Inflammatory Proteases in Chronic Otitis Externa

Antonelli, Patrick J.; Schultz, Gregory S.; Cantwell, John S.; Sundin, David J.; Pemberton, Philip A.; Barr, Philip J.

doi:10.1097/01.mlg.0000161339.92633.8d

Cited by 8 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those proteases are involved in chronic inflammatory skin conditions such as psoriasis and atopic dermatitis as well as in inflammatory bowel diseases like Crohn's disease and ulcerative colitis (Wiedow et al, 1992;Baugh et al, 1999;Gao et al, 2005). In addition, a recent study showed elevated levels of these proteases in chronic otitis externa that could be reduced by administration of protease inhibitors (Antonelli et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition?

Benedek

Kopp

Melzig

2007

Journal of Ethnopharmacology

130

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition?

Benedek

Kopp

Melzig

2007

Journal of Ethnopharmacology

130

View full text Add to dashboard Cite

“…Finally, regarding otitis externa, we found cases of external otitis with psoriatic features have been described in 18% of patients with psoriasis, making its diagnosis complex [50]. Additionally, the frequent involvement of the ears in patients with psoriasis could imply an alteration of the epidermal barrier, which could favor superinfection by S. aureus [51]. We did find an association between middle ear infections and psoriasis based on mechanisms similar to those in cystic fibrosis.…”

Section: Comorbidity Of Psoriasismentioning

confidence: 59%

Multimorbidity of Psoriasis: A Large-Scale Population Study of Its Associated Comorbidities

Almenara-Blasco,

Gracia-Cazaña,

Poblador-Plou

et al. 2024

JCM

View full text Add to dashboard Cite

Introduction: Psoriasis is a chronic disease of the skin with a prevalence of 2% in the general population. The high prevalence of psoriasis has prompted the study of its comorbidities in recent decades. We designed a study to determine the prevalence of psoriasis in a large-scale, population-based cohort, to exhaustively describe its comorbidities, and to analyze which diseases are associated with psoriasis. Methods: Retrospective, observational study based on the clinical information contained in the electronic health records of the individuals in the EpiChron Cohort with a diagnosis of psoriasis (31,178 individuals) in 2019. We used logistic regression models and calculated the likelihood of the occurrence of each comorbidity based on the presence of psoriasis (p-value < 0.05). Results: The prevalence of psoriasis was 2.84%, and it was more prevalent in men (3.31% vs. 2.43%). The most frequent chronic comorbidities were disorders of lipid metabolism (35.87%), hypertension (35.50%), and other nutritional-endocrine-metabolic disorders (21.79%). The conditions most associated with psoriasis were (odds ratio; 95% confidence interval) tuberculosis (2.36; 1.24–4.49), cystic fibrosis (2.15; 1.25–3.69), amongst others. We did not find a significant association between psoriasis and hypertension or neoplasms (0.90; 0.86–0.95). Conclusions: This study revealed significant associations between psoriasis and cardiac, psychological, and musculoskeletal comorbidities.

show abstract

The External Ear

Kennedy

2004

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Inflammatory Proteases in Chronic Otitis Externa

Abstract: Elevated levels of proteases found in COE, MMP, and HNE may be inhibited with ilomastat and rAAT. The therapeutic potential of these protease inhibitors warrants investigation.

Cited by 8 publications

References 28 publications

Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition?

Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition?

Multimorbidity of Psoriasis: A Large-Scale Population Study of Its Associated Comorbidities

The External Ear

Contact Info

Product

Resources

About