Inflammatory psuedo-tumor of the spleen

Singh, Sunita; Chhabra, Sonia; Modi, Shilpi; Marwah, Nisha; Rawal, Anju; Arora, B

doi:10.4103/0377-4929.56169

Cited by 2 publications

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“…Most IMTs occur in the lungs and airways of young patients. However, other organs, including mesentery, omentum, stomach, small intestine, large intestine, mediastinum, retroperitoneum, liver and bladder, have been documented (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Among these extrapulmonary IMTs, 43% arise in the mesentery and omentum (29).…”

Section: Discussionmentioning

confidence: 99%

“…IMT used to be considered as an inflammatory pseudotumor, xanthogranuloma, plasma-cell granuloma, plasma-cell pseudotumor or an inflammatory myofibroblastic tumor. IMT commonly occurs in the lung, mesentery, omentum and retroperitoneum, but it may also be observed in the extremities, head and neck region, liver, spleen, thyroid, gastrointestinal tract, genitourinary tract and other systems (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The tumors usually follow a benign course, but recurrences have been documented in up to 25% of cases.…”

Section: Introductionmentioning

confidence: 99%

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Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Zhao¹,

Wang

et al. 2012

Oncology Letters

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Abstract. Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our hospital due to a mass found in her right breast. Mammogram and ultrasound revealed a well-circumscribed mass and surgery was performed. Histopathologically, the lesion was composed of spindle and inflammatory cells, including plasma cells and lymphocytes. Mitotic figures were not observed. Immunohistochemically, the tumor cells were positive for SM-actin, anaplastic lymphoma kinase (ALK) and vimentin and focal positive for desmin, but negative for NSE, S-100, CD117, CD34, NF, CD21, CD35 and CD68. Thus, we made a diagnosis of IMT and advised regular follow-up. However, the patient had local recurrence and metastasis to the left groin area 3, 7 and 10 months after the initial surgery. Notably, the histopathological characteristics of the recurrent and metastatic foci were similar to those of the initial specimen, but mitotic figures were clearly observed. Thus, we conclude that IMT shows occasionally malignant biological behavior although it is a neoplasm of intermediate biological potential that frequently recurs and rarely metastasizes. We advise that clinical physicians should regularly follow up patients after focal resection for IMT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Zhao¹,

Wang

et al. 2012

Oncology Letters

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Inflammatory Pseudotumor of the Spleen Masquerading as Splenic Malignancy

et al. 2016

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Inflammatory pseudotumors (IPTs) of the spleen are extremely rare, benign tumors of unknown etiology, and are most frequently detected incidentally. We report a case of IPT of the spleen in a 19-year-old male, who presented to the Hamdard Institute of Medical Sciences and Research, New Delhi, with a history of pain and heaviness in the left hypochondrium. On clinical examination, splenomegaly was detected. Ultrasonography and contrast-enhanced computed tomography of the abdomen revealed an enlarged spleen with a mass lesion completely occupying the lower pole of the spleen. Therefore, a diagnosis of splenomegaly with a malignant splenic lesion was suggested. Open splenectomy was performed. On gross examination, a well-circumscribed nodular growth measuring 9 × 8 × 5 cm in diameter was seen on the lower pole of the spleen, which on cut section appeared tan white with foci of yellowish discoloration. Microscopic examination of the nodular growth revealed spindle cells in a hyalinized stroma with inflammatory infiltration of predominantly plasma cells and lymphocytes. On immunohistochemistry, the spindle cells were positive for smooth muscle actin. A diagnosis of IPT of the spleen was rendered following histopathology testing. Splenectomy is both diagnostic and curative for this rare entity, and prognosis is usually favorable following the procedure.

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Inflammatory psuedo-tumor of the spleen

Cited by 2 publications

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Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Inflammatory Pseudotumor of the Spleen Masquerading as Splenic Malignancy

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