Inflammatory serum profiles are consistent across independent exacerbations in COPD patients with a history of frequent exacerbations

Mackay, Alexander; Loza, Matthew; Branigan, Patrick; George, Siobhan; Donaldson, Gavin; Baribaud, Frédéric; Wedzicha, Jadwiga A.

doi:10.1183/13993003.congress-2015.pa407

Cited by 1 publication

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“…Hepcidin is a peptide hormone that play an important role in the systemic iron regulation through its interaction with the major iron export protein, the ferroportin [ 12 , 14 ]. In patients with chronic diseases such as chronic hepatitis C, hepatocellular carcinoma, and inflammatory bowel disease, levels of hepcidin were significantly reduced compared to control subjects [ 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several molecules and hormones are involved in the regulation of iron release and maintenance of its reservoirs. Processes related to iron transport, uptake, and export to the bloodstream and those involving inflammation are regulated by several molecules such as the iron-sensitive element/iron-sensitive protein (IRE/IRP) system, hepcidin, and hemojuvelin [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Furthermore, iron content can also be measured in specimens from patients as another marker of iron metabolism [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Iron Depletion in Systemic and Muscle Compartments Defines a Specific Phenotype of Severe COPD in Female and Male Patients: Implications in Exercise Tolerance

et al. 2022

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We hypothesized that iron content and regulatory factors, which may be involved in exercise tolerance, are differentially expressed in systemic and muscle compartments in iron deficient severe chronic obstructive pulmonary disease (COPD) patients. In the vastus lateralis and blood of severe COPD patients with/without iron depletion, iron content and regulators, exercise capacity, and muscle function were evaluated in 40 severe COPD patients: non-iron deficiency (NID) and iron deficiency (ID) (20 patients/group). In ID compared to NID patients, exercise capacity, muscle iron and ferritin content, serum transferrin saturation, hepcidin-25, and hemojuvelin decreased, while serum transferrin and soluble transferrin receptor and muscle IRP-1 and IRP-2 increased. Among all COPD, a significant positive correlation was detected between FEV1 and serum transferrin saturation. In ID patients, significant positive correlations were detected between serum ferritin, hepcidin, and muscle iron content and exercise tolerance and between muscle IRP-2 and serum ferritin and hepcidin levels. In ID severe COPD patients, iron content and its regulators are differentially expressed. A potential crosstalk between systemic and muscle compartments was observed in the ID patients. Lung function and exercise capacity were associated with several markers of iron metabolism regulation. Iron status should be included in the overall assessment of COPD patients given its implications in their exercise performance.

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