinase substrate, Kunitz-type protease inhibitor 2, and apolipoprotein B-100 protein levels were decreased in both embryos and the sera of pregnant Sprague-Dawley rats carrying embryos with NTDs. CSF proteins may be useful in the discovery of potential serum biomarkers for NTDs.

show abstract

“…Although the mechanism of rs2857595 gene polymorphism and susceptibility to oral cancer has not been reported, there is a linkage disequilibrium between rs2857595 locus and multiple inflammatory genes (Wei et al, 2014). In addition, a recent animal study found that AIF-1 protein as a biomarker for intestinal mucosal barrier repair can promote intestinal mucosal damage healing by reducing the intestinal mucosal inflammatory response and increasing the differentiation of intestinal mucosal cells (Roman et al, 2017). Although this study only explored the relationship between AIF-1 and intestinal mucosal injury repair, the results suggest that the relationship between AIF-1 gene and oral cancer may be related to the healing of oral mucosal injury, but the specific mechanism remains to be further studied.…”

Section: Discussionmentioning

confidence: 99%

Association of snps of aif-1 gene with susceptibility to oral cancer in chinese population

Zhang

Deng

2021

Food Sci. Technol

View full text Add to dashboard Cite

Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease

Abstract: These findings support AIF-1 as a new biomarker of mucosal healing in experimental colitis and suggest that p38 activation is involved in the mucosal healing intracellular mechanism induced by IFX treatment.

Cited by 23 publications

References 46 publications

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice

CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects

Association of snps of aif-1 gene with susceptibility to oral cancer in chinese population

Contact Info

Product

Resources

About