Inflammatory Vitiligo

Pre- vs. post-pubertal onset of vitiligo: multivariate analysis indicates atopic diathesis association in pre-pubertal onset vitiligo

“…Atopic dermatitis, where pruritus is the major symptom, is characterized locally by a T‐helper 2 cytokine imbalance, and in contrast to vitiligo, clinical signs of inflammation such as erythema and oedema are the rule during flares. In vitiligo, clinical inflammation is rare but found in skin biopsies at the edge of progressing lesions 24 . However, in our study, we also found that pruritus was present in almost 19% of patients with pre‐pubertal vitiligo onset and in almost 25% of patients with post‐pubertal vitiligo onset.…”

Multivariate analysis of factors associated with early-onset segmental and nonsegmental vitiligo: a prospective observational study of 213 patients

“…Previously, symptoms and signs of inflammation have not been epidemiologically linked to vitiligo, in contrast to other chronic skin conditions such as atopic dermatitis, which is characterized locally by a Th2 cytokine imbalance, where erythema and oedema are common during flares. In vitiligo, inflammation has more often been reported in association with other diseases involving autoimmunity rather than isolated 18 . In our study, we found NSV to be almost three times more frequently preceded by pruritus compared with SV.…”

“…In addition, autoimmunity to thyroid antigens and presence of halo naevus were rarely found in SV confirming that an autoimmune environment is a hallmark of NSV. However, the initial pathomechanisms of SV may still be linked to infraclinical local inflammation 18 …”

Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes

“…Atopic dermatitis (AD) is characterized locally by a TH2 cytokine imbalance. In vitiligo, contrarily to AD, pruritus is not a usual sign, and clinical inflammation is rare but found in skin biopsies at the edge of progressing lesions (Ezzedine et al., ). Three susceptibility loci already associated with allergic disorders and T‐cell differentiation, namely TSLP, FOXP, and CTLA‐4 loci, have been found to be associated with vitiligo (Birlea et al., ).…”