Inflammatory reaction, clinical efficacy, and safety of bacterial cellulose wound dressing containing silk sericin and polyhexamethylene biguanide for wound treatment

Napavichayanun, Supamas; Ampawong, Sumate; Harnsilpong, Tavornchai; Angspatt, Apichai; Aramwit, Pornanong

doi:10.1007/s00403-018-1871-3

Cited by 41 publications

(37 citation statements)

References 41 publications

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“…BC‐based dressings continue to show high healing performance over conventional materials, such as gauze, without considering minimizing the pain suffered by the patient both during the first days after the wound was inflicted or at the time of the dressing removal . During the last years, the studies using BC as a base for the development of wound‐healing materials kept showing its versatility.…”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

View full text Add to dashboard Cite

show abstract

“…During implantation studies conducted on guinea pigs, the deep dermal defects showed full recover without scar formation up to a 2×4cm area [107]. The combination of BC and silk have also been implemented as skin grafts showing less inflammatory response compared to other marketed skin graft products as well as inducing relative improvements in comfort based on test subject surveys [114]. In addition to its extensive applications in wound healing and tissue regeneration, BC has shown to possess properties amenable for implementation in drug delivery technologies.…”

Section: Medical Application and Marketed Products From Bacterial Celmentioning

confidence: 99%

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Sandhu¹,

Arpa²,

Chen³

et al. 2019

rpm

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Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineering are pushing the value of this biomaterial to new levels. This review provides and in-depth discussion of these most recent approaches in processing as well as physical, chemical, and genetic modification of bacterial cellulose toward further improvement and expansion of its functionality. In addition, we provide specific attention to the marketed applications of the resulting engineered materials for medical research and conclude with prospective areas of consideration for expanding the clinical utility of this biomaterial to new directions.

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“…Napavichayanun et al. [ 12 ] combined sericin with PHMB to develop a dressing that was beneficial to the wound. The modified cotton fabric prepared by Doakhan et al.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Cytotoxicity Evaluation of Zinc Oxide–Bacterial Cellulose–Chitosan Hydrogels for Antibacterial Dressing

Jiang

Zhou²

2020

Macro Chemistry & Physics

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Lin et al. evaluated the cell compatibility and antibacterial activity of bacterial cellulose-chitosan (BC-CS) membranes in vitro. [6] BC is widely used in antibacterial aspects. Wu et al. proposed a preparation method of slow-released antimicrobial wound dressing. [7] Common antibacterial agents for improving BC include benzalkonium chloride, [8] copper, silver, ZnO nanoparticles, sulfadiazine silver, [9] polyhexamethylene guanidine hydrochloride (PHMB), [10] sericin, CS, propolis, [11] and so on. Recently, some researchers were interested in sericin. Napavichayanun et al. [12] combined sericin with PHMB to develop a dressing that was beneficial to the wound. The modified cotton fabric prepared by Doakhan et al. using sericin and nano-TiO 2 had well antibacterial activity and durability. [13] Maneerung et al. used a chemical reduction method to prepare BC antibacterial wound dressings containing silver nanoparticles. [14] CS was obtained by deacetylation of chitin, which was the most abundant naturally occurring biopolymer after cellulose. [15] CS is considered to be a promising biomedical material because of its good biocompatibility, rich functional groups, nontoxicity, degradability, and antibacterial properties. Although CS and BC had such significant advantages, related studies had shown that they were rarely used alone. The reason was that the hydrogels formed by CS had low mechanical strength [16] such as poor flexibility and low ability to elongate and the BC hydrogels itself did not have antibacterial properties. [17,18] CS could be combined with other biopolymers to improve properties. Wu et al. [19] enhanced the mechanical strength of CS by adding oxidized chitin nanocrystals to the CS film. To the best of our knowledge, zinc oxide had not been reported in CS and BC composite hydrogels. Some studies only considered a single factor, which leaded to some inevitable defects. For example, the composite hydrogels were formed by using BC and CS, but the antibacterial property was low due to partial reaction of the amino group on the CS. For example, Liang et al. found that the antimicrobial efficiency of composite films against Escherichia coli was reduced. [20] On the other hand, excessive zinc oxide can cause severe cytotoxicity. Vandebriel et al. suggested that zinc oxide nanoparticles may be cytotoxic In this work, a kind of novel antibacterial and biocompatible composite hydrogels composed of zinc oxide, bacterial cellulose (BC), and chitosan (CS) are prepared via immersing the oxidized BC hydrogels in CS solution and then combining zinc oxide in alkaline environment. The structure and properties of the composite hydrogels are characterized by different techniques. The results of Fourier transform infrared spectroscopy and X-ray diffraction prove the successful preparation of composite hydrogels. Scanning electron microscopy is used to study the microscopic morphology of hydrogels. The results show that the zinc oxide particles are successfully attached to the bacterial cellulose. From the results of t...

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Inflammatory reaction, clinical efficacy, and safety of bacterial cellulose wound dressing containing silk sericin and polyhexamethylene biguanide for wound treatment

Cited by 41 publications

References 41 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Preparation, Characterization, and Cytotoxicity Evaluation of Zinc Oxide–Bacterial Cellulose–Chitosan Hydrogels for Antibacterial Dressing

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