Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes

Oliveras-Cañellas, Núria; Latorre, Jessica; Santos-González, Elena; Lluch, Aina; Ortega, Francisco; Mayneris-Perxachs, Jordi; Fernández-Real, José-Manuel; Moreno-Navarrete, José María

doi:10.1016/j.biopha.2023.115428

Cited by 1 publication

(1 citation statement)

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“…LPS from the intestinal tract can inhibit the synthesis of mitochondria, damage the browning function of adipocytes, lead to the dysfunction of adipocytes, and greatly increase the risk of obesity-related diseases [64]. LPS can induce adipocytes to produce inflammatory factors at different stages of adipocyte differentiation, and at the same time, it can also lead to the increase in iron accumulation in adipocytes, destroy iron homeostasis, and then affect the metabolism of the whole body [65]. Also, obesity is associated with increased intestinal permeability in humans [66].…”

Section: Lps and Obesitymentioning

confidence: 99%

The Effect of Enteric-Derived Lipopolysaccharides on Obesity

Wang,

Lai,

Min

et al. 2024

IJMS

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Endotoxin is a general term for toxic substances in Gram-negative bacteria, whose damaging effects are mainly derived from the lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria, and is a strong pyrogen. Obesity is a chronic, low-grade inflammatory condition, and LPS are thought to trigger and exacerbate it. The gut flora is the largest source of LPS in the body, and it is increasingly believed that altered intestinal microorganisms can play an essential role in the pathology of different diseases. Today, the complex axis linking gut flora to inflammatory states and adiposity has not been well elucidated. This review summarises the evidence for an interconnection between LPS, obesity, and gut flora, further expanding our understanding of LPS as a mediator of low-grade inflammatory disease and contributing to lessening the effects of obesity and related metabolic disorders. As well as providing targets associated with LPS, obesity, and gut flora, it is hoped that interventions that combine targets with gut flora address the individual differences in gut flora treatment.

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Section: Lps and Obesitymentioning

confidence: 99%