Infliximab in Steroid-Dependent Ulcerative Colitis

Armuzzi, Alessandro; Pugliese, Daniela; Marzo, Manuela; Felice, Carla; Andrisani, Gianluca; Vitale, Giovanna; Mocci, Giammarco; Vitis, I. De; Papa, Alfredo; Rapaccini, Gian Ludovico; Guidi, Luisa

doi:10.1016/s0016-5085(11)62449-9

Cited by 13 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] All 20 studies reported a mean age. The composite mean age was 39.2 years with a mean range of 36.2 to 44 years.…”

Section: Biological Agentsmentioning

confidence: 99%

“…Based on the age range data alone, 2 studies did not include elderly patients. 20,26 There were a total of 14 studies in which the estimated number of elderly patients could be calculated by adding 1 or 2 SD to the mean age, whichever provided the closest estimate to an elderly age. Using this method, approximately 16% of the study population had a mean age of 53.4 years (mean of 'mean plus 1 SD') or older.…”

Section: Biological Agentsmentioning

confidence: 99%

“…28 A 2004 study by Ochsenkuh showed IFX to be as effective as corticosteroids in the induction of remission; 26 a similar study by Armuzzi corroborated these results. 20 In the ACT-1 and ACT-2 trials completed by Rutgeerts et al, 121 patients in each of the two studies received IFX 5 mg/kg. 30 In comparison to placebo, remission induction rates for IFX were 38.8% and 33.9% versus 14.9% and 5.7% respectively.…”

mentioning

confidence: 99%

“…Two studies did not include elderly patients based on the reported age ranges. 20,26 The ACT-1 and ACT-2 trials reported mean age with SD. 30 In the ACT-1 trial the mean age was 42.4 and the mean age plus 1 and 2 SD was 56.7 and 71.0, respectively.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Baggenstos

Hanson²,

Shaukat

2013

Clinical Medicine Insights: Geriatrics

View full text Add to dashboard Cite

Ulcerative colitis (UC) is increasingly recognized as a disease affecting the elderly. Approximately 10%-30% of the UC population is over the age of 60 years. Additionally, younger patients with UC are aging and thus comprise a second group of elderly IBD patients. To date, there have been no clinical trials that have evaluated treatment efficacy of UC in the elderly population. The aim of our study was to conduct a systematic review of all randomized controlled trials (RCTs) addressing treatment outcome in UC; we also sought to identify the elderly population, defined as age 60 years or older, represented in these studies, to see if pooled data would lead to meaningful conclusions regarding treatment efficacy and safety profile in the elderly. A search of the MEDLINE database via PubMed and the EMBASE database via Scopus was performed to identify all RCTs evaluating medical therapy for UC in humans, published within the English language through September 2012. Studies were grouped into three categories: biological agent (BA) therapy; immunosuppressant (IS) therapy; and 5-aminosalicylic acid (5-ASA) therapy. To estimate the number of elderly patients in each study, mean age plus 1 and 2 standard deviations (SD) was calculated to find the closest approximation to age 60. Of 876 studies, 112 RCTs were included in the final analysis-20 studies for BA, 20 for IS, and 72 for 5-ASA agents. While nearly all studies reported either a mean or median age, only 38% additionally reported the SD and age range. The mean composite age was 39.2 years for the BA studies, 38.5 years for the IS studies, and 42.8 years for the 5-ASA studies, consistent with a young middle-aged patient. We estimated that no more than 16% of patients per study would have qualified as elderly, and in most cases a much smaller percentage (,8%). Additionally, there were no BA or IS RCTs that reported results by age subgroup analysis. Four studies in the 5-ASA group report age-specific analyses and showed no difference in treatment efficacy by age. None of the 112 RCTs reported age sub-analyses of safety, tolerability, adverse events, or withdrawal rates. There is insufficient evidence to evaluate efficacy of treatment and adverse events from treatment for UC in the elderly. With the rising number of elderly patients with UC, there is a need for more clinical trials that specifically address UC treatment in this unique population.

show abstract

Section: Biological Agentsmentioning

confidence: 99%

Section: Biological Agentsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Baggenstos

Hanson²,

Shaukat

2013

Clinical Medicine Insights: Geriatrics

View full text Add to dashboard Cite

show abstract

“…С развитием технологии синтеза моноклональных антител стало возможным применение инфликсимаба (ИНФ) -антител к α-фактору некроза опухоли, эффек-тивность которого при ЯК продемонстрирована в ходе рандомизированных контролируемых испытаний [15][16][17] и подтверждена данными Кокрановского системати-ческого обзора [18]. Однако если в целом ИНФ в сочета-нии со стандартной терапией при ЯК позволяет избежать хирургического лечения почти у 90% пациентов в течение 1 года [19], то при ТО ЯК, резистентной к внутривенным ГКС, к хирургическому лечению, несмотря на введения ИНФ, приходится прибегать практически в 1 / 3 случаев [20][21][22].…”

unclassified

Long-term results of medical treatment in patients with a severe attack of ulcerative colitis

et al. 2015

Ter. arkh.

View full text Add to dashboard Cite

Print quality evaluation and applied colour management in coldset offset newspaper print

Nussbaum¹,

Hardeberg²

2011

Color Research & Application

View full text Add to dashboard Cite

This article aims to investigate print quality in newspaper print, by considering the appropriate calibration standard and applying colour management. In particular, this article examines the colorimetric properties of eight Norwegian newspaper printing presses, to evaluate the relevant colour separation approach, either by applying custom separation profiles or by using an industry standard profile. The key method underlying the work described here relies on obtaining colour measurements to determine the repeatability of each participant in terms of colour differences. Furthermore, the variation between the eight newspaper printing presses and the variation according to the colorimetric values of the ISO 12647‐3 standard are important parts of the quantitative evaluation. Based on the colour measurements two custom ICC profiles were generated and an industry standard profile “ISOnewspaper26v4.icc” was also used. The first custom profile was generated using averaged colour measurement data set from a test print run, and the second using a data set averaged between measured data and the characterization data set “IFRA26.txt” provided by IFRA. These three profiles were applied to four test images, which were then printed by the eight newspaper printing presses. A psychophysical experiment was carried out to determine the “pleasantness” of the reproductions, which were produced using the three profiles. The results of the study show the performance of the appropriate profile, which is applied to the eight newspaper printing presses to obtain significant best print quality. Eventually the results demonstrate the fact that the print variations in colours between the eight printing presses are larger thanthe difference between the custom and the standard profiles. Hence, the print variations and not the profile selection may have determined the visual print quality. Therefore the study reveals the importance of adopting international standards and methods instead of using insufficiently defined house standards to preserve equal results among different newspaper printing presses. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2011

show abstract

Infliximab in Steroid-Dependent Ulcerative Colitis

Cited by 13 publications

References 0 publications

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Long-term results of medical treatment in patients with a severe attack of ulcerative colitis

Print quality evaluation and applied colour management in coldset offset newspaper print

Contact Info

Product

Resources

About