Inflammatory profiles in febrile children with moderate and severe malnutrition presenting at-hospital in Uganda are associated with increased mortality

Weckman, Andrea M.; McDonald, Chloë R.; Ngai, Michelle; Richard-Greenblatt, Melissa; Leligdowicz, Aleksandra; Conroy, Andrea L.; Kain, Kevin C.; Namasopo, Sophie; Hawkes, Michael

doi:10.1016/j.ebiom.2023.104721

Cited by 3 publications

(1 citation statement)

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“…[ 28 ] Given that it is easily detected using immunochemical methods, it has proven to be a valuable diagnostic and prognostic marker. [ 29 30 31 ] Currently, there are two hypotheses regarding the origin and function of sTREM-1. One is the splicing variant hypothesis, which is derived from the alternative splicing of TREM-1 during post-translational modification.…”

Section: Molecular Biology Of Trem-1mentioning

confidence: 99%

Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target

Fan,

Xu,

Huo

et al. 2024

Chinese Medical Journal

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Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.

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