Inflammatory status and prognosis of locally advanced non-small cell lung cancer

Galván-Román, José María; Curbelo, José; Aspa, Javier

doi:10.21037/jtd.2017.08.27

Cited by 2 publications

(1 citation statement)

References 25 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emerging evidence has indicated that inflammation is associated with tumor initiation and development, notably CRC (3–6). In addition, epidemiological studies have demonstrated that the development of CRC is closely associated with chronic inflammation (7).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑139‑5p regulates chronic inflammation by suppressing nuclear factor‑κB activity to inhibit cell proliferation and invasion in colorectal cancer

Zhu

Zhang

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

The inflammatory microenvironment, which mediates the initiation and malignant development of tumors, has been reported to be associated with microRNA (miRNA) dysregulation. In the present study, the expression of miR-139-5p was analyzed in colorectal cancer (CRC) cell lines SW480, HT29, HCT-8, LoVo and HCT116, aiming to investigate the function and mechanism of miR-139-5p in the regulation of the malignant phenotypes of CRC. miR-139-5p expression was found to be considerably downregulated in CRC cell lines compared with the human normal colon mucosal epithelial cell line NCM460. Subsequently, it was demonstrated that overexpression of miR-139-5p in colon cancer cell lines significantly suppressed the cell proliferation in vitro and in vivo. In addition, overexpression of miR-139-5p further inhibited the invasion ability of colon cancer cells in vitro, concomitantly with downregulation of key invasion-associated proteins, including matrix metalloproteinase 9 (MMP9) and MMP7. Furthermore, it was demonstrated that overexpression of miR-139-5p decreased the expression levels of inflammatory cytokines, including interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α), by suppressing nuclear factor (NF)-κB activity. Therefore, these findings collectively indicated that miR-139-5p regulated chronic inflammation by suppressing NF-κB activity in order to inhibit cell proliferation and invasion in CRC, thereby indicating a novel molecular mechanism in CRC therapy.

show abstract

Section: Introductionmentioning

confidence: 99%