Inflection points of cardiovascular responses and oxygenation are correlated in the distal but not the proximal portions of muscle during incremental exercise

Mizuno, Masaki; Tokizawa, Ken; Ishii, Takashi; Muraoka, Isao

doi:10.1152/japplphysiol.00213.2004

Cited by 18 publications

(38 citation statements)

References 32 publications

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“…Since perfusion and _ VO 2 within a muscle are heterogeneous during exercise (Kalliokoski et al 2001;Laaksonen et al 2003;Richardson et al 2001), the _ VO 2 / _ QO 2 ratio is not expected to be uniformly distributed in the muscle. Studies describing oxygenation differences in the same muscle during human exercise are in accordance with this hypothesis (Kennedy et al 2006;Kime et al 2005;Miura et al 2001Miura et al , 2004Mizuno et al 2004Mizuno et al , 2006Quaresima et al 2001).…”

Section: Introductionsupporting

confidence: 68%

Heterogeneity of muscle deoxygenation kinetics during two bouts of repeated heavy exercises

Prieur

Berthoin²,

Marles³

et al. 2010

Eur J Appl Physiol

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This study examines the effect of prior heavy exercise on the spatial distribution of muscle deoxygenation kinetics at the onset of heavy-intensity cycling exercise. Young untrained male adults (n = 16) performed two consecutive bouts of 6 min of high intensity cycle exercise separated by 6 min at 35 W. Muscle deoxygenation (HHb) was monitored continuously by near-infrared spectroscopy at eight sites in the quadriceps. Prior heavy exercise reduced the delay before the increase in HHb (9 +/- 2 vs. 5 +/- 2 s; P < 0.001). The standard deviation of TD HHb of the eight sites was decreased by the performance of prior exercise (1.1 +/- 0.5 vs. 0.8 +/- 0.4 s; P < 0.05). The transient decrease in HHb during the first 10 s of exercise was less during the second bout than during the first bout (0.6 +/- 0.6 vs. 0.3 +/- 0.3 A.U.; P < 0.01). The standard deviation of this decrease was also reduced by prior exercise (0.5 +/- 0.3 vs. 0.3 +/- 0.2 A.U.; P < 0.01). Lastly, prior exercise decreased significantly the standard deviation of the HHb rise during the time period corresponding to the pulmonary VO(2) slow component. These results indicate that prior heavy exercise reduced the spatial heterogeneity of muscle deoxygenation kinetics at the early onset of heavy exercise and during the development of the pulmonary VO(2) slow component. It indicates that the distribution of the VO(2)/O(2) delivery ratio within muscle was improved by the performance of a prior exercise.

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Section: Introductionsupporting

confidence: 68%

Heterogeneity of muscle deoxygenation kinetics during two bouts of repeated heavy exercises

Prieur

Berthoin²,

Marles³

et al. 2010

Eur J Appl Physiol

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“…A number of studies have confirmed regional differences in muscle oxygenation and blood volume patterns (derived with near infrared spectroscopy) within a particular muscle during exercise (Esaki et al, 2005;Kennedy et al, 2006;Miura, McCully, Nioka, & Chance, 2004;Mizuno, Tokizawa, Iwakawa, & Muraoka, 2004;Quaresima, Colier, van der Sluijs, & Ferrari, 2001;Quaresima, Ferrari, Franceschini, Hoimes, & Fantini, 2004;Torricelli et al, 2004). In general, the magnitudes of responses in these parameters differ considerably intramuscularly, with greater changes associated with the distal than the proximal muscle region.…”

Section: Introductionmentioning

confidence: 88%

“…In general, the magnitudes of responses in these parameters differ considerably intramuscularly, with greater changes associated with the distal than the proximal muscle region. Recent data suggest that such regional differences may depend on exercise mode (Kennedy et al, 2006) and may be enhanced with exercise intensity (Kennedy et al, 2006;Mizuno et al, 2004). Differences in local blood supply due to differences in intramuscular pressures and divergence of the muscular activity within the muscle are two physiological factors that have been suggested to explain regional differences in oxygenation and blood volume (cf.…”

Section: Introductionmentioning

confidence: 99%

Oxygenation and EMG in the proximal and distal vastus lateralis during submaximal isometric knee extension

Crenshaw

Bronée

Krag

et al. 2010

Journal of Sports Sciences

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Muscle oxygenation responses are reportedly greater in the distal muscle region than in the proximal muscle region. We combined near infrared spectroscopy and electromyography (EMG) to determine whether regional differences in oxygenation are associated with differences in (1) muscle activation and/or (2) fatigue development. Nine males performed 2-min sustained isometric knee extensions at 15% and 30% maximum voluntary contraction during which oxygenation and EMG were recorded simultaneously from proximal and distal locations of the vastus lateralis muscle. Near infrared spectroscopy variables for oxygen saturation (StO(2)%) were initial slope at contraction onset, peak drop, and recovery slope at contraction end. Electromyography produced the root mean square to indicate muscle activation and mean power frequency changes over time (decreasing slope) to indicate fatigue development. For StO(2)%, significantly greater peak drop and steeper recovery slope were found for the distal muscle region than for the proximal muscle region. Root mean square, however, was not different between locations. Mean power frequency decreased throughout the contractions but changes were not different between locations. Our results indicate that for modest submaximal contractions, regional differences in oxygenation are not associated with differences in muscle activation or with fatigue development (as interpreted by changes in mean power frequency over time).

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“…We chose to attach the NIRS-probe to the distal portion of the M. Vastus Lateralis, assuming that this would provide a good representation of the exercising muscle. However, recent studies have reported local differences in NIRSsignal between the distal and the proximal portions of the M. Vastus Lateralis during static knee extensions (Mizuno et al 2004) and cycling (Koga et al 2008), although Kime et al (2005) concluded that spatial heterogeneity became reduced during heavy cycling. Thus it cannot be excluded that the observed sigmoid model of deoxy[Hb ?…”

Section: Representative Subjectsmentioning

confidence: 99%

Pattern of deoxy[Hb + Mb] during ramp cycle exercise: influence of aerobic fitness status

et al. 2009

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During ramp exercise the deoxy[Hb + Mb] pattern follows a sigmoid model [f(x) = f (0) + A/(1 + exp(-(-c +dx))], indicating a non-linear muscle blood flow (Qm)/oxygen uptake (VO25)-relationship. We hypothesised that in trained cyclists the sigmoid would display a rightward shift, due to an increased oxidative capacity and/or higher percentage of slow-twitch fibres. A total of 10 cyclists and 11 physically active students (PA students) performed a relative ramp exercise (+/-12 min) and a ramp25-exercise (25 W min(-1)). Deoxy[Hb + Mb] was measured at the M. Vastus Lateralis by NIRS, normalized to the total amplitude of the response and expressed as a function of absolute and relative (%peakP) work rate. The work rate corresponding to c/d (i.e.50% of the amplitude of the deoxy[Hb + Mb] response) was the only parameter of the sigmoid that differed significantly between cyclists (57.9 +/- 4.4% and 60.1 +/- 4.1%peakP in the relative and ramp25, respectively) and PAstudents (49.6 +/- 4.2% and 48.2 +/- 5.1%peakP, respectively), indicating a rightward shift of the sigmoid in the cyclists. These results suggest a change in the time course of C((a-v))O(2) as a function of aerobic fitness status.

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Inflection points of cardiovascular responses and oxygenation are correlated in the distal but not the proximal portions of muscle during incremental exercise

Cited by 18 publications

References 32 publications

Heterogeneity of muscle deoxygenation kinetics during two bouts of repeated heavy exercises

Heterogeneity of muscle deoxygenation kinetics during two bouts of repeated heavy exercises

Oxygenation and EMG in the proximal and distal vastus lateralis during submaximal isometric knee extension

Pattern of deoxy[Hb + Mb] during ramp cycle exercise: influence of aerobic fitness status

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