Inflammatory status and its relationships with different patterns of postpartum luteal activity and reproductive performance in early lactating Holstein cows

Sina, Maryam; Dirandeh, E.; Deldar, Hamid; Shohreh, Bahram

doi:10.1016/j.theriogenology.2017.12.020

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…Pro-inflammatory and chemotactic cytokines play a key role in the recruitment and activation of phagocytic cells, which are main producers of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 12 . Sina et al 13 reported inflamed cows had lower progesterone concentrations and smaller corpora lutea (CL) compared to healthy cows at first and second estrous cycles after calving. Inflammatory condition prolonged day to first service, decreased pregnancy/AI, and increased days open 13 , 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

“…Sina et al 13 reported inflamed cows had lower progesterone concentrations and smaller corpora lutea (CL) compared to healthy cows at first and second estrous cycles after calving. Inflammatory condition prolonged day to first service, decreased pregnancy/AI, and increased days open 13 , 14 , 15 . The specific mechanisms by which uterine infection and biochemical profiles disrupt ovarian function are many and diverse 16 .…”

Section: Introductionmentioning

confidence: 99%

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Peripheral leucocyte molecular indicators of inflammation and oxidative stress are altered in dairy cows with embryonic loss

Dirandeh

Sayyar

Pirsaraei

et al. 2021

Sci Rep

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Objective of experiment was to determine whether oxidative stress (OS) and inflammation altered embryonic loss in dairy cows. Blood samples were collected at days 0, 16, 32 and 60 after timed (AI) from 200 Holstein cows to determine embryonic loss based on interferon-stimulated gene-15 (ISG15) mRNA expression (day 16) and ultrasound at day 32 and day 60. Leucocyte expressions of mRNA TLR2, TLR4, TNF-α, IL1B, IL10, STAT3 (inflammation), PTGS2, PTGES (prostaglandin synthesis), and PLA2G4A and ALOX5AP (eicosanoid metabolism) at days 0 and 16 were determined. Plasma redox status for antioxidant enzymatic activities of glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and concentrations of malondialdehyde (MDA) were determined at days 0, 16, 32 and 60. All antioxidant-redox responses were beneficially significant in pregnant cows diagnosed pregnant at day16 and sustained pregnancy to day 60 compared to non-pregnant cows at day16 or pregnant at day16 and lost embryos by days 32 or 60. The leucocyte mRNA expressions of TLR2, TLR4, STAT 3, IL1B, PTGS2, PLA2G4A and ALOX5AP were greater and PTGES was lower at day16 in pregnant cows that lost embryos early (P < 0.05). In conclusion peripheral leucocyte molecular indicators of inflammation and plasma indicators of OS were altered in pregnant cows undergoing embryonic losses compared to cows with a sustained pregnancy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral leucocyte molecular indicators of inflammation and oxidative stress are altered in dairy cows with embryonic loss

Dirandeh

Sayyar

Pirsaraei

et al. 2021

Sci Rep

Self Cite

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“…Cytokines are a group of endogenous inflammatory and immunomodulatory proteins produced by a large variety of cells that are thought to be important for host defence, wound healing and essential host functions. Excessive production and release of cytokines initiate widespread tissue which can result in organ dysfunction (Blackwell & Christman, 1996) and decline fertility (Sina, Dirandeh, Deldar, & Shohreh, 2018). The production of pro-and antiinflammatory cytokines has widely been studied.…”

Section: Introductionmentioning

confidence: 99%

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows

Bonsale

Sharifi

Dirandeh

et al. 2018

Reprod Domestic Animals

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The objective of this study was to consider endocannabinoid system as inflammatory markers in bovine endometrium to better understand the role of this system in regulating many of the functions that are related to inflammatory condition. At day 26 post-partum, fourteen cows were divided into two groups depending on the inflammatory condition: 1- subclinical endometritis (n = 7, with purulent or mucopurulent uterine discharge detectable in the vagina) and 2- healthy (n = 7, No (muco)) purulent discharge. Blood samples were collected at 26 and 30 days relative to calving to determine plasma tumour necrosis factor (TNF) and lipopolysaccharide-binding protein (LBP) concentrations; moreover, uterine biopsy was carried out on day 26 post-partum to measure mRNA abundance of TNF, interleukin-1B (IL1B), interleukin-6 (IL-6), C-X-C motif chemokine ligand 8 (CXCL8), endocannabinoid receptor (CNR2), N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD), fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and monoglyceride lipase (MGLL) by real-time PCR. Results showed mean plasma concentrations of TNF and LBP were lower in healthy cows compared to subclinical endometritis cows (p < .05). Relative mRNA expression for NAAA and FAAH was decreased (p < .05), and relative mRNA expression for CNR2 and NAPEPLD increased in cows with subclinical endometritis compared to healthy cows. In conclusion, relative mRNA expression of TNF, IL1B and CXCL8 and plasma concentration of LBP increased during inflammatory condition along with decreased endocannabinoids hydrolyzing enzyme (NAAA and FAAH), increased enzymes that synthesize endocannabinoids (NAPEPLD) and relative gene expression of the endocannabinoid receptor; together, these contribute to increased endocannabinoids levels during inflammation. Overall, we provide evidence that endocannabinoid system is altered in endometrium tissue during inflammation through increased mRNA expression of CNR2 and synthesis enzyme and decreased mRNA expression of hydrolyzing enzymes interfere with pro-cytokine production and signalling, which may interfere with the onset and progression of inflammation.

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“…Kekurangan nutrisi dalam tubuh dapat mengakibatkan hipofungsi ovarium, penurunan fungsi ovarium atau hipofungsi ovarium dalam jangka yang lama dapat menjadi atropi ovarium yang bersifat ireversibel serta panjangnya durasi anestrus postpartum kurang dari 60-90 hari. Selain faktor nutrisi adanya infeksi pada uterus postpartum dapat mengakibatkan keterlambatan involusi, kegagalan fertilitas, kawin berulang, service per conception kurang dari 1,5 dan calving interval kurang dari 12 bulan (Sina et al, 2018).…”

Section: Pendahuluanunclassified

Profile of Progesterone Levels After Administration of Gonadotropins in Dairy Cattle with Ovarian Hypofunction

et al. 2023

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This study aimed to evaluate the profile of progesterone in dairy cattle with ovarian hypofunction. A total of 10 cows in this study were evaluated three times in the collection phase, i.e. (F1) when the cow was diagnosed with ovarian hypofunction, (F2) when the cow was in heat and (F3) 21 days after artificial insemination to detect pregnancy. Samples in the form of blood serum were then analyzed using ELISA. As a result, the average time of heat in ovarian hypofunction cows was 7,4 days. Progesterone levels in F1 were 1,027 ng/ml, 2,774 ng/ml, 1,476 ng/ml, 2,256 ng/ml, 1,258 ng/ml, 1,758 ng/ml, 2,393 ng/ml, 0,592 ng/ml, 0,755 ng /ml, 1,876 ng/ml, respectively. Progesterone levels in F2 were 0,671 ng/ml, 0,517 ng/ml, 0,763 ng/ml, 0,598 ng/ml, 0,615 ng/ml, 0,537 ng/ml, 0,726 ng/ml, 0,643 ng/ml, 0,593 ng/ml, 0,975ng/ml, respectively. Progesterone levels in F3 were 15,642 ng/ml, 4,215 ng/ml, 17,327 ng/ml, 20,721 ng/ml, 5,796 ng/ml, 17,214 ng/ml, 15,815 ng/ml, 16,745 ng/ml, 4,632 ng /ml, 18,281 ng/ml, respectively. The pregnancy rate in hypofunctional cows treated with PG-600 in this study was 70%.

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Inflammatory status and its relationships with different patterns of postpartum luteal activity and reproductive performance in early lactating Holstein cows

Cited by 14 publications

References 37 publications

Peripheral leucocyte molecular indicators of inflammation and oxidative stress are altered in dairy cows with embryonic loss

Peripheral leucocyte molecular indicators of inflammation and oxidative stress are altered in dairy cows with embryonic loss

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows

Profile of Progesterone Levels After Administration of Gonadotropins in Dairy Cattle with Ovarian Hypofunction

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