Inflammatory pseudotumor of the choroid plexus

Abstract

The authors report a case of inflammatory pseudotumor that developed in the choroid plexus of the lateral ventricle. The patient was a 73-year-old man who had undergone surgery for rectal cancer at another hospital 5 years earlier. He was referred to the authors' department, with his chief symptoms consisting of disorientation, right hemiparesis, and gait disorder that had gradually developed during the preceding month. On computed tomography and magnetic resonance imaging, a well-demarcated and homogeneously contrasted tumorous lesion was noted in the region from the trigone to the medial wall of the inferior horn of the left lateral ventricle. Expansion of the inferior horn was also evident. Intraoperative findings showed that the tumor originated from the choroid plexus of the lateral ventricle, and the histopathological diagnosis was inflammatory pseudotumor. There are only 4 previously reported cases of inflammatory pseudotumor that developed in the choroid plexus; the authors review the literature and discuss the clinicopathological characteristics of the condition.

Inflammatory Pseudotumor in the Lateral Ventricle with Repeated Bleeding-Case Report-

“…Xanthogranuloma, neurosarcoidosis, and low-grade astrocytoma are unlikely to bleed 2) . In previously reported cases of intraventricular pseudotumor, there also was no tumor bleeding [1][2][3]6,8) . However, in our case, repeated bleedings was characteristic.…”

“…Inflammatory pseudotumor of the CNS is a condition often affecting young adults with a slight male preponderance 7) . Miyahara et al 6) reported that there have been only 5 case reports of inflammatory pseudotumor that developed in the choroid plexus (Table 1). In these cases, alterations in consciousness and contralateral hemiparesis were the initial symptoms, and the masses showed a contrast enhancement.…”

“…Differential diagnosis should include an inflammatory pseudotumor when there is a localized, solitary, nontumorous, and space-occupying lesion. Inflammatory pseudotumor is comprised of intermingling collagen fibers, inflammatory cells such as lymphocytes and/or plasma cells, and mesenchymal cells such as fibroblasts and myofibroblasts 6) . It destroys the structure from which it is originated 6) .…”

“…Inflammatory pseudotumor is comprised of intermingling collagen fibers, inflammatory cells such as lymphocytes and/or plasma cells, and mesenchymal cells such as fibroblasts and myofibroblasts 6) . It destroys the structure from which it is originated 6) . The pathophysiology of inflammatory pseudotumor remains obscure.…”

Inflammatory Pseudotumor in the Lateral Ventricle

“…Only 9 cases of IP in the ventricles have been reported in detail (Table 1), 1,4,5,8,10,11,13,14) occurring in 2 females and 7 males aged 15-73 years (mean 49 years), indicating a tendency to occur in middle-aged or older men. 10) Eight of 9 cases developed in the lateral ventricle, with the remaining case developing in the fourth ventricle.…”