Inflammatory pseudotumor associated with Mycobacterium tuberculosis infection

Androulaki, Athina; Papathomas, Thomas; Liapis, George; Papaconstantinou, Ioannis; Gazouli, Maria; Goutas, Nikos; Bramis, Konstantinos; Papalambros, Alexandros; Lazaris, Andreas C.; Papalambros, Efstathios

doi:10.1016/j.ijid.2007.12.011

Cited by 32 publications

(25 citation statements)

References 15 publications

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“…Table 2 summarizes the main aspects in the differential diagnoses of IPTlike FDCT. In this context IPT may be also included, as it represents a lesion composed of ovoid to spindle cells admixed with polymorphic inflammatory cells, mostly T lymphocytes, but also B cells, plasma cells and histiocytes [16][17][18]. The nature of spindle cells in these lesions is still challenging because of their phenotypic variability.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell proliferation. This tumor occurs primarily in lymph nodes, especially cervical and axillary, however, involvement of extranodal sites such as the tonsils, spleen, liver, and gastrointestinal tract has been reported. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is a rare, distinctive histological subtype of this low-grade malignant neoplasm, with consistent Epstein-Barr virus (EBV) association. The differential diagnosis with other fibro-inflammatory tumor proliferations, as inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT), may be challenging. In the present article, two cases of IPT-like FDCT of the spleen are presented, with a broad overview of the literature: one 77-year-old male and one 70-year-old female. A large immunohistochemical panel should be used for diagnosis, as no single specific and totally sensitive markers are available, including markers for CD21, CD23, CD35, CNA42, and clusterin. Individual cases may express one or more of these markers, so that all of them should be investigated. In situ hybridization for EBV is constantly positive. Immunostaining for ALK should be negative, as it is present in roughly half of the cases of IMT. This panel should be used in combination of clinical, laboratory, and topographic evidences. Importantly, inclusion of this lesion as a possible option in clinical and pathological investigation represents the basis for a correct diagnosis.

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Section: Differential Diagnosesmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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“…These lesions are characterized by a clinical mass which is mostly identified either grossly or as an enhancing lesion on computed tomography (CT) scan. More than often, these masses pose features suggestive of malignancy, including ulceration and infiltration of adjacent structures [1][2][3]. Histologically, they reveal a dense chronic inflammatory infiltrate in a fibrous background and an abundance of plasma cells and/or histiocytes.…”

Section: Introductionmentioning

confidence: 99%

“…While the pathogenesis is not entirely known, many features of IPT can be related to production of inflammatory cytokines that sometimes can occur following surgery or even minor trauma [4][5][6][7][8]. Their occurrence is well-documented in the presence of another malignancy or secondary to multiple infectious agents [1,5,7,9]. We present a rare case of Mycobacterium avium complex (MAC) associated inflammatory pseudotumor of the nasal cavity in a patient with a history of intranasal cocaine abuse.…”

Section: Introductionmentioning

confidence: 99%

Myocbacterium-Avium Intracellulare Associated Inflammatory Pseudotumor of the Anterior Nasal Cavity

Ilyas

Youssef

Chaudhary

et al. 2011

Head and Neck Pathol

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In this case report, we describe an unusual case of mycobacterial associated inflammatory pseudotumor that occurred in a patient with a previous history of cocaine abuse. We discuss inflammatory pseudotumor (IPT) in general and emphasize the rare entity where an associated mycobacterial infection is seen. The histogenesis is not yet completely understood. The lesion can pose challenges for practicing pathologists and a misdiagnosis of malignancy can occur at multiple facets. A discussion about the differential diagnosis and clues to make the distinction is presented. In addition to spindle cell proliferation, the presence of a background of mixed inflammatory cell infiltrate and foamy macrophages are clues to make the diagnosis. In the case of mycobacteria associated IPT, Acid Fast Bacilli (AFB) stains will easily highlight the organisms confirming the diagnosis.

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“…Various factors have been considered as potential originators of IMT, including infection, trauma and autoimmunity (5). Infection has been considered as a significant factor in the initiation of IMT, and several bacteria and viruses have been associated with the development of IMT, including Epstein-Barr virus, human herpes virus, Bacillus sphaericus and Mycobacterium tuberculosis (6). Recently, Li et al (7) described the case of a patient with IMT of kidney, who presented a long-term history of hepatitis B.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

Zhao

et al. 2015

Oncology Letters

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Abstract. Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 43-year-old man who was admitted to the Department of Urology of The Second Xiangya Hospital of Central South University (Changsha, China) in July 2012, with complaints of iterative gross hematuria and abdominal pain unresponsive to antibiotics is described. Computed tomography and magnetic resonance imaging indicated a slightly enhanced mass in the left renal pelvis of 1.5 cm in diameter. On request of the patient, a left nephrectomy was then performed, based on a suspected diagnosis of renal pelvic carcinoma. However, analysis of the intraoperative fast-frozen section exhibited proliferation of compact spindle cells, suggesting IMT. Therefore, further ureterectomy was avoided, and the patient remained in healthy condition thereafter.

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Inflammatory pseudotumor associated with Mycobacterium tuberculosis infection

Cited by 32 publications

References 15 publications

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Myocbacterium-Avium Intracellulare Associated Inflammatory Pseudotumor of the Anterior Nasal Cavity

Inflammatory myofibroblastic tumor of renal pelvis presenting with iterative hematuria and abdominal pain: A case report

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