“Inflammatory Pseudotumor” of Liver with Occlusive Phlebitis: Report of a Case in a Child and Review of the Literature

Abstract

An unusual "tumor" involving the right lobe of the liver of a young child is reported. Morphologically, the lesion had the features of "inflammatory pseudotumor." We were able to find only one previous report of a similar case in the literature. Unusual changes, which may be designated "occlusive phlebitis," were present in the medium-sized and large veins. Histologically, the lesion, including the vascular changes, had similaritites to the entities included in the group of "multifocal fibrosclerosis." It is believed that these unusual vascular changes, which have also been observed in a case of "inflammatory pseudotumor" of the parotid gland, probably contributed to the disease process.

Inflammatory Pseudotumor of the Liver in Patient with Type 2 Diabetes

“…The results of laboratory tests were as follows: white blood cell count -12.360/μL (normal range 4.000-10.500/μL), neutrophils -76.2% (normal range 45-70%), lymphocytes -15.7% (normal range 20-45%), monocytes -5.3% (normal range 3.0-8.0%), red blood cell count -3.53x10 6 /μL (normal range 3.8-5.2x x10 6 Other results of biochemical analysis of the blood including serum platelet count and levels of serum total bilirubin, alkaline phosphatase (ALP), amylase and lipase were within normal limits. Laboratory parameters of renal function and serum level of tumor markers (α-fetoprotein) -remained within normal range.…”

“…It may arise in nearly every site of the body (e.g. breast, kidney, thyroid, salivary glands, larynx, spleen, stomach, brain, omentum, mesentery, orbit), but most commonly develops in the lung and the liver [1][2][3][4][5][6][7][8]. The first description of hepatic localization appeared in 1953 [9].…”

“…The first description of hepatic localization appeared in 1953 [9]. In most cases it affects adults, but in Asia, the hepatic IPT occurs often in children and young adult persons [2,6]. IPT usually presents as an asymptomatic [5], slowly growing, unilateral mass accompanied by unspecific symptoms like fever, malaise, abdominal pain and rarely vomiting, jaundice and weight loss [3,4,6,7,10].…”

“…In most cases it affects adults, but in Asia, the hepatic IPT occurs often in children and young adult persons [2,6]. IPT usually presents as an asymptomatic [5], slowly growing, unilateral mass accompanied by unspecific symptoms like fever, malaise, abdominal pain and rarely vomiting, jaundice and weight loss [3,4,6,7,10]. It typically forms the solitary large (maximum dimension range from 2 to 22 cm) mass and accounts for 0.4% of all focal liver lesions [2,7].…”

Inflammatory pseudotumours of the liver: A spectrum of presentation and management options

“…Inflammatory pseudotumours have also been called inflammatory myofibroblastic tumour, plasma cell granuloma, histiocytoma and fibroxanthoma. Someren histologically classified inflammatory pseudotumours into three groups, namely(1) xanthogranuloma-type pseudotumours, (2) plasma cell granuloma-type pseudotumours and (3) sclerosing pseudotumours 1,2 .…”