Inflammosome in the human endometrium: further step in the evaluation of the “maternal side”

D’Ippolito, Silvia; Tersigni, Chiara; Marana, Riccardo; Nicuolo, Fiorella Di; Gaglione, R; Rossi, Esther Diana; Castellani, Roberta; Scambia, Giovanni; Simone, Nicoletta Di

doi:10.1016/j.fertnstert.2015.09.027

Cited by 68 publications

(48 citation statements)

References 38 publications

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“…Studies have shown that both IL-18 and IL-18R showed increased mRNA expression in the human endometrium during the proliferative phase compared to the secretory phase. 19 Some limitations of this study are that it included a limited number of participants, which presumably is the reason why a difference in the expression of IL-18 in the endometrium of patients having PCOS with and without IR was not detected. Furthermore, secretary phase endometrium may also play an important role in the embryonic implantation, which needs to be further investigated.…”

Section: Discussionmentioning

confidence: 92%

Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

Yang

et al. 2017

Reprod. Sci.

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Women with polycystic ovary syndrome (PCOS) exhibit low implantation rate and high abortion rate. To explore the effect of low-grade chronic inflammation on endometrium of women with PCOS, we investigated the expression of interleukin 18 (IL-18) in the endometrium of 23 women with PCOS and 20 healthy women. Endometrial tissue samples were obtained during hysteroscopic surgery. We found that IL-18 was significantly increased in the endometrium of women with PCOS compared with normal groups. In overweight women, IL-18 was obviously overexpressed in the PCOS group compared to the healthy group. However, in normal-weight women, there was no statistically significant difference between the 2 groups, and there was no significant difference in IL-18 expression in patients having PCOS with or without insulin resistance. We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index.

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Section: Discussionmentioning

confidence: 92%

Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

Yang

et al. 2017

Reprod. Sci.

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“…Likewise, increased inflammatory cytokine levels (namely IL-18, LIF, MIF, IL-12, IFN-γ and ICAM-1) in the blood and endometrium were also associated with RPL (Comba et al 2015). Correspondingly, increased expression of the NALP3 inflammasome and its products IL-1β and IL-18 was observed in the endometrium of patient with RPL (D'Ippolito et al 2016). This evidence points toward a potential role of DAMPs in early pregnancy failure, although there are still many unresolved issues.…”

Section: Early Pregnancymentioning

confidence: 86%

Sterile inflammation and pregnancy complications: a review

Nadeau-Vallée¹,

Obari²,

Palacios³

et al. 2016

Reproduction

202

154

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Inflammation is essential for successful embryo implantation, pregnancy maintenance and delivery. In the last decade, important advances have been made in regard to endogenous, and therefore non-infectious, initiators of inflammation, which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs), and their involvement in reproduction has only recently been unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating effect on pregnancy outcomes. Many DAMPs, such as uric acid, high-mobility group box 1 (HMGB1), interleukin (IL)-1 and cell-free fetal DNA, have been associated with pregnancy complications, such as miscarriages, preeclampsia and preterm birth in preclinical models and in humans. However, the specific contribution of alarmins to these conditions is still under debate, as currently there is lack of information on their mechanism of action. In this review, we discuss the role of sterile inflammation in reproduction, including early implantation and pregnancy complications. Particularly, we focus on major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA (especially that of fetal origin) while giving an overview of the potential role of other candidate alarmins.Reproduction (2016) 152 R277-R292

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“…In the present study, tubal factor infertility was significantly higher among patients with a history of surgical abortion. Finally, molecular factors, especially inflammation factors, should be investigated in a further study …”

Section: Discussionmentioning

confidence: 99%

Association between induced abortion history and later in vitro fertilization outcomes

Wang

Sun

et al. 2018

Intl J Gynecology & Obste

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Inflammosome in the human endometrium: further step in the evaluation of the “maternal side”

Cited by 68 publications

References 38 publications

Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

Sterile inflammation and pregnancy complications: a review

Association between induced abortion history and later in vitro fertilization outcomes

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