Inflammatory Tinea Manuum due to &amp;lt;i&amp;gt;Trichophyton erinacei&amp;lt;/i&amp;gt; from an African Hedgehog

Alejandra, Coronado-Aguilar; Lourdes, Perez-Olivos Mirta de; Leonardo, Mayorga-Garibaldi Jorge; Jorge, Mayorga-Rodríguez; Córdova-Martínez, Erika; Francisca, Hernandez-Hernandez

doi:10.4236/aim.2018.812069

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…The crystallographic structure of Torpedo californica AChE (TcAChE) and human AChE (hAChE) pointed out that it includes two important binding sites with ligand, a peripheral anionic site (PAS) at the mouth and a catalytic active site (CAS) at the core. , Considering the important role of these two sites for AChE inhibition, we have employed both of these crystallographic structures for comparative evaluations. All the synthesized compounds were docked in XP mode on the active site of human acetylcholinesterase in complex with donepezil (PDB: 4EY7) and acetylcholinesterase in complex with anti-Alzheimer drug E2020 (PDB: 1EVE).…”

Section: Resultsmentioning

confidence: 99%

Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis, Biological, and Molecular Docking Studies

Pant,

Kumar K,

Rana

et al. 2024

ACS Chem. Neurosci.

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The most frequent type of age-related dementia is Alzheimer's disease. To discover novel therapeutic agents for Alzheimer's disease, a series of substituted pyrimidine derivatives were synthesized and evaluated for anti-Alzheimer's activity. All the synthesized compounds were validated by 1 HNMR, 13 CNMR, and HRMS to assess the structural conformance of the newly synthesized compounds. The synthesized compounds were then evaluated for their in vivo acute toxicity study. Evaluation of acute toxicity showed that none of the synthesized compounds showed toxicity up to 1000 mg/kg. After in vivo acute toxicity studies, the compounds were subjected to behavioral and biochemical studies. Compound N 4 -(4-chlorophenyl)-N 2 -(2-(piperidin-1-yl)ethyl)pyrimidine-2,4-diamine 5b (SP-2) displayed an excellent anti-Alzheimer's profile, while the rest of the compounds showed satisfactory results in comparison to donepezil. Docking studies confirmed the results obtained through in vivo experiments and showed that 5b (SP-2) showed a similar interaction to that of donepezil. Further, in silico molecular property predictions showed that 5b (SP-2) possesses favorable drug-likeness and ADME properties for CNS activity. These results implied that 5b could serve as an appropriate lead molecule for the development of anti-Alzheimer's agent.

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Section: Resultsmentioning

confidence: 99%

Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis, Biological, and Molecular Docking Studies

Pant,

Kumar K,

Rana

et al. 2024

ACS Chem. Neurosci.

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“…daily for 6 weeks [74]. Alejandra et al [75] studied in vitro antifungal susceptibility for T. erinacei. In this study, a high MIC for amphotericin B (4 µg/mL) and a resistance level for fluconazole (64 µg/mL) were found.…”

Section: Therapy In Humansmentioning

confidence: 99%

Hedgehog Dermatophytosis: Understanding Trichophyton erinacei Infection in Pet Hedgehogs and Its Implications for Human Health

Kottferová,

Molnár,

Major

et al. 2023

JoF

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Pet hedgehogs, which are increasingly favoured companions, have garnered attention due to their potential as carriers of zoonotic diseases. These small insectivorous mammals, native to Europe, Asia, and Africa, are commonly kept as pets. The encroachment of humans into hedgehog habitats has brought these animals closer to people, raising concerns about disease transmission. This article reviews the current knowledge regarding zoonotic disease associated with pet hedgehogs, with a particular focus on mycotic infections caused by Trichophyton erinacei. Data from various regions and hedgehog species are synthesised to assess the significance of pet hedgehogs as potential reservoirs and transmitters of zoonotic pathogens. Our study highlights the importance of understanding the health risks associated with pet hedgehogs and underscores the need for continued research to mitigate zoonotic disease transmission from these potentially disease-carrying companions.

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“…The crystallographic structure of Torpedo californica AChE (TcAChE) and recombinant human AChE (rhAChE) pointed out that it includes two important binding sites with ligand, a peripheral anionic site (PAS) at the mouth and a catalytic active site (CAS) at the core ,…”

Section: Introductionmentioning

confidence: 99%

Pyrimidine‐Triazolopyrimidine and Pyrimidine‐Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease

et al. 2018

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Acetylcholinesterase (AChE) is a critical enzyme, in Alzheimer's disease (AD) progression and hence has been subjected to intense drug discovery programme. Here, we report synthesis and testing of pyrimidine derivatives in conjugation with triazolopyrimidine based hybrid scaffold of AChE inhibitors for development of new molecules towards the treatment of AD. We used a multipronged approach employing computational, chemical and biological approaches to find the best inhibitor of AChE. Three molecules (10 e, 11 c and 12 b) derived from this scaffold inhibited AChE in nanomolar to micromolar range. Highest activity was shown by 2‐(4‐(6‐(quinolin‐8‐yloxy)pyrimidin‐4‐yl) piperazin‐1‐yl)nicotinonitrile (12 b) which has IC50 value of 36 nM. Inhibitory effect of 12 b was stronger for human AChE in neuronal cell extract compared to eelAChE. This activity is comparable to donepezil (IC50=38nM) which is considered as good standard among AChE inhibitors. The inhibitory activity of 12 b was also in agreement with molecular simulation studies which showed stable interaction of the 12 b with the catalytic active site as well as peripheral anionic site. Molecular simulation studies also indicated stronger interaction of 12 b with rhAChE than TcAChE. This was later confirmed in studies with neuronal cell extract where compound 12 b showed enzyme inhibition at 25 nM. Further this molecule was not found to be toxic or carcinogenic.

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Inflammatory Tinea Manuum due to <i>Trichophyton erinacei</i> from an African Hedgehog

Cited by 6 publications

References 19 publications

Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis, Biological, and Molecular Docking Studies

Novel Substituted Pyrimidine Derivatives as Potential Anti-Alzheimer’s Agents: Synthesis, Biological, and Molecular Docking Studies

Hedgehog Dermatophytosis: Understanding Trichophyton erinacei Infection in Pet Hedgehogs and Its Implications for Human Health

Pyrimidine‐Triazolopyrimidine and Pyrimidine‐Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease

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