Inflammatory pseudotumor in head and neck

Segawa, Yuichi; Yasumatsu, Ryuji; Shiratsuchi, Hideki; Tamae, Akihiro; Noda, Teppei; Yamamoto, Hidetaka; Komune, Shizuo

doi:10.1016/j.anl.2013.11.002

Cited by 29 publications

(26 citation statements)

References 14 publications

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“…Surgical resection, i.e. mastoidectomy, in combination with steroid therapy has been the most common treatment of choice amongst these patients 15 . Of the six patients in our series, three of them underwent complete mastoidectomy with biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…IPT lesions tend to be very responsive to corticosteroid treatment. Prior studies have demonstrated an initial response rate of approximately 80% 15 . In our case study, the patients with IPT extension past the temporal bone required adjuvant therapy, suggesting that intracranial involvement may be a predictor of the necessity of adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Ortlip¹,

Drake²,

Raghavan³

et al. 2017

Otology &Amp; Neurotology

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Objective: Inflammatory pseudotumor of the temporal bone is a benign, idiopathic inflammatory process that is locally invasive and a cause of significant morbidity. This study reviews our experience with seven patients and is currently the largest series to date. Study Design: Retrospective review from January 1, 2014 to January 1, 2016. Setting: Single tertiary medical center. Patients: There were five male and two female (n = 7) subjects with a diagnosis of temporal bone inflammatory pseudotumor. The mean age at presentation was 41 years old. The most common presenting symptoms were hearing loss (7/7) and headache (4/7). Four patients demonstrated an inflammatory aural polyp. Two patients experienced facial nerve paralysis. Intervention(s): Seven patients underwent computed tomography and six underwent magnetic resonance imaging. Corticosteroids and antibiotics were the initial treatment of choice. Five patients also underwent surgery. As adjuvant therapy, two patients received Rituximab, one patient received radiation, and one received mycophenolate mofetil. Main Outcome Measure(s): Clinical courses were followed with focus on symptoms, disease recurrence, duration, and treatment. Mean follow-up was 17.8 months. Results: The primary lesions demonstrated T2 hypo-intensity and enhancement as well as diffuse dural thickening on magnetic resonance imaging in five of six patients. Histopathology demonstrated chronic inflammation in the setting of hyalinized fibrosis (7/7). All the patients are currently symptomatically stable. Conclusion: Inflammatory pseudotumor of the temporal bone can cause devastating effects on neurological function and quality of life. Recognition of characteristic imaging and histopathology can expedite appropriate treatment. Patients may require chronic steroid therapy. Adjunctive therapy with radiation and immuno-modulation are currently being explored.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Ortlip¹,

Drake²,

Raghavan³

et al. 2017

Otology &Amp; Neurotology

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“…Several synonyms exist in human literature (Knight et al, 2009), contributing to confusion surrounding the comprehension of this uncommon disease. This condition has been reported in humans and animals (horses, dogs and cats) with no particular age or sex incidence and with different localisations (Cooper and Valentine, 2002;van der Woerdt, 2008;Loderstedt et al, 2010;Gude et al, 2011;Segawa et al, 2014). In humans, clinical or subclinical muscle injury and denervation injury have been proposed as a possible aetiology, however such correlations have not been proved (Cooper and Valentine, 2002; The Armed Forces Institute of Pathology, 2007;Knight et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…They have been reported in humans (Gude et al, 2011;Segawa et al, 2014) and occasionally in animals (Cooper and Valentine, 2002;van der Woerdt, 2008;Knight et al, 2009;Loderstedt et al, 2010). Aetiology of muscle pseudotumours remains unknown, although several hypotheses have been postulated.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal paralysis associated with a muscle pseudotumour in a young dog

Rizzo¹,

Benetti²,

Ballatori³

et al. 2017

Open Vet J.

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An 18-month-old male entire Bloodhound dog was presented with a six-week history of progressive inspiratory dyspnoea, stridor, dysphonia and exercise intolerance. CT scan performed elsewhere had revealed the presence of an unencapsulated nodular mass (3x1x5 cm) dorsal to the larynx and first tracheal rings. Laryngoscopy demonstrated the presence of bilateral laryngeal paralysis and distorted laryngeal architecture suggestive of extraluminal compression. Histopathology results of incisional biopsies from the mass were suggestive of a benign non-neoplastic muscular lesion. Surgery was performed to manage laryngeal paralysis and attempt mass excision. A second histopathology examination confirmed an inflammatory and dysplastic lesion suggestive of a pseudotumour. All clinical signs resolved after surgery and at the 13 months follow-up the dog remains asymptomatic. To the authors' knowledge, this is the first report of a case of laryngeal paralysis caused by a muscle pseudotumour in a young dog.

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“…IMT has an approximate 25% local recurrence rate, with <5% risk of regional/distant metastasis 6. Historically, the vast majority of cases of head and neck IMT have proved to be responsive to treatment, typically full excision, with few reported instances of persistent disease or mortality reported in the literature (table 1).…”

Section: Introductionmentioning

confidence: 99%

Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity

et al. 2018

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We present a challenging case of a previously healthy 23-year-old man who developed an inflammatory myofibroblastic tumour of the hard palate, harbouring a rearrangement of the anaplastic lymphoma kinase (ALK) locus. Despite surgical intervention, radiotherapy and ALK-inhibition therapy, the tumour recurred locally and metastasised to regional lymph nodes, and the patient passed away roughly 9 months after diagnosis from local progression. The rapid progression of this patient's disease and its resistance to treatment demonstrate the potentially aggressive clinical course of inflammatory myofibroblastic tumours. ALK-inhibition therapy was unsuccessful in this ALK-positive tumour, highlighting the need for further investigation of markers predictive of disease progression and treatment response.

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Inflammatory pseudotumor in head and neck

Cited by 29 publications

References 14 publications

Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Laryngeal paralysis associated with a muscle pseudotumour in a young dog

Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity

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