Inflammatory pseudotumour of lymph nodes.

New, N.E.; Bishop, Paul; Stewart, Mark A.; Banerjee, Shiladitya; Harris, Martin

doi:10.1136/jcp.48.1.37

Cited by 12 publications

(10 citation statements)

References 8 publications

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“…In addition, EBV was detected by in situ hybridization in one case, but only in infiltrating lymphocytes. Other reports on nodal IPT, similar lack of expression of FDC markers was described [43,45].…”

Section: Inflammatory Pseudotumor In Lymph Nodes and Spleenmentioning

confidence: 80%

“…Proportion of spindle and inflammatory cell components varied, predominating in some areas or mostly replaced by fibrous content in others. Lesions tended to follow the vascular axis, through the hilum [16,43]. Among the cases in which an etiological agent can be detected, pathologist should search for infection, especially for T. pallidum, as it has been shown that luetic lymphadenitis may also cause lymph node IPT [18,44].…”

Section: Inflammatory Pseudotumor In Lymph Nodes and Spleenmentioning

confidence: 99%

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Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell proliferation. This tumor occurs primarily in lymph nodes, especially cervical and axillary, however, involvement of extranodal sites such as the tonsils, spleen, liver, and gastrointestinal tract has been reported. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is a rare, distinctive histological subtype of this low-grade malignant neoplasm, with consistent Epstein-Barr virus (EBV) association. The differential diagnosis with other fibro-inflammatory tumor proliferations, as inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT), may be challenging. In the present article, two cases of IPT-like FDCT of the spleen are presented, with a broad overview of the literature: one 77-year-old male and one 70-year-old female. A large immunohistochemical panel should be used for diagnosis, as no single specific and totally sensitive markers are available, including markers for CD21, CD23, CD35, CNA42, and clusterin. Individual cases may express one or more of these markers, so that all of them should be investigated. In situ hybridization for EBV is constantly positive. Immunostaining for ALK should be negative, as it is present in roughly half of the cases of IMT. This panel should be used in combination of clinical, laboratory, and topographic evidences. Importantly, inclusion of this lesion as a possible option in clinical and pathological investigation represents the basis for a correct diagnosis.

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Section: Inflammatory Pseudotumor In Lymph Nodes and Spleenmentioning

confidence: 80%

Section: Inflammatory Pseudotumor In Lymph Nodes and Spleenmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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“…In 15 to 40% of patients they are asymptomatic. When it is located in the small intestine, it generally presents as a surgical emergency [ [25] , [26] , [27] ]. In our case, the patient presented obstructive symptoms after the previously performed umbilical hernioplasty, which generated confusion since we consider that this condition was due to a complication of the procedure.…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory studies are not very specific. Imaging studies are taken for another pathology and can be found as incidental tumors, which suggest a benign process, using ultrasound and tomography, encapsulated hypodense lesions can be observed [ [25] , [26] , [27] ]. In our case, the office studies did not reveal the presence of a tumor, the diagnosis was made once the histopathological study was completed.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myophibroblastic tumor of the proximal ileon in a patient with complicated umbilical hernia: A case report and literature review

Romero

Cárdenas²,

Vázquez

et al. 2021

International Journal of Surgery Case Reports

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Introduction Inflammatory myofibroblastic tumors are neoplasms that occur infrequently, mainly affects children and young adults. It is an intermediate grade fibrotic multinodular neoplasm. Description of the case We present the case of a 47-year-old female patient, who underwent emergency umbilical hernioplasty, later developed intestinal obstruction secondary to an inflammatory myofibroblastic tumor. Discussion In 1939 Brunn described it for the first time, later in 1954 Umiker named it “Inflammatory Myofibroblastic Tumor”. The symptoms are nonspecific. In 15 to 40% of patients they are asymptomatic. Cells positive for actin, smooth muscle, vimentin and desmin, in 3367% of cases the cells are positive for ALK, which is present in some malignant lesions. The recommended treatment is radical resection. Conclusion The diagnosis is established by histopathological study, surgery is the cornerstone of treatment.

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“…Inflammatory myofibroblastic tumour (IMT) is a relatively rare lesion composed of a variety of inflammatory cells infiltrating in mesenchymal myofibroblastic spindle cells. [1][2][3][4] It has generally been considered a benign pseudosarcomatous disease arising from the soft tissues. It was initially described in the lung, but subsequently recognized that virtually any organ can be involved.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory myofibroblastic tumour of the spleen: A case report and literature review

Chen¹,

Wei²,

Guo³

2010

Surgical Practice

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Inflammatory myofibroblastic tumour (IMT) is a benign lesion consisting of myofibroblastic spindle cells with an inflammatory cells infiltration. Their behaviour is generally not aggressive, but in some cases they can simulate malignant neoplasms, from which they are impossible to be distinguished before excision. We report a case of IMT originating from the spleen in a 65‐year‐old woman. She underwent splenectomy with the diagnosis of lymphoma, whereas the final pathological diagnosis was IMT. By referring to previously diagnosed IMT cases in our hospital and relevant literature, we conclude that, as a result of a lack of clinical and imaging features, surgical excision is the primary choice of IMT, in order to obtain a definitive diagnosis as well as to avoid recurrence and metastasis, and the subsequent follow up is necessary.

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Inflammatory pseudotumour of lymph nodes.

Abstract: Aim-To describe the clinical, histological and immunohistochemical features in four cases of an uncommon benign lymph node lesion which may mimiic a neoplastic process.

Cited by 12 publications

References 8 publications

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Inflammatory myophibroblastic tumor of the proximal ileon in a patient with complicated umbilical hernia: A case report and literature review

Inflammatory myofibroblastic tumour of the spleen: A case report and literature review

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