Inflammatory Response in Infective Endocarditis

Deviri, E; Glenville, Brian

doi:10.1177/1721727x0700500201

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Subsequent analysis showed that the number of crises was associated with an altered alert status and/or to a mental slowing, while the length of the crisis (the critical period) was associated with memory alterations. [42][43][44][45][46] Again, only in the presence of frequent crises is there an alteration of mental alertness, and only during a crisis of threshold duration can we observe a deterioration of memory, as found in other studies. 11,16 The effect of the crisis is not independent of the type of epilepsy.…”

Section: Discussionsupporting

confidence: 88%

Epileptic EEG discharges and short non-convulsive crisis: Influence on cognitive and psychobehavioural functions in youths

Domizio¹,

Conte²,

Puglielli³

et al. 2008

CIM

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Purpose: Learning and behavioural difficulties often occur in benign childhood epilepsy. In recent years, several electroencephalogram (EEG) characteristics have been related to the occurrence of learning and behavioral problems. We determined if the cognitive characteristics of epileptic children depend exclusively on illness factors, or if epileptic electroencephalogram discharges during the crisis contribute to these changes. Methods: We studied a randomly selected group of 150 youths with short non-convulsive crises, who completed cognitive testing and electroencephalographic studies. The inclusion criteria were: undefined crisis, variations in cognitive function and/or frequent epileptiform discharges on the electroencephalogram. Results: Previous research indicates that the type of epilepsy and the patient’s educational level can influence cognitive functioning. The electroencephalographic epileptic discharges during the crisis has been found to influence cognitive transitory functions such as vigilance or swiftness of mental functions. The type of epilepsy is correlated statistically with impairment of learning ability tests: reading (F, 5.487, P = 0.005) and mathematics (F, 3.007, P ≤ 0.05). In addition, 40% of the epileptic patients had behavioural disordered versus 16% for the control group (P < 0.02).

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Section: Discussionsupporting

confidence: 88%

Epileptic EEG discharges and short non-convulsive crisis: Influence on cognitive and psychobehavioural functions in youths

Domizio¹,

Conte²,

Puglielli³

et al. 2008

CIM

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“…Fibrinogen is elevated in HD patients, influences arterial remodelling, and correlates positively with CIMT (29). Higher concentrations of these substances may be involved in the atherogenic inflammatory process in predialysis and HD patients (46)(47).…”

Section: Discussionmentioning

confidence: 99%

Circulating Plasma Antioxidants, Inflammatory Markers and Asymptomatic Carotid Atherosclerosis in End-Stage Renal Disease Patients: A Case Control Study

Riccioni¹,

Scotti

Petruzzelli

et al. 2010

Int J Immunopathol Pharmacol

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Few studies have been conducted on the relationship between antioxidant plasma vitamin concentrations, inflammatory markers and carotid atherosclerosis with inconclusive results in end-stage renal disease (ESRD) patients. A case-control study was performed to investigate the relationship between plasma antioxidant concentrations, inflammatory markers, and carotid intima-media thickness (CIMT) in healthy subjects and in patients undergoing hemodialysis (HD). We enrolled 40 subjects (20 healthy, 20 with ESRD) asymptomatic for carotid atherosclerosis. After carotid ultrasound investigation (CUI), medical history data, physical examination, venous blood samples were collected. These were analyzed for concentrations of antioxidant vitamins (A, E), carotenoids (lycopene, β-carotene), inflammatory markers (C-reactive protein, fibrinogen), and lipid profile. Low concentrations of vitamin A, vitamin E, lycopene, and β-carotene were significantly associated with carotid atherosclerosis in patients with ESRD (p<0.001). In addition, high concentration of low density lipoprotein cholesterol and total cholesterol (p<0.01), C-reactive protein and fibrinogen (p<0.001) were also associated with carotid atherosclerosis, while other laboratory parameters considered (high density lipoprotein cholesterol and triglycerides) were not significantly associated with carotid atherosclerosis. A regular intake of foods rich in antioxidant vitamins with low fat concentrations may slow the progression of atherosclerotic process in this group of patients.

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“…These concepts support the conclusion that IgE can signal the transition from inflammatory cell rolling to cell arrest [35] . We believe that there are some correlations between HUCMC-induced IL-8 and tryptase release since it has been reported that blocking tryptase reduces IL-8 significantly, a phenomenon not related with histamine production [31,[53][54][55][56] . However, more studies on IL-8 production by mast cells in vivo and in vitro are required to clarify the specificity of its proinflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Expression and Secretion of CXCL8 (IL-8), Release of Tryptase and Transcription of Histidine Decarboxylase mRNA by Anti-IgE-Activated Human Umbilical Cord Blood-Derived Cultured Mast Cells

Castellani

Shaik²,

Perrella³

et al. 2007

Neuroimmunomodulation

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Activation of cytokine receptors and alterations in cytokines are thought to play important roles in neuronal dysfunction and in the pathogenesis of the nervous system diseases. CXCL8 (IL-8) is a CXC chemokine with chemotactic and inflammatory properties. Chemokines control mast cell infiltration in several inflammatory diseases, including stress and neurological dysfunctions. Using isolated human umbilical cord blood-derived cultured mast cells (HUCMC) from hematopoietic stem cells CD34+, mast cells were immunologically activated with anti-IgE at concentrations of 1, 5, 10 and 20 µg/ml leading to the dose-dependent production of IL-8 (p < 0.05). The increase in IL-8 mRNA expression was also noted when the cells were treated with anti-IgE at 10 µg/ml for 6 h. Immunologically activated HUCMC provoked the generation of tryptase in a dose- and time-dependent manner. We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine. Taken together, these results confirm that anti-IgE-activated mast cells release inflammatory mediators including CXCL8, a CXC chemokine which regulates several biological effects of mast cells, e.g. chemoattraction, and possibly causes cell arrest.

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Inflammatory Response in Infective Endocarditis

Cited by 14 publications

References 42 publications

Epileptic EEG discharges and short non-convulsive crisis: Influence on cognitive and psychobehavioural functions in youths

Epileptic EEG discharges and short non-convulsive crisis: Influence on cognitive and psychobehavioural functions in youths

Circulating Plasma Antioxidants, Inflammatory Markers and Asymptomatic Carotid Atherosclerosis in End-Stage Renal Disease Patients: A Case Control Study

Expression and Secretion of CXCL8 (IL-8), Release of Tryptase and Transcription of Histidine Decarboxylase mRNA by Anti-IgE-Activated Human Umbilical Cord Blood-Derived Cultured Mast Cells

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