Infliximab/Anti‐TNF

Vardanyan, Marina; Parkin, Edward C.; Rilo, Horacio

doi:10.1002/9781444355628.ch26

Cited by 1 publication

(1 citation statement)

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“…Pancreatic islet transplantation has been developed to address the need for minimally invasive pancreatic implantation. The approach utilizes purified allogeneic donor islets which are infused percutaneously into the recipient's liver via the portal vein 196,197 . However, the high glucose, low oxygen, and increased toxin levels in the liver are suboptimal for the integration of fragile pancreatic islets 198 .…”

Section: The Pancreasmentioning

confidence: 99%

Solid Organ Bioprinting: Strategies to Achieve Organ Function

2020

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The field of tissue engineering has advanced over the last decade, but the largest impact on human health should be achieved with the transition of engineered solid organs to the clinic. The number of patients suffering from solid organ disease continues to increase, with over 100,000 patients on the US national waitlist and approximately 730,000 deaths in the United States resulting from end-stage organ disease annually. While flat, tubular, and hollow non-tubular engineered organs have already been implanted in patients, in vitro formation of a fully functional solid organ at a translatable scale has not yet been achieved. Thus, one major goal is to bioengineer complex, solid organs for transplantation, composed of patient-specific cells. Among the myriad of approaches attempted to engineer solid organs, 3D bioprinting offers unmatched potential. This review highlights the structural complexity which must be engineered at nano-, micro-, and mesostructural scales to enable organ function. We showcase key advances in bioprinting solid organs with complex vascular networks and functioning microstructures, advances in biomaterials science that have enabled this progress, the regulatory hurdles the field has yet to overcome, and cutting edge technologies that bring us closer to the promise of engineered solid organs.

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Section: The Pancreasmentioning

confidence: 99%