Inflammatory Signature in Acute-on-Chronic Liver Failure Includes Increased Expression of Neutrophil Specific Genes ELANE, MPO and CD177 Running Title: Neutrophil Transcriptomics in ACLF
Abstract:Background and Aims: Acute-on-Chronic Liver Failure (ACLF) is associated with innate immune dysfunction and high short-term mortality. Neutrophils have been identified to influence prognosis in ACLF. Neutrophil biology is under-evaluated in ACLF. Therefore, we investigated neutrophil-specific genes and their association with ACLF outcomes.Methods: This is an observational study. Enriched polymorphonuclear cells, containing neutrophils, isolated from study participants in three groups- ACLF(n=10), chronic liver… Show more
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