Inflammatory response is associated with aortic dissection

Luo, Fang; Zhou, Xin; Li, Jianjun; Hui, Rutai

doi:10.1016/j.arr.2008.08.001

Cited by 167 publications

(147 citation statements)

References 46 publications

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“…Two risk models including preoperative and intraoperative variables have been developed by the International Registry of Acute Aortic Dissection and are generally used, but in recent studies several biochemical markers of vascular injury, thrombosis, and inflammation have been evaluated as contributors in the diagnosis of acute aortic dissection or as risk prediction tools. These studies suggest that AAD is associated with both tissue-level and systemic inflammatory reaction, and one of the inflammatory markers, C-reactive protein (CRP), is a useful marker to predict in-hospital and long-term adverse events (3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Lafçı¹,

Çiçek²,

Uzun³

et al. 2014

Turk J Med Sci

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vitro, the amino acids glutamic acid, aspartic acid, alanine, glutamine, proline, serine, and arginine induced rooting of explants in the presence of a-naphthalene acetic acid (Kamada and Harada 1979). Furthermore, it was found that while proline (10-200 mg L -1 ) increased the rooting percentage and number of roots per rooted explant of sweet cherry (Prunus avium L.) and sour cherry (Prunus cerasus L.), the root length was reduced (Baraldi et al. 1988).The different forms of nitrogen as well as its proportion can influence a number of factors in various in vitro cultures, such as cell division, the growth and development of somatic embryos, chlorophyll content, ribulose-1, 5-bisphosphate carboxylase/oxygenase activity, the electron transport rate, the photosynthetic rate, fresh mass, soluble protein concentration, and the osmotic pressure of the cell sap (Mashayekhi-Nezamabadi 2000). It has been reported that reduced nitrogen forms, particularly amides and amino acids, can improve cell proliferation, as well as regeneration in specific genotypes (Vasudevan et al. 2004).Methionine, a sulfur-containing amino acid, is a precursor of ethylene biosynthesis in plant tissues (Yang 1985). Besides its function as a protein constituent and its central role in the initiation of mRNA translation, methionine indirectly regulates a range of cellular processes as the precursor of S-adenosylmethionine (SAM) (Amir et al. 2002). Not only is SAM the primary biological methyl-group donor, but it is also the precursor of plant metabolites, including ethylene, polyamines, vitamin B 1 , and the iron chelator mugineic acid (Sun Abstract: In the present study, the effects of indole-3-butyric acid (IBA) alone and in combination with L-methionine were investigated on the morphogenic and biochemical responses in the shoot tip explants of the cherry rootstocks CAB-6P (Prunus cerasus L.) and Gisela 6 (Prunus cerasus × Prunus canescens). The best results for roots, regarding their number and the fresh and dry weight, were obtained with 2 mg L -1 IBA in both rootstocks. Maximum rooting percentage was with the combination of 2 mg L -1 IBA and 0.5 mg L -1 L-methionine. Root length was greatest in the control plants. L-methionine had an inhibitory effect on the leaf chlorophyll content of the CAB-6P rootstock and no effect in Gisela 6. L-methionine with the lowest IBA concentration (0.5 mg L -1 ) exhibited elevated levels of proline in the roots of the CAB-6P rootstock and depleted levels in Gisela 6. For the Gisela 6 rootstock, the leaf carbohydrate concentration was highest with 2 mg L -1 of IBA, whereas in the roots it was highest in the control. For the CAB-6P rootstock, the leaf carbohydrate concentration was not influenced by IBA with L-methionine, whereas the highest carbohydrate concentration in the roots was with the combinations of 0.5 mg L -1 IBA and 1 and 2 mg L -1 L-methionine. Taking into account the different parameters examined, it appears that chlorophyll and carbohydrates are the most accurate biochemical markers of the rooting ...

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Section: Introductionmentioning

confidence: 99%

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Lafçı¹,

Çiçek²,

Uzun³

et al. 2014

Turk J Med Sci

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“…Ayrıca, bu hüc-reler aort duvarındaki düz kas hücrelerinin apopitozunun geliş-mesinede katkı sağlarlar. Bu mekanizmalarla aort duvarının yeniden şekillenmesine, aort duvarının zayıflamasına ve medyal tabakanın bozulmasına sebep olurlar (8,23,24) . Bununla birlikte, trombozisinde diseksiyon patogenizinde rolü bulunmaktadır.…”

Section: 035unclassified

“…Aorttaki mekanik hasar, doku faktörünün dolaşıma salınmasına yol açar. Koagülasyon kaskadının ekstrinsik yolunun aktivasyonu ile yalancı lümende trombüs oluşur, trombüs gelişimi ile birlikte fibrinolitik sistemde aktive olur (19,23,25,26) . Daha önce bahsedildiği gibi bu alanda BKH'ninde aktif olarak bulunması AD gelişmesinde tromboinflamatuvar durumun olduğunu göstermektedir.…”

Section: 035unclassified

Tip A Akut Aort Diseksiyonu Olan Hastalarda Trombosit Lenfosit Oranının Uzun Dönem Mortalite Tahminindeki Rolü

Tabakçı¹

2017

Kosuyolu Heart Journal

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Giriş: Tip A akut aort diseksiyonu (AD) yüksek morbidite ve mortalitesinden dolayı hayatı tehdit edici, vasküler acil bir durumdur. İnflamasyon ve trombozun akut aort diseksiyonu ile ilişkili olduğu gösterilmiştir. Bu çalışmanın amacı trombo-inflamatuvar bir marker olan trombosit lenfosit oranı (TLO) ile cerrahi tamire giden akut AD'li hastalar arasında uzun dönem mortalite açısından bir ilişkinin olup olmadığını araştırmaktır. Sonuç: TLO, tromboz ve inflamasyonun ucuz ve basit bir belirtecidir. Başvurudaki artmış seviyeleri uzun dö-nem mortalitenin tahmininde değerli olabilir ve tip A akut AD'li hastaların risk derecelendirilmesinde faydalı bir belirteç olarak kullanılabilir.

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“…Accumulation of reports document that CD8 + T cells infiltrate aneurysm lesion both from human and mice tissues [13,14,17,26,31,46,54,[64][65][66][67][68][69][70][71]. The predominant cell types within the infiltrate in AAA tissues are CD3 + T cells (more than 50%), including CD4 + T cells and CD8 + T cells [17].…”

Section: Cd8 + T Cellsmentioning

confidence: 99%

“…The infiltration cells in all layers of the wall, most important pathologic features of aneurysms, include monocytes, lym-phocytes and plasma cells. In addition to release proteases, these cells secrete overwhelming inflammatory cytokines and participate in the destruction of the aortic wall and progression of enlargement and rupture [9,14,15]. Lymphocytes, apart from macrophages, are the predominant inflammatory cells found in aneurysm tissue [15,16].…”

mentioning

confidence: 99%

T lymphocytes and aortic aneurysms

Cheng

2014

Sci. China Life Sci.

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Aortic aneurysms are common and life threatening problems with high rates of death. The initiation and progression of aneurysms are characterized by extensive extracellular matrix degradation and immune cells invasion within arterial wall. During the pathogenesis of all aneurysms, inflammation and immune cells play a significant role. Although T cells are abundant in aneurysm tissue, their functions in initiation and propagation of aneurysms remain unclear. This review summarizes the current state of knowledge of T lymphocytes on this disease and focuses on potential mechanisms of specific T cell responses.

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Inflammatory response is associated with aortic dissection

Cited by 167 publications

References 46 publications

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Tip A Akut Aort Diseksiyonu Olan Hastalarda Trombosit Lenfosit Oranının Uzun Dönem Mortalite Tahminindeki Rolü

T lymphocytes and aortic aneurysms

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